Abstract: Systems and methods for determining an operating condition of a chemical production plant including at least one catalytic reactor are provided. Via a communication interface operating data and a catalyst age indicator are received (10). At least one target operating parameter for the operating condition of a scheduled production run or a current production run are determined (14). The at least one target operating parameter for the operating condition may be used for monitoring and/or controlling the chemical production plant.

Abstract: The present application relates to a composition comprising (a) at least one immune checkpoint inhibitor and (b) at least one conjugate, wherein said conjugate is comprising (i) a target binding moiety, (ii) at least one amatoxin, and (iii) optionally at least one linker connecting said target binding moiety with said at least one amatoxin. The present application further relates to said composition for use in treating a patient having a cancer, and to a pharmaceutical formulation comprising said composition and additional excipients, as well as to methods of producing and using said composition.

Abstract: A wastegate assembly for controlling flow of exhaust gas includes a valve element having a valve body and a valve shaft. The wastegate assembly further includes a spindle. The wastegate assembly further includes a washer coupled to the valve shaft and spaced from the spindle for securing the spindle to the valve shaft. A plurality of cup springs is disposed between the spindle and the washer. The plurality of cup springs includes at least a first cup spring and a second cup spring, with the first cup spring supported on the spindle head and the second cup spring orientated substantially identical to the first cup spring and disposed directly on the first cup spring.

Abstract: A passive current sensor includes a pair of electrically conductive busbars, a shunt resistor electrically connecting the busbars, and a support having a first pair of voltage drop measuring contacts. At least one of the voltage drop measuring contacts is attached to each of the busbars and forms a direct electrical contact between the at least one voltage drop measuring contact and the busbar.

Abstract: The invention relates to a valve assembly (10) for a charging device, in particular for a wastegate of an exhaust gas turbocharger, comprising a spindle (100), a lever arm (110) coupled to the spindle (100), and a valve unit (200). The lever arm (110) has a connecting element (112), designed as at least partially spherical, and the valve unit (200) has an accommodation region (212) with at least one first conical accommodation surface (214) in which the connecting element (112) is arranged.

Abstract: The present invention relates to a method of preparing a barn dust extract, said barn dust extract, and a composition comprising said barn dust extract. The barn dust extract is useful in the prevention or treatment of a disease.

Abstract: The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

Abstract: The present invention relates to a computer-implemented method for identifying an incorrectly or non-calibrated infrared spectrometer, comprising the steps of a) recording an infrared spectrum of a sample with a first infrared spectrometer to provide a sample infrared spectrum, b) recording an infrared spectrum of the same sample as in step a) with a second infrared spectrometer to provide a reference infrared spectrum, wherein said second spectrometer is a correctly calibrated infrared spectrometer, or b?) providing a reference spectrum of the same sample as in step a), wherein said reference spectrum was recorded on a second infrared spectrometer, which is a correctly calibrated spectrometer, c) determining a difference between the wavelength of each extreme point in the sample of step a) and the wavelength of each extreme point in the reference spectrum of step b) or b?), and d) indicating the infrared spectrometer of step a) as incorrectly calibrated or non-calibrated, when at least one difference was det

Abstract: A wastegate assembly for controlling flow of exhaust gas includes a valve element having a valve body and a valve shaft. The wastegate assembly further includes a spindle having a head defining an opening and including a flat surface. The wastegate assembly further includes a washer coupled to the valve shaft and spaced from the spindle for securing the spindle to the valve shaft. The washer defines a bottom washer surface facing the flat surface of the spindle head, with the bottom washer surface including a flat region and a beveled region. A biasing member is disposed between the flat surface of the spindle and the flat and beveled regions of the washer. The beveled region extends oblique relative to the flat region for minimizing contact between the washer and the biasing member beyond the flat region.

Abstract: A radar transceiver chip for transmitting a transmission signal and for receiving a received signal is proposed. The radar transceiver chip includes a transmitting branch, a receiving branch, a coupler, by means of which the transmitting branch is coupled to the receiving branch, and exactly one antenna terminal for connecting an external antenna to the radar transceiver chip. The coupler is coupled to the antenna terminal and is configured to output at least a portion of the transmission signal to the antenna terminal and to feed at least a portion of the received signal, received via the antenna terminal, into the receiving branch, the receiving branch comprising a receiving mixer which is configured to generate an intermediate frequency signal on the basis of the received signal.

Abstract: A wastegate assembly for controlling flow of exhaust gas includes a valve element having a valve body and a valve shaft. The wastegate assembly further includes a spindle having a head defining an opening and including a flat surface. The wastegate assembly further includes a washer coupled to the valve shaft and spaced from the spindle for securing the spindle to the valve shaft. The washer defines a bottom washer surface facing the flat surface of the spindle head, with the bottom washer surface including a flat region and a beveled region. A biasing member is disposed between the flat surface of the spindle and the flat and beveled regions of the washer. The beveled region extends oblique relative to the flat region for minimizing contact between the washer and the biasing member beyond the flat region.

Abstract: A waveguide coupling for a fill level radar including a waveguide and a high-frequency chip, which projects at least in part into the waveguide and includes a coupling element for coupling the transmission signal into the waveguide.

Abstract: A roller bearing (2) having a sleeve (5), by which a rolling element raceway is formed, and a lid (1) held to the sleeve by a snap-on connection, wherein the lid has securing projections (17), which are directed outward, which protrude beyond the sleeve (5) in the radial direction and are provided for axially fixing the lid in a housing (4) surrounding the sleeve.

Abstract: The invention relates to a valve assembly (10) for a charging device, in particular for a wastegate of an exhaust gas turbocharger, comprising a spindle (100), a lever arm (110) coupled to the spindle (100), and a valve unit (200). The lever arm (110) has a connecting element (112), designed as at least partially spherical, and the valve unit (200) has an accommodation region (212) with at least one first conical accommodation surface (214) in which the connecting element (112) is arranged.

Abstract: A couch top extension includes a first section and a second section extending from the first section. The first section has a varying shape profile and the second section has a substantially uniform shape profile. A couch top extension includes an extension board comprising one or more identifiers capable of providing a detectable signal indicative of an identification of the extension board.

Abstract: A temperature sensor assembly including a carrier part having a receptacle for a temperature pin, a sensor element for measuring a temperature, and a pushing element pushing the sensor element into the receptacle.

Abstract: The invention relates to a method for displaying a notification for a user in which first image data associated with the notification is displayed on a display unit in a normal display mode. The method also includes displaying second image data associated with the notification on the display unit in a safety display mode as soon as a predetermined fault condition is satisfied in the normal display mode. The predetermined fault condition being satisfied is checked by comparing a current display of the first image data by the display unit in the normal display mode, with respect to a presence of image faults, with a reference display of the first image data by the display unit in the normal display mode. The current display and the reference display are subdivided into regions and/or pixels for the comparison, said regions and/or pixels being associated with classes as background, foreground, image edge and/or irrelevant.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: A placeable cooktop utensil includes: a handle for handling the placeable utensil; a controller; a transmitter unit for transmitting signals from the placeable utensil to the cooktop; and at least one input unit having at least one input area integrated in the handle for a user of the placeable utensil to input a user command, the transmitter unit and the at least one input unit being connected in signal communication with the controller, and the cooktop being controllable by the user command. The handle has a gripping portion for gripping and manually moving the placeable utensil and at least one input portion. The at least one input area is in the at least one input portion. At least one sensor for detecting the handle being approached and/or contacted by the user, is in the gripping portion.