Abstract: A syringe assembly includes a syringe and a tamper evident cap disposed over a Luer connection of the syringe, the tamper evident cap having a main body that defines a proximal end defining an opening, a distal end opposite the proximal end along the axial direction, an outer surface, and an inner surface opposite the outer surface that defines a passage to receive a tip cap and the Luer connection, where the tamper evident cap is spaced from the tip cap. The main body further defines a frangible connection between the proximal and distal ends of the main body. The frangible connection can break under a force applied to the distal end of the tamper evident cap such that the proximal end of the tamper evident cap remains engaged with the syringe when the frangible connection breaks.

Abstract: Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

Abstract: Devices and methods for use with syringes are disclosed. A plunger rod includes an outer housing having proximal and distal ends and a lumen between the ends, as well as an inner body axially slidable within the lumen between a first and second position. The inner body has a retention member extending therefrom. When the inner body is in the first position, the plunger rod has a first length, and, when the inner body is in the second position, the plunger rod has a second length greater than the first length. When the inner body is in the second position, the inner body is configured to be rotated relative to the outer housing until the retention member is received within the outer housing to preclude the inner body from moving in the axial direction.

Abstract: A package includes a tray having a plurality of openings and a plurality of barrel covers. Each of the plurality of barrel covers extend through one of the plurality of openings. A tub can receive the tray. A plurality of tamper evident devices can be attached to the plurality of barrel covers. Each tamper evident device includes a collar, a tamper evident cap, and a frangible connection between the collar and the tamper evident cap. A method of packaging a plurality of syringe bodies includes inserting the plurality of syringe bodies into a plurality of barrel covers positioned in a tray, and inserting the tray into a tub.

Abstract: Disclosed are insertion assemblies of rapidly insertable central catheters (“RICCs”) and methods thereof. For example, a RICC insertion assembly can include a RICC, an introducer needle, an access guidewire, and a coupler assembly coupling the foregoing together. The introducer needle can include a needle hub over both a sheath and a needle shaft. The sheath can seal a needle slot except for that under a sheath opening. A distal end of the access guidewire can be disposed in the introducer needle just proximal of a needle tip. The coupler assembly can include a nose piece and a tail piece coupled together. The tail piece can include an extension arm by which a proximal end of the access guidewire is held. The access guidewire can enforce a loop in the access guidewire over which the RICC is disposed, thereby keeping the RICC insertion assembly in a relatively compact form.

Abstract: Disclosed herein are couplers and assemblies thereof for rapidly insertable central catheters (“RICCs”). For example, an introducer-needle assembly for a RICC can include an introducer needle and a coupler coupled therewith. The introducer needle can include a needle having a longitudinal needle slot extending from a proximal portion of the needle shaft through a distal needle tip. A sheath can be over the needle shaft sealing the needle slot thereunder except for a portion of the needle slot under a sheath opening in a proximal portion of the sheath. A needle hub can include a distally extending needle-hub extension arm over the proximal portions of the needle shaft and sheath. The needle hub can also include a needle-hub portion of a RICC clip configured to hold a portion of the RICC therein. The coupler can include a complementary coupler portion of the RICC clip connected to a coupler housing.

Abstract: Disclosed herein are couplers and assemblies thereof for rapidly insertable central catheters (“RICCs”). For example, a coupler assembly can include an introducer needle and a coupler coupled together. The introducer needle can include a needle hub over both a needle shaft and a sheath over the needle shaft. The needle shaft can include a longitudinal needle slot extending through a distal needle tip. The sheath can seal the needle slot thereunder except for the needle slot under a sheath opening in a proximal portion of the sheath. The needle hub can include a needle-hub clip. The coupler can include a coupler housing and an extension arm connected to the coupler housing. The needle-hub clip can be clipped onto the coupler housing in at least a ready-to-deploy state of the coupler assembly. The extension arm can be configured for attaching a proximal end of an access guidewire thereto.

Abstract: Devices and methods for use with syringes are disclosed. A plunger rod includes an outer housing having proximal and distal ends and a lumen between the ends, as well as an inner body axially slidable within the lumen between a first and second position. The inner body has a retention member extending therefrom. When the inner body is in the first position, the plunger rod has a first length, and, when the inner body is in the second position, the plunger rod has a second length greater than the first length. When the inner body is in the second position, the inner body is configured to be rotated relative to the outer housing until the retention member is received within the outer housing to preclude the inner body from moving in the axial direction.

Abstract: A syringe assembly and methods of producing the syringe assembly are described. The syringe assembly may include a syringe body, a plunger rod, a barrel cover, and a tamper evident device. The syringe body has a chamber configured to receive a material. The plunger rod moves within the chamber to dispense the material. The barrel cover covers the syringe body. The backstop is attached to the barrel cover to prevent a portion of the plunger rod from moving proximally through the backstop. The tamper evident device includes a tamper evident cap covering a distal portion of the syringe body, a collar attached to the barrel cover, and a frangible connection between the tamper evident cap and the collar.

Abstract: The present disclosure describes a syringe assembly including a syringe including a Luer connection and a tip, a plunger, a tip cap, a tamper evident cap disposed over the tip cap, and a film including a frangible connection. The film secures the tamper evident cap to the Luer connection, where the frangible connection can break under a force applied to the tamper evident cap such that the tamper evident cap disengages from the Luer connection when the frangible connection breaks.

Abstract: The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1. The proteins can be modified in an exposed surface motif to incorporate OmpT1 cleavage sites. Also provided are nucleic acids encoding the modified proteins, bacterial cells that express the modified proteins, and cell free synthesis systems containing modified RF1. The disclosure further provides methods for reducing the deleterious activity of a modified protein in a cell free synthesis system by contacting the modified protein with OmpT1. Also provided are methods for reducing RF1 competition at an amber codon in the cell free synthesis system, and methods for expressing a protein in the cell free synthesis system. The modified proteins of the invention can be used to increase the yield of proteins having non-natural amino acids incorporated at an amber codon.

Abstract: A syringe assembly includes a syringe and a tamper evident cap disposed over a Luer connection of the syringe, the tamper evident cap having a main body that defines a proximal end defining an opening, a distal end opposite the proximal end, an outer surface, and an inner surface opposite the outer surface that defines a passage to receive a tip cap and the Luer connection, where the tamper evident cap is spaced from the tip cap. The main body defines a frangible connection between the proximal and distal ends thereof. The frangible connection can break under a force applied to the distal end of the tamper evident cap such that the proximal end of the tamper evident cap remains engaged with the syringe when the frangible connection breaks. An RFID tag is disposed on the syringe and has an integrated circuit and an antenna configured to send/receive signals between an RFID reader.

Abstract: The present disclosure describes a syringe assembly including a syringe including a Luer connection and a tip, a plunger, a tip cap, a tamper evident cap disposed over the tip cap, a film including a frangible connection, and an RFID tag. The film secures the tamper evident cap to the Luer connection, where the frangible connection can break under a force applied to the tamper evident cap such that the tamper evident cap disengages from the Luer connection when the frangible connection breaks. The RFID tag is disposed on the syringe and has an integrated circuit and an antenna configured to send/receive signals between an RFID reader.