Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to prodrugs comprising a linker comprising five- or six-membered cyclic acetals and an adjacent specific cleavage site, and to precursor compounds for the synthesis of said prodrugs. In one aspect the present invention relates to antibody-targeted amatoxin conjugates comprising said linkers, to methods for their synthesis, and to the use of said antibody-targeted amatoxin conjugates. In a further aspect, the invention relates to pharmaceutical compositions comprising said conjugates, and to the use of said conjugates or compositions for therapeutic purposes, in particular for tumor therapy and oncology.

Abstract: Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can be used for cancer therapy. They can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.

Abstract: A method for operating a cooking system includes: providing at least one cooking hob device, at least one kitchen utensil, and at least one evaluation device, the cooking hob device including at least one placement surface on which to place kitchen utensils and at least one generator device having at least two induction devices for heating the kitchen utensil placed on the placement surface, and the kitchen utensil being heatable by at least one induction device; assigning at least one transmitting device to each of the at least two induction devices of the cooking hob device, the kitchen utensil including at least one receiving device, each transmitting device of the at least one transmitting device emitting at least one electromagnetic signal, at least intermittently, which signal is received by the receiving device of the kitchen utensil when the kitchen utensil is heated by the corresponding induction device.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: A method for operating a cooking system, the cooking system including a hob, cookware, and a mobile device, includes: transmitting a process instruction from the mobile device to the hob; receiving the process instruction from the mobile device by the hob; transmitting a confirmation request from the hob to the cookware; in response to a confirmation by a user on the cookware, transmitting a confirmation message from the cookware to the hob; and in response to the hob receiving the confirmation message from the cookware, executing the process instruction of the mobile device by the hob.

Abstract: A radar module for level and/or limit level monitoring in plant automation, comprising a radar signal source that generates and transmit a radar signal, the radar signal source having a surface facing a filling material, a radar signal conductor that receives, conducts and emits the radar signal, the radar signal conductor being mounted on the surface of the radar signal source, and a potting compound that at least partially covers the surface of the radar signal source and at least partially covers the radar signal conductor.

Abstract: A placeable cooktop utensil includes: a handle for handling the placeable utensil; a controller; a transmitter unit for transmitting signals from the placeable utensil to the cooktop; and at least one input unit having at least one input area integrated in the handle for a user of the placeable utensil to input a user command, the transmitter unit and the at least one input unit being connected in signal communication with the controller, and the cooktop being controllable by the user command. The handle has a gripping portion for gripping and manually moving the placeable utensil and at least one input portion. The at least one input area is in the at least one input portion. At least one sensor for detecting the handle being approached and/or contacted by the user, is in the gripping portion.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: A radar module for process automation including process measurement technology and the automation industry is provided, the radar module including: a radar signal source configured to generate and to transmit, and/or to receive, a radar signal; and a dielectric radar signal guide configured to receive the radar signal and then to transmit the radar signal to an antenna, a waveguide, and/or a dielectric lens, the dielectric radar signal guide being arranged at a predetermined distance from the radar signal source, forming an intermediate space, and an end face of the dielectric radar signal guide facing the radar signal source at least partially has a metallic layer.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: An arrangement of a microlithographic imaging device, such as one that operates in the EUV range, includes a holding device for holding an optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base unit and more than three separate holding units. The base unit includes a plurality of support interface units, which are spaced apart from one another in the circumferential direction, for connecting the holding device to a support structure. The holding units are connected to the base unit and distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base unit.

Abstract: A computer-implemented method for predicting a feedstuff and/or feedstuff raw material is described. The method comprises providing a near infrared (NIR) spectrum of a sample of an unknown feedstuff raw material and/or feedstuff. The absorption intensities of wavelengths or wavenumbers in the spectrum are transformed to give a query vector. A set of database vectors of a population of spectra of known feedstuff raw materials and/or feedstuffs is also provided, and an outlier database vector is removed based on different comparison methods. The similarity between the query vector and each of database vectors is analyzed to produce a similarity value, and the feedstuff raw material and/or feedstuff of the database vector with the highest similarity is assigned to the sample.

Abstract: A computer-implemented method for predicting a feedstuff and/or feedstuff raw material is described. The method comprises providing a near infrared (NIR) spectrum of a sample of an unknown feedstuff raw material and/or feedstuff. The absorption intensities of wavelengths or wavenumbers in the spectrum are transformed to give a query vector. A set of database vectors of a population of spectra of known feedstuff raw materials and/or feedstuffs is also provided, and these comprise at least 50 spectra of samples of each feedstuff and/or feedstuff raw material from each of its global growing areas. The similarity between the query vector and each of database vectors is analyzed to produce a score, and the feedstuff raw material and/or feedstuff of the database vector with the highest score is assigned to the sample.

Abstract: An optical arrangement of an imaging device for microlithography, particularly for using light in the extreme UV range, includes an optical element and a holding device for holding the optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base element and more than three separate holding units. The holding units are connected to the base element and arranged in a manner distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base element. Each of the holding units establishes a clamping connection between the optical element and the base element. The clamping connection for each holding unit is separate from the clamping connections of the other holding units.

Abstract: The invention relates to a method for producing a cushion for an orthopedic device, the cushion having at least one fluid-filled volume, wherein the method includes compression molding of a three-dimensional first cushion component made of at least a first material, which is preferably elastic, in a mold that comprises an inner mold and an outer mold, and bonding the first cushion component to at least a second cushion component in such a way that the fluid-filled volume is created.

Abstract: A radar module configured for plant monitoring is provided, including: a microwave chip including a radar signal source configured to generate a radar signal; a coupling element connected to the radar signal source by a signal link; and a resonant cavity into which the coupling element projects, the coupling element being configured to couple the radar signal into the resonant cavity, and the resonant cavity being integrated in the microwave chip.

Abstract: A roller bearing (2) having a sleeve (5), by which a rolling element raceway is formed, and a lid (1) held to the sleeve by a snap-on connection, wherein the lid has securing projections (17), which are directed outward, which protrude beyond the sleeve (5) in the radial direction and are provided for axially fixing the lid in a housing (4) surrounding the sleeve.