Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an RNA produces a therapeutic result in a subject in need thereof.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: Techniques are disclosed to add augmented reality to a sub-view of a high resolution central video feed. In various embodiments, a central video feed is received from a first camera on a first recurring basis and time-stamped position information is received from a tracking system on a second recurring basis. The central video feed is calibrated against a spatial region encompassed by the central video feed. The received time-stamped position information and a determined plurality of tiles associated with at least one frame of the central video feed are used to define a first sub-view of the central video feed. The first sub-view and a homography defining placement of augmented reality elements on the at least one frame of the central video feed are provided as output to a device configured to use the first sub-view and the homography display the first sub-view.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: The disclosure relates generally to gene editing systems comprising reverse transcriptases and fusion proteins of reverse transcriptases with nickases or nucleases, methods of making such reverse transcriptases and fusion proteins, and methods of using such reverse transcriptases and fusion proteins for site directed genome editing in cells.

Abstract: The disclosure relates generally to gene editing systems comprising reverse transcriptases and fusion proteins of reverse transcriptases with nickases or nucleases, methods of making such reverse transcriptases and fusion proteins, and methods of using such reverse transcriptases and fusion proteins for site directed genome editing in cells.

Abstract: Compositions and methods for impurity removal are provided. A method comprises obtaining a first solution comprising an amino silane compound and a halide impurity. The method comprises contacting the first solution with an anion exchange resin to obtain a second solution. The second solution comprises less of the halide impurity than the first solution.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.

Abstract: This disclosure relates to a computer-implemented method for processing sensor data points by means of a data processing hardware where a distributions buffer for storing an initial plurality of Gaussian distributions is initialized, each Gaussian distribution of the initial plurality of Gaussian distributions including an initial plurality of sensor data points received sequentially from at least one sensor and having an associated predetermined distribution distance threshold, and where the distributions buffer is sequentially updated for a number n of new sensor data points based on a distribution distance condition, generating an updated plurality of Gaussian distributions including either a new Gaussian distribution, or an updated single Gaussian distribution or an updated merged Gaussian distribution.

Abstract: Disclosed herein is an applicator head and associated system and method for applying a coating to an object. The applicator head includes an elongated body with an external surface and an internal cavity. A coating inlet is formed in an upper portion of the elongated body and fluidically coupled with the internal cavity to enable a coating material to flow into the internal cavity from the coating inlet. A plurality of outlet ports are positioned along a lower portion of the elongated body and fluidically coupled with the internal cavity to enable the coating material to be dispensed from the internal cavity. A plurality of external ribs are disposed along the external surface of the elongated body and extend at a rib height from the external surface, at least one outlet port of the plurality of outlet ports is positioned between adjacent ones of the external ribs.

Abstract: A combined fuel level sending unit and fuel fill limit vent valve configured for use with a fuel tank is disclosed including a sending unit rod having a first end and a second end defining a length and a plurality of sensors disposed along its length mounted to a valve body which includes a first valve port, including a receptacle and a valve seat, and a second valve port, mounted to the valve body, in fluid communication and defining an inner sidewall and an outer sidewall. An ullage float comprising a magnet is also slidably mounted on the sending unit rod between the first end and a sealing ledge on the valve seat so that the ullage float fits within the receptacle and valve seat in the valve body. It comprises a magnet configured to interact with the plurality of sensors to provide an indication of a level of fuel in the fuel tank.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: Provided herein are modified oligonucleotides comprising novel GalNAc-containing moieties. Also provided are formulations comprising the modified oligonucleotides disclosed herein, and methods of treating diseases and disorders using the modified oligonucleotides and formulations thereof disclosed herein.

Abstract: A combined fuel level sending unit and fuel fill limit vent valve configured for use with a fuel tank is disclosed including a sending unit rod having a first end and a second end defining a length and a plurality of sensors disposed along its length mounted to a valve body which includes a first valve port, including a receptacle and a valve seat, and a second valve port, mounted to the valve body, in fluid communication and defining an inner sidewall and an outer sidewall. An ullage float comprising a magnet is also slidably mounted on the sending unit rod between the first end and a sealing ledge on the valve seat so that the ullage float fits within the receptacle and valve seat in the valve body. It comprises a magnet configured to interact with the plurality of sensors to provide an indication of a level of fuel in the fuel tank.

Abstract: An ultrasonic system for determining the location of a driver of a vehicle, includes a hand-held device with at least a first ultrasonic sensor, wherein the first ultrasonic sensor has at least one transmitter, and a motor vehicle having a multiplicity of second ultrasonic sensors, wherein the second ultrasonic sensors each have at least one receiver for receiving signals of the first ultrasonic sensor. A method is disclosed for determining the location of a driver of a vehicle.

Abstract: The system and method of fixedly attaching fixed fasteners within a light assembly that are configured to removably retain a breakaway connector and provide grounding to the system. The fixed fasteners are secured such that they do not move with respect to the surface they are attached to. The fixed fasteners may be made of conductive material. In some cases, the fixed fasteners withstand 400 lbs of pull.

Abstract: The system and method for a break-away connector for data and/or electricity. In some cases, the break-way connector has two halves, where one half is inserted into the second half. The half inserted into a mating half may comprise a pair of external housing O-rings. These O-rings provide a way to adjust the force required to separate the two halves. Each half has a tether anchored to a housing that receives an insert. In some cases, an insert is threadedly engaged within a respective housing. The insert may have a plurality of ribs to provide a barrier between a plurality of contacts. The insert may have a set screw style terminal.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.