Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: The present disclosure includes systems, methods, and apparatuses for dispensing a volume (e.g., a volume of liquid or medication) during intraosseous infusion. In some embodiments, a resilient member is used to bias a portion of an arm towards a contracted position with a force sufficient to depress a plunger of a syringe, and a damper is used to resist movement of the portion of the arm from the extended position toward the contracted position to control a rate at which the resilient member can move the portion of the arm from the extended position toward the retracted position, and thereby limit the rate at which a volume is dispensed from the syringe. In other embodiments, a flow control valve may be used instead of a damper to limit the rate at which a volume is dispensed from the syringe.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A root-of-trust of geolocation is provided for an apparatus that includes a trust anchor module with a cryptographic processor and a secure memory. The apparatus further includes a main processor coupled to the trust anchor module and configured to receive a digital geolocation certificate, the geolocation certificate including information identifying the apparatus, information regarding a physical location of the apparatus, information identifying an authorized entity that has verified the physical location of the apparatus, and a digital signature of the authorized entity. The main processor is further configured to cause the trust anchor module to store the digital geolocation certificate in the secure memory such that the digital geolocation certificate is cryptographically bound to the apparatus. The trust anchor module may also include, or otherwise communicate over a secure channel with, a movement sensor associated with the apparatus.

Abstract: Example apparatus and magnetic resonance imaging (MRI) radio frequency (RF) coils concern controlling current magnitude at different sections in one MRI RF coil. In one embodiment, an MRI RF coil comprises a plurality of loop coils configured to transmit or receive an RF signal. A member of the plurality of loop coils comprises an inductor and at least one capacitor. The MRI RF coil further comprises at least one coaxial transmission line that electrically couple in series a first member of the plurality of loop coils with a second, different member of the plurality of loop coils. The at least one coaxial transmission line has a length that is one-quarter wavelength (?/4) of the RF signal, or an odd integer multiple of ?/4 of the RF signal.

Abstract: A chest freezer includes a plurality of insulated walls forming a compartment that includes an upwardly facing opening. A door is configured to selectively provide access to the compartment through the upwardly facing opening. A breaker strip forms at least a portion of an upper periphery of the compartment. A channel is formed in at least a portion of the breaker strip. The channel is configured to permit attachment of a storage container thereto. A cantilevered storage container for a chest freezer is also provided.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: In an automated machine that forms a vertically positioned and horizontally traversing web of plastic film into bags and fills the bags with material, the apparatus opens the bags by separating the bag upper longitudinal edge portions. First and second opposing slide gates on opposite sides of the bags normal traversing plane are moveable between closed and open positions. Longitudinal channels on each of the slide gates receive and clampingly grip the bag longitudinal edge portions when the gates are moved away from their closed positions. The bag edge portions are thereby gripped and separated from one another when the gates are opened for thereby opening and filling the bags. While opening the gates, additional longitudinal edge portions are pulled into the apparatus and, while closing the gates, the additional edge portions are pulled out therefrom. The longitudinal edge portions freely traverse through the channels when the gates are closed.

Abstract: In an automated machine that forms a vertically positioned and horizontally traversing web of plastic film into bags and fills the bags with material, the apparatus maintains tension in the plastic film web and supports and maintains the web horizontally aligned as it traverses through the machine. The apparatus includes upstream and downstream guide rollers. The upstream roller is mounted on an arm which is rotatably biased about a vertical axis and is thereby moveable. The upstream roller has an outer concave perimeter surface and the downstream roller has an outer convex perimeter surface. A longitudinal edge portion of the web extends horizontally from an upstream location, around the upstream roller, to and around the downstream roller and to a downstream location. The web extends vertically below the longitudinal edge portion. A rotational sensor coupled to the arm provides an output signal representative of the location of the arm.

