Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: The present disclosure relates generally to the field of medical devices and establishing access to body lumens. In particular, the present disclosure relates to medical devices, systems and methods for facilitating access to an opening of a body lumen through an endoscope by at least partially dilating the opening with fluid from a fluid source prior to contacting the body lumen.

Abstract: An example computing device is configured to perform functions including receiving a plurality of spectral data associated with a respective plurality of playback environments corresponding to a respective plurality of playback devices. The functions also include, based on the plurality of spectral data, determining a plurality of representative spectral characteristics. The functions also include receiving particular spectral data associated with a particular playback environment corresponding to a particular playback device and identifying a given one of the representative spectral characteristics that is representative of the particular spectral data. The functions also include, based on the given one of the representative spectral characteristics, identifying calibration data for use by the particular playback device when playing back audio and transmitting, to the particular playback device, the calibration data.

Abstract: An example computing device is configured to perform functions including receiving calibration data corresponding respectively to a plurality of playback devices, where each playback device in the plurality of playback devices is located in a respective playback environment other than a first playback environment. The functions also include receiving playback device characteristic data respectively indicating at least one playback device characteristic for each playback device of the plurality of playback devices. The functions also include, based on at least the calibration data and the playback device characteristic data, determining updated playback device configuration information and transmitting data indicating the updated playback device configuration information to a given playback device located in the first environment.

Abstract: A hybrid wheel for vehicles that includes a unitary lug structure, with a mount face and a dish section of the lug structure extending therefrom. The lug structure is usually a cast aluminum alloy. A wheel structure including a high strength polymer encapsulates a portion of the lug structure dish section. Rim ring(s) are included in the wheel structure and are preferably made of a fiber reinforced high strength polymer.

Abstract: The invention provides an air and fluid cleaning system for propelling a cleaning fluid and air onto a vehicle vision device such as a vehicle camera system. The cleaning system comprises at least one fluid nozzle aimed at the camera; at least one cleaning fluid pump fluidly connected to both a fluid supply conduit and a cleaning fluid source; at least one air nozzle aimed at the vehicle camera; and at least one telescopic air jet fluidly connected to the air nozzle, hydraulically connected to the fluid supply conduit, and operated by the fluid pressure provided by the cleaning fluid pump; such that during a first operation time interval only cleaning fluid is propelled onto the vehicle camera and during a second operation time interval only an air jet burst is propelled onto the vehicle camera. The invention further includes a method for cleaning a vehicle camera exposed to ambient.

Abstract: The invention provides an air and fluid cleaning system for propelling a cleaning fluid and air onto a vehicle vision device such as a vehicle camera system. The cleaning system comprises at least one fluid nozzle aimed at the camera; at least one cleaning fluid pump fluidly connected to both a fluid supply conduit and a cleaning fluid source; at least one air nozzle aimed at the vehicle camera; and at least one telescopic air jet fluidly connected to the air nozzle, hydraulically connected to the fluid supply conduit, and operated by the fluid pressure provided by the cleaning fluid pump; such that during a first operation time interval only cleaning fluid is propelled onto the vehicle camera and during a second operation time interval only an air jet burst is propelled onto the vehicle camera. The invention further includes a method for cleaning a vehicle camera exposed to ambient.

Abstract: A computing device may maintain a database of representative spectral characteristics. The computing device may also receive particular spectral data associated with a particular playback environment corresponding to the particular playback device. Based on the particular spectral data, the computing device may identify one of the representative spectral characteristics from the database that substantially matches the particular spectral data, and then identify, in the database, an audio processing algorithm based on a) the identified representative spectral characteristic and b) at least one characteristic of the particular playback device. The computing device may then transmit, to the particular playback device, data indicating the identified audio processing algorithm.

