Abstract: The present invention relates to a chirally-modified dsRNA agent capable of inhibiting the expression of a target gene. The sense and antisense strands of chirally-modified dsRNA agent independently or in combination comprises one or more site specific-site specific/position specific, chirally-modified internucleotide linkages.

Abstract: The present invention relates to a communication disruption system. In a first audio path, a microphone receives input sound, an amplifier system amplifies the sound, and a sound system transmits a first output sound. In a second audio path, the microphone receives input sound, a delay circuit delays the sound, the amplifier system amplifies the sound, and the sound system transmits a second output sound. A target speaker will hear the first and second output sounds, with the first output sound being a reproduction of their speech heard nearly simultaneously with the original speech, and the second output sound being a reproduction of their speech heard slightly after the original speech. Due to the delayed auditory feedback effect, the target speaker's concentration will be disrupted, making it difficult for them to continue speaking.

Abstract: A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated interaural time differences using the first signal and the second signal, converting each of the number of estimated interaural time differences to a corresponding interaural level difference, using one or more of the corresponding interaural level differences to generate an adjusted first signal, and using the adjusted first signal to generate a number of signals delivered to the subject for enhancing the hearing of the subject.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A wearable electromagnetic, EM, apparatus includes: at least one antenna operable in a millimeter-wave-radar-based, MWRB, application; at least one computer processor disposed in signal communication with the at least one antenna; an attachment system configured and adapted to attach to an actor; the at least one antenna and the at least one computer processor disposed in a supported relationship with the attachment system, such that the attachment system with the supported at least one antenna and the at least one computer processor at least partially forms a wearable apparatus that is wearable by the actor.

Abstract: A protective headgear device, or helmet, protects against head injuries such as concussions and CTE by imposing a network of constant force members (CFMs) between an outer impact shell and an inner fitted capsule engaging the skull/head surface. CFMs exhibit a force absorbing behavior that differs from conventional linear spring behavior that impose a counterforce proportional to the displaced distance. CFMs occupy a compact void between the outer impact shell and the inner fitted capsule by component miniaturization and tethers that redirect forces within the void. An absence of conventional foam and straps increases accommodation for the CFMs and connection tethers/attachments. The CFMs exhibit a substantially constant force that avoids a sharp impactful response associated with head injuries.

Abstract: The invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Abstract: A geo-analytical program is integrated into a customer relationship management (CRM) solution. Via the geo-analytical program, users are able to define layer configuration settings for a layer for plotting on a map-based GUI. Layer configuration settings for a respective layer comprise an indication of a data object type serving as a base object type for the respective layer. A method involves receiving from a user user-defined configuration settings for a first layer, electronically receiving, at a geospatial computer system, geospatial data for a plurality of connected devices; electronically receiving, at the geo-analytical program from the geospatial computer system, real-time geospatial data for the plurality of connected devices; and utilizing, by the geo-analytical program, the user-defined layer configuration settings for the first layer to plot the first layer on the map-based GUI based on the received real-time geospatial data for the plurality of connected devices.

Abstract: The present disclosure relates to a portable table (1) and to an interior trim assembly for a vehicle, the interior trim assembly comprising an interior trim section (60) and a portable table releasably attachable to the interior trim section, wherein in a stowage state the portable table is integrated with the interior trim section, and in a detached state the portable table is detached from the interior trim section for use as a table.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: A system and method are disclosed for collecting and analyzing data in a cognitive fabric. The system can include a network of intelligent nodes, each node being configured for sharing or receiving data as a function of analytic processing to be performed at the node.

Abstract: An impact absorbing footwear device employs opposed planar sole portions engaged by a selective resistance coupling that biases the opposed planar sole portions in a non-linear manner in response to forces exerted by the wearer against the sole portion in frictional contact with a floor surface. The planar sole portions are disposed in a footwear appliance that takes the form of an athletic shoe sole. The selective resistance coupling includes a plurality of resilient deformation members that engage the planar sole portions in an opposed circumferentially aligned manner, selectively deform in response to pressure exerted by the wearer for preventing ACL and other impact related injuries, and recover to an undeformed rest position without breakaway to allow the wearer uninterrupted usage while dampening forces that surpass an injury threshold from the resilient deformation that allows the planar sole portions to temporarily misalign.

Abstract: There is described a method for classifying a dataflow being downloaded to a client over a data network from at least a first server as being a live Adaptive Bit Rate (ABR) stream. The method is implemented by an intermediate network entity between the client and the at least a first server in the data network. The method comprises monitoring a sequence of requests sent from the client and a corresponding sequence of responses sent to the client that pass through intermediate network entity in respect of the dataflow. The monitoring comprises measuring a data size of each response in the sequence of responses and determining, based on the monitoring, that the sequence of responses comprises a pattern of responses that is consistent with that expected of a live ABR stream. The dataflow is the classified in response to said determining, as being a live Adaptive Bit Rate (ABR) stream.

Abstract: A system and method for a light panel assembly which is particularly useful for commercial horticultural applications. An extruded heat sink frame provides for a layered light panel assembly with superior heat dissipation characteristics and low power requirements while providing highly efficient returns and output radiant flux.

Abstract: Certain exemplary embodiments can provide an instrument comprising a signal generator. The signal generator is constructed to generate a temporally distinct profile of LIDAR pulses and a reference signal. The instrument comprises a light source coupled to the signal generator. The light source constructed to receive the temporally distinct profile of LIDAR pulses and output corresponding light pulses with temporal spacing substantially equal to those of temporally distinct profile.