Abstract: Systems and methods described herein can use near field communications to locate a radiating transmitter, such as a pill transmitter swallowed by a patient. In some embodiments, the pill transmitter can include multiple transmitting elements configured to transmit signals in an axis orthogonal with respect to each other. Further, in some embodiment, the pill transmitter can also include multiple transmitting elements in each of the three axes where the three axes may be perpendicular with respect to each other. The magnetic field emitted from the pill transmitter can be measured by the receiving antennas, for example, using principles of mutual inductance.

Abstract: Methods, systems, and techniques for analyzing and managing time series workload data are provided. Example embodiments provide a Data Management and Analysis platform that enables end users to modernize their system configurations to incorporate external services techniques, such as cloud technologies, and to utilize virtualization technologies to host some of their functions in a manner that improves the overall performance of their configurations. This may be particularly useful in an IT environment with many interdependent systems where it is hard to analyze and determine where externally hosted or hybrid (e.g., both remote and local) systems might improve the overall delivery of services and cost to end users.

Abstract: Implementations of firearm regulation systems may include a firearm safety system (FSS) configured to physically couple to a firearm. The FSS may include a locking mechanism configured to prevent the firearm from firing and a sensor configured to detect an environmental parameter. The firearm regulation system may also include a management system communicatively coupled to the FSS and a site safety system (SSS) communicatively coupled to the management system. The SSS may include one or more lockdown mechanisms.

Abstract: The present invention relates to methods for detecting sulfenylation within thiol groups in proteins, metabolites, or materials. Protein sulfenylation (Cys-SOH) describes the reversible post-translational modification of protein thiols by hydrogen peroxide, and plays a central role in oxidative signaling (see, e.g., Paulsen, C. E. & Carroll, K. S. 2013 Chemical Reviews 113, 4633-679). Growth factor stimulation activates NADPH oxidase enzymes, releasing a local burst of hydrogen peroxide, which transiently oxidizes the nuclcophilic cysteine of protein phosphatases and other proximal redox active thiols (see, e.g., Paulsen, C. E. et al., 2012 Nature Chemical Biology 8, 57-64). In addition to masking functional cysteine's, sulfenylation is also a critical intermediate towards irreversible cysteine oxidation.

Abstract: A tube clamp assembly for aligning and clamping a pair of tube ends includes: an elongate bar having a channel shaped to substantially conform to receive outer surfaces of adjacent tube ends when the channel is aligned parallel to a longitudinal axis of the adjacent tube ends, the elongate bar further including a bore oriented perpendicular to the longitudinal axis of the adjacent tube ends; a clamping member having an elongate body oriented parallel to the longitudinal axis of the adjacent tube ends, the clamping member having a bore formed therethrough, the bore substantially aligned with the bore of the elongate bar; at least one cable attached to the clamping member and extending around a distal outer wall of the adjacent tube ends; an elongate threaded bolt extending from a first end through the bore of the clamping member and into the bore of the bar member.

Abstract: This disclosure relates to a flexible circuit for insertion into a pill capsule. The flexible circuit has a first portion having an electrical contact to electrically connect with a battery, a second portion having an electrical contact to electrically connect with the battery, a first arm separating the first portion and second portion, a third portion comprising a first antenna, a second arm separating the first portion and third portion, a fourth portion comprising a second antenna, a third arm separating the first portion and fourth portion, a third arm separating the first portion and fourth portion, and a fifth portion comprising a third antenna. The first portion, second portion, and first arm form a first receptacle to receive a battery. The third portion, fourth portion, and fifth portion form a second receptacle to receive a cube ferrite core.

Abstract: A tunable optical device comprising an optical ring cavity and one or more pairs of electrodes for capacitive actuation of the optical tuning. Applying a potential difference to the electrodes applies a capacitive force to the optical ring cavity which changes the optical resonance frequency. The device can be used as a binary optical switch.

Abstract: Systems and methods described herein use near field communications to locate a radiating transponder, such as a pill swallowed by a patient. The system can be triggered to turn on and transmit a waveform to a set of antennas attached to, coupled with, or near the patient. The magnetic field emitted by the transponder can be measured by the receiving antennas, for example, using principles of mutual inductance. The differential phase and/or time shifts between the antennas can contain sufficient information to find the location of the transponder and optionally its orientation relative to body coordinates. The system can display the location and/or orientation of the transponder. Further, the pill can include a reservoir to deliver a payload at a particular site of the patient's body based at least in part on the determined location.

Abstract: This disclosure relates to a flexible circuit for insertion into a pill capsule. The flexible circuit has a first portion having an electrical contact to electrically connect with a battery, a second portion having an electrical contact to electrically connect with the battery, a first arm separating the first portion and second portion, a third portion comprising a first antenna, a second arm separating the first portion and third portion, a fourth portion comprising a second antenna, a third arm separating the first portion and fourth portion, a third arm separating the first portion and fourth portion, and a fifth portion comprising a third antenna. The first portion, second portion, and first arm form a first receptacle to receive a battery. The third portion, fourth portion, and fifth portion form a second receptacle to receive a cube ferrite core.

Abstract: A tube clamp assembly for aligning and clamping a pair of tube ends includes: an elongate bar having a channel shaped to substantially conform to receive outer surfaces of adjacent tube ends when the channel is aligned parallel to a longitudinal axis of the adjacent tube ends, the elongate bar further including a bore oriented perpendicular to the longitudinal axis of the adjacent tube ends; a clamping member having an elongate body oriented parallel to the longitudinal axis of the adjacent tube ends, the clamping member having a bore formed therethrough, the bore substantially aligned with the bore of the elongate bar; at least one cable attached to the clamping member and extending around a distal outer wall of the adjacent tube ends; an elongate threaded bolt extending from a first end through the bore of the clamping member and into the bore of the bar member.