Abstract: A computing device may transmit playback device configuration information to a given playback device. The computing device may then receive calibration data corresponding to each playback device of a plurality of playback devices, and receive playback device characteristic data indicating at least one playback device characteristic for each playback device of the plurality of playback devices. Based on at least the received calibration data and the received playback device characteristic data, the computing device may determine updated playback device configuration information and transmit data indicating the updated playback device configuration information to the given playback device.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: Disclosed are apparatuses and methods including incorporation of additives into a bulk materials container by coating, impregnating, or otherwise applying the additives to at least a portion of the container and/or the material comprising the container. The container may be intended for containing bulk material used in a batch or continuous process, where the container can be consumed by the process along with the bulk material. The additives incorporated into the container can be substances that may be used by the process. The additives can modify the process. The additives can modify and/or condition the product being formed by the process.

Abstract: Disclosed are apparatuses and methods including incorporation of additives into a bulk materials container by coating, impregnating, or otherwise applying the additives to at least a portion of the container and/or the material comprising the container. The container may be intended for containing bulk material used in a batch or continuous process, where the container can be consumed by the process along with the bulk material. The additives incorporated into the container can be substances that may be used by the process. The additives can modify the process. The additives can modify and/or condition the product being formed by the process.

Abstract: A method or applying a fast curing epoxy traffic marking composition is provided in which curing agents are coated on a carrier such as glass beads or porous silica. These carriers are dropped onto the epoxy coating and promote rapid curing of the top layer of the epoxy coating while the bottom layer is given additional time to adhere to the roadway surface.

Abstract: A method for applying a fast curing epoxy traffic marking composition is provided in which curing agents are coated on a carrier such as glass beads or porous silica. These carriers are dropped onto the epoxy coating and promote rapid curing of the top layer of the epoxy coating while the bottom layer is given additional time to adhere to the roadway surface. This enables the application contractor to open a marked roadway in a quicker manner with less motorist disruption.

Abstract: A brake system for a piece of equipment includes a series of rotors and stators, and a first brake actuator including at least one first piston positioned within a first chamber such that pressurization of the first chamber causes the at least one first piston to operatively engage at least one of rotors or stators such that the rotors and stators are compressed together and thereby create braking torque, and may also include a second brake actuator including at least one spring operatively coupled to at least one second piston positioned within a second chamber such that depressurization of the second chamber causes the at least one second piston to operatively engage at least one of the rotors or stators such that the pluralities of rotors and stators are compressed together and thereby create braking torque.

Abstract: The invention refers to an on-board vision and cleaning system comprising a sensor unit mounted in a vehicle body, a cleaning fluid source, a cleaning fluid pump, a nozzle carrier, at least one cleaning fluid nozzle attached to the nozzle carrier, wherein the nozzle carrier is designed as a swivel arm which upon actuation may be flipped from a tilted back position which is a rest position into an elevated position which is an operating position.

Abstract: A system for dispensing a fast curing epoxy traffic marking composition to a transportation corridor includes a plurality of bins positioned on a transportation corridor marking dispensing apparatus. A first bin contains an epoxy coating which is applied by the dispensing apparatus on a transportation corridor. A second bin contains at least one curing agent which is coated on a carrier such as glass beads or porous silica. These carriers are dropped onto the epoxy coating by the dispensing apparatus and promote rapid curing of the top layer of the epoxy coating while the bottom layer is given additional time to adhere to the roadway surface. This enables the application contractor to open a marked roadway in a quicker manner with less motorist disruption. An optional third bin contains retroreflective beads which are applied to the epoxy coating by the dispenser apparatus to improve visibility of the line marking.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-1 or I-A: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-1 or I-A: wherein the variables are as defined herein.

Abstract: Disclosed are apparatuses and methods including incorporation of additives into a bulk materials container by coating, impregnating, or otherwise applying the additives to at least a portion of the container and/or the material comprising the container. The container may be intended for containing bulk material used in a batch or continuous process, where the container can be consumed by the process along with the bulk material. The additives incorporated into the container can be substances that may be used by the process. The additives can modify the process. The additives can modify and/or condition the product being formed by the process.