Abstract: Techniques are disclosed to add augmented reality to a sub-view of a high resolution central video feed. In various embodiments, a central video feed is received from a first camera on a first recurring basis and time-stamped position information is received from a tracking system on a second recurring basis. The central video feed is calibrated against a spatial region encompassed by the central video feed. The received time-stamped position information and a determined plurality of tiles associated with at least one frame of the central video feed are used to define a first sub-view of the central video feed. The first sub-view and a homography defining placement of augmented reality elements on the at least one frame of the central video feed are provided as output to a device configured to use the first sub-view and the homography display the first sub-view.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: Disclosed are systems, devices and methods for continuous and simultaneous monitoring of multiple analytes within interstitial fluid by an integrated system for a microneedle array sensor platform. In some aspects, the device includes a microneedle array sensor unit, an electronics unit and a housing structure. The electronics unit is in electrical communication with an array of electrode probe structures via an array of surface-mount, spring loaded pins, and the electronics unit includes a power source, a data processing unit, and a wireless transmitter. The housing structure is configured to encase, at least partially, the microneedle array sensor unit and the electronics unit, where the array of microneedles is exposed from a side of the housing structure. The device can be configured as a patch worn on skin of a patient user.

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by force mitigation assemblies disposed in the shoe sole. A force mitigation assembly adapted for an athletic shoe includes a linkage to a wearer interface responsive to movement based on activity of the wearer. An attachment to a sole surface receives ground forces transmitted from frictional contact between the sole surface and a surface against which the sole is disposed, such as for running, turning, etc. A force mitigation assembly absorbs these forces received from the sole surface for directing the received force in a controlled manner. An elastic field in the force mitigation assembly is defined by a resilient material adapted to deform in response to the received force.

Abstract: In an embodiment, a process to predict a probability of a future event occurring in a present competition includes receiving time-stamped position information of one or more participants in the present competition. The time-stamped position information is captured by a telemetry tracking system during the present competition. The process uses the time-stamped position information to determine a first play situation of the present competition. The process determines, based on at least the first play situation and playing data associated with at least a subset of one or both of a first set of one or more participants and a second set of one or more participants, a prediction of the probability of a first future event occurring at the present competition.

Abstract: The present invention relates to a chirally-modified dsRNA agent capable of inhibiting the expression of a target gene. The sense and antisense strands of chirally-modified dsRNA agent independently or in combination comprises one or more site specific-site specific/position specific, chirally-modified internucleotide linkages.

Abstract: There is described a method for determining a play duration estimate of an adaptive bit rate (ABR) media presentation. The method comprises receiving at a network entity a media playlist manifest file of the media presentation, wherein the manifest file is transmitted from a content server to a client and comprises a plurality of entries, each entry linking to a respective different one of a plurality of media segments of the media presentation. The method further comprises determining a data size of the manifest file; and determining a play duration estimate of the media presentation based on the determined data size of the manifest file, a first value that represents a data size of each of the plurality of entries in the manifest file and a second value that represents a play duration of each media segment of the plurality of media segments of the media presentation.

Abstract: A ski binding reduces a likelihood of injury to the anterior cruciate ligament (ACL) and the tibia is accomplished by absorption in the binding to limit loads transmitted through the boot-binding interface. Release based on an injury threshold includes a binding response tower attached to the ski and adapted for selective engagement with the ski, such that the binding response tower permits biased vertical and lateral horizontal displacement, prior to a release threshold. The binding is in communication with the boot heel and is adapted for slideable engagement in response to vertical and lateral forces exerted from the boot heel. The binding response tower adapted to disengage, or release upon reaching at least one a predetermined lateral displacement or a predetermined vertical displacement, such as when the boot heel is forced sufficiently sideways or upwards due to skier movement that would tend to cause an ACL injury.

Abstract: Techniques are disclosed to add augmented reality to a sub-view of a high resolution central video feed. In various embodiments, a central video feed is received from a first camera on a first recurring basis and time-stamped position information is received from a tracking system on a second recurring basis. The central video feed is calibrated against a spatial region encompassed by the central video feed. The received time-stamped position information and a determined plurality of tiles associated with at least one frame of the central video feed are used to define a first sub-view of the central video feed. The first sub-view and a homography defining placement of augmented reality elements on the at least one frame of the central video feed are provided as output to a device configured to use the first sub-view and the homography display the first sub-view.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: In an embodiment, a process to predict a probability of a future event occurring in a present competition includes receiving time-stamped position information of one or more participants in the present competition. The time-stamped position information is captured by a telemetry tracking system during the present competition. The process uses the time-stamped position information to determine a first play situation of the present competition. The process determines, based on at least the first play situation and playing data associated with at least a subset of one or both of a first set of one or more participants and a second set of one or more participants, a prediction of the probability of a first future event occurring at the present competition.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: Techniques are disclosed to add augmented reality to a sub-view of a high resolution central video feed. In various embodiments, a central video feed is received from a first camera on a first recurring basis and time-stamped position information is received from a tracking system on a second recurring basis. The central video feed is calibrated against a spatial region encompassed by the central video feed. The received time-stamped position information and a determined plurality of tiles associated with at least one frame of the central video feed are used to define a first sub-view of the central video feed. The first sub-view and a homography defining placement of augmented reality elements on the at least one frame of the central video feed are provided as output to a device configured to use the first sub-view and the homography display the first sub-view.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat depression, neurocognitive disorders, autism spectrum disorder, and/or attention-deficit/hyperactivity disorder.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: An electromagnetic, EM, device, includes: a substrate having a dielectric layer and a first conductive layer at a first side of the substrate, the substrate having a via that extends at least partially through the substrate from the first side toward an opposing second side of the substrate; at least one dielectric structure having at least one non-gaseous dielectric material that forms a first dielectric portion that extends outward from the first side of the substrate, the first dielectric portion having a first average dielectric constant, the at least one dielectric structure further having a second dielectric portion that is contiguous with the first dielectric portion; wherein the second dielectric portion extends into the via of the substrate, the via having a mechanical interlock surface; and wherein the at least one dielectric structure includes a mechanical interlock between the second dielectric portion and the mechanical interlock surface of the via of the substrate.

Abstract: Techniques are described for managing communications between multiple intercommunicating computing nodes, such as multiple virtual machine nodes hosted on one or more physical computing machines or systems. In some situations, users may specify groups of computing nodes and optionally associated access policies for use in the managing of the communications for those groups, such as by specifying which source nodes are allowed to transmit data to particular destinations nodes. In addition, determinations of whether initiated data transmissions from source nodes to destination nodes are authorized may be dynamically negotiated for and recorded for later use in automatically authorizing future such data transmissions without negotiation. This abstract is provided to comply with rules requiring an abstract, and it is submitted with the intention that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: Ullage float assemblies for fuel tanks are disclosed including a guide member with a retaining element mounted to a valve body which includes a first valve port and a second valve port in fluid communication. Methods of preventing spillage of fuel from a fuel tank during a refueling and a diurnal fuel volumetric expansion event are also disclosed. The assemblies and methods.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2?-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.