Abstract: Surface-modified glass and polymer membrane interfaces form high-electrical resistance seals that can be used in microfluidic valves and array devices tailored for electrophysiological measurements. The incorporation of high seal resistance valves into the array device allows only the desired electrophysiological signal to be detected by a patch clamp amplifier, enabling parallel experiments with one patch clamp amplifier, which can greatly improve the cost efficiency. To achieve the desired high seal resistance, surface modification was performed on the glass components to increase the interaction between the glass and the membrane surfaces. The valves exhibit seal resistance of >500G? after modification, which is 100× higher than reported for unmodified valves.

Abstract: Systems and methods described herein use near field communications to locate a radiating transponder, such as a pill swallowed by a patient. The system can be triggered to turn on and transmit a waveform to a set of antennas attached to, coupled with, or near the patient. The magnetic field emitted by the transponder can be measured by the receiving antennas, for example, using principles of mutual inductance. The differential phase and/or time shifts between the antennas can contain sufficient information to find the location of the transponder and optionally its orientation relative to body coordinates. The system can display the location and/or orientation of the transponder. Further, the pill can include a reservoir to deliver a payload at a particular site of the patient's body based at least in part on the determined location.

Abstract: A tunable optical device comprising an optical ring cavity and one or more pairs of electrodes for capacitive actuation of the optical tuning. Applying a potential difference to the electrodes applies a capacitive force to the optical ring cavity which changes the optical resonance frequency. The device can be used as a binary optical switch.

Abstract: Surface-modified silica microparticles that are functionalized with stabilized phospholipid vesicles are described herein. These stabilized vesicles can be functionalized with either transmembrane receptors or membrane associated receptors and used for affinity pull-down assays or other chromatographic separation modalities to provide affinity capture/concentration of low abundance ligands in complex mixtures with minimal sample preparation. Further described are methods and apparatus for forming polymer frits in a fused silica capillary. The capillary containing a monomer solution is placed between one or more heat sources connected to each other via a jig and operatively coupled to a temperature controller. The polymer frits are synthesized via thermal polymerization of the monomer solution using the heat sources, which allows for placement of the polymer frits at a spatially-defined location in the capillary.

Abstract: This disclosure relates to a flexible circuit for insertion into a pill capsule. The flexible circuit has a first portion having an electrical contact to electrically connect with a battery, a second portion having an electrical contact to electrically connect with the battery, a first arm separating the first portion and second portion, a third portion comprising a first antenna, a second arm separating the first portion and third portion, a fourth portion comprising a second antenna, a third arm separating the first portion and fourth portion, a third arm separating the first portion and fourth portion, and a fifth portion comprising a third antenna. The first portion, second portion, and first arm form a first receptacle to receive a battery. The third portion, fourth portion, and fifth portion form a second receptacle to receive a cube ferrite core.

Abstract: A valve body in a passage of a housing connected to a through hole in a sealed machine casing can allow an inspection apparatus into an interior of the casing when open, and prevents fluid flow through the passage when closed. Seals can engage the inspection apparatus to prevent fluid flow through the passage during inspection or inspection apparatus movement. A guide conduit in the casing can include branches and can guide the inspection apparatus to multiple inspection sites. Guide marks can identify the branches to assist with navigation within the casing.

Abstract: A hybrid system includes a hybrid module that is located between an engine and a transmission. The hybrid system includes an energy storage system for storing energy from and supplying energy to the hybrid module. An inverter transfers power between the energy storage system and the hybrid module. The hybrid system also includes a cooling system, a DC-DC converter, and a high voltage tap. The hybrid module is designed to recover energy, such as during braking, as well as power the vehicle. The hybrid module includes an electrical machine (eMachine) along with electrical and mechanical pumps for circulating fluid. A clutch provides the sole operative connection between the engine and the eMachine. The hybrid system further incorporates a power take off (PTO) unit that is configured to be powered by the engine and/or the eMachine.

Abstract: The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method comprises a step of injecting light, having a light wavelength equal to the resonance wavelength, into the resonator, so that the injected light resonates within the resonator and triggers a photo-electrochemical etching process enabled by the surrounding fluid containing ions, said etching process being enhanced by the optical resonance which amplifies light intensity in the photonic resonator, the etching decreasing dimensions of the photonic resonator, hereby lowering and tuning the resonance wavelength of the photonic resonator.

Abstract: The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method comprises a step of injecting light, having a light wavelength equal to the resonance wavelength, into the resonator, so that the injected light resonates within the resonator and triggers a photo-electrochemical etching process enabled by the surrounding fluid containing ions, said etching process being enhanced by the optical resonance which amplifies light intensity in the photonic resonator, the etching decreasing dimensions of the photonic resonator, hereby lowering and tuning the resonance wavelength of the photonic resonator.

Abstract: A binocular vision analyzer apparatus is used for determining a prescription of visual aids for the eyes of an individual. The apparatus includes first and second targets respectively corresponding to the first and second eyes of the individual and at least one illuminator unit for illuminating the targets. An optical system is configured to present respective virtual images of the first and second targets so as to be viewable by the respective first and second eyes. At least one beam splitter disposed in front of the first and second eyes directs the virtual images toward the respective eyes. The apparatus also includes first and second spherical correction devices and first and second cylindrical correction devices that respectively correspond to the first and second eyes.