Abstract: In an automated machine that forms a vertically positioned and horizontally traversing web of plastic film into bags and fills the bags with material, after the bags are filled, a pair of gripping fingers clampingly grip and pull the bag upper longitudinal edge portions into a sealing gap between a pair of heat seal bars whereat the bag walls are heat fused together and the bag is sealed closed. A pair of clamp bars below the heat seal bars clampingly engage the bag walls after they are pulled into the gap and prior to heat sealing. The filled bags are linked along their longitudinal edge portions with perforations therebetween. The bags are severed from one another at a perforation when the gripping fingers pull the bag walls into the gap. The gripping fingers are carried on and are moved longitudinally with a pair of belts located vertically above the gap.

Abstract: Apparatus for vertically supporting and maintaining a web of plastic film horizontally aligned in applications such as machines that form the plastic film into bags and fill them. Separate coplanar consecutively spaced plates are aligned with and extend through a web normal traversing plane. One of the plates has a peak edge extending out of the web normal traversing plane in a first direction, whereas another has a peak edge extending out of the web normal traversing plane in a second opposite direction. The peak edges define an undulating plastic film travel path between a web upstream location and a web downstream location. The web of film is tensioned between the upstream location and the downstream location and travels along the continuous undulating path. The film flexibly bends over the peak edges as a result of the tension and is thereby supported and maintained aligned.

Abstract: In an automated machine that forms a vertically positioned and horizontally traversing web of plastic film into bags, the apparatus opens, fills and closes the bags and provides slack in the bag walls to close the bag. The bag upper longitudinal edge portions are separated at a bag opening and closing assembly for thereby opening and filing a bag with material. While the bag is being filled, the bag is supported on a conveyor. The conveyor is raised vertically toward the opening and closing assembly while the bag is being closed for thereby providing slack in the bag walls. The conveyor horizontally conveys the filled bag under while a gripping and pulling assembly pulls the bag longitudinal portions into a heat sealing assembly whereat the bag walls are fused together and sealed closed. The bag is thereafter conveyed away therefrom and the conveyor is again placed in its lower position.

Abstract: In an automated machine that forms a vertically positioned and horizontally traversing web of plastic film into bags and fills the bags with material, the apparatus forms the bags sealed side edges as well as aligned perforations whereat the bags are severed from one another after they are filled with material. The web includes a pair of parallel proximate plastic film walls. A vertically positioned heat seal bar is moveable onto the web severing the walls along a separation line and forming the fore and aft sealed side edges of the bags. A perforation knife is aligned with and positioned vertically above the heat seal bar, and is simultaneously moveable onto the web walls with the heat seal bar thereby forming a vertical perforation line at a web longitudinal edge portion. The separation line and perforation line in the web are thereby aligned.

Abstract: A filtration assembly filters diesel fuel used by a diesel engine and includes a filter element disposed within a housing. The housing includes an unfiltered fuel inlet and a filtered fuel outlet. The filter element disposed within the housing receives fuel from the fuel inlet. The filter element defines a peripheral wall sealably engaging filter media defining an unfiltered side and a filtered side of the filter element. The unfiltered side is enclosed with an impermeable barrier affixed to the peripheral wall and the filtered side is enclosed with a permeable water diffuser through which filtered fuel passes. A water separator assembly is disposed externally to the filter element receiving filtered fuel from the water diffuser. The water separator assembly includes water separator media preventing water from passing into the separator. The separator assembly interconnects to the filtered fuel outlet providing filtered, dewatered diesel fuel to the diesel engine.

Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: An apparatus for protecting against environmental contamination at a drilling site is disclosed. The apparatus is used to form a perimeter around the drilling site, the interior of which is covered by a geomembrane. The portion of the geomembrane found along the perimeter is placed in the groove of the apparatus's base. A key block is then fit into the groove, thereby holding the geomembrane in place by the tension created between the base and the key block. At those perimeter locations that will be traversed by vehicles and equipment, two ramp pieces replace the key block in holding the geomembrane tight against the base.