Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein is BBI.

Abstract: A vacuum can include a housing having an inlet adapted to receive debris being vacuumed. A mounting bar can be fixedly coupled to the housing. A floor collector assembly can be rotatably disposed about a first axis defined by the mounting bar. The floor collector assembly can include a first debris-passing member coupled to the mounting bar, a second debris-passing member rotatably coupled to the first debris-passing member and a third debris-passing member removably coupled to the second debris-passing member. The first debris-passing member can define an opening. The floor collector assembly can be operable in a plurality of modes. In a first mode, the opening can be substantially perpendicular relative to a vacuumed surface. In a second mode, the second debris-passing member can be rotated relative to the first debris-passing member about a second axis such that the opening is at an acute angle relative to the vacuumed surface.

Abstract: The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the present invention provides methods for competitive differential screening that facilitate the identification of tight binders. In some preferred embodiments, the agents used in the methods of the present invention comprise tight and weak binders. In other embodiments, the present invention provides methods that utilize competitive binders that recognize and bind targets, but with binding that is less strong than that of binders of interest.

Abstract: A vacuum can include a housing having an inlet adapted to receive debris being vacuumed. A mounting bar can be fixedly coupled to the housing. A floor collector assembly can be rotatably disposed about a first axis defined by the mounting bar. The floor collector assembly can include a first debris-passing member coupled to the mounting bar, a second debris-passing member rotatably coupled to the first debris-passing member and a third debris-passing member removably coupled to the second debris-passing member. The first debris-passing member can define an opening. The floor collector assembly can be operable in a plurality of modes. In a first mode, the opening can be substantially perpendicular relative to a vacuumed surface. In a second mode, the second debris-passing member can be rotated relative to the first debris-passing member about a second axis such that the opening is at an acute angle relative to the vacuumed surface.

Abstract: A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound peptide complex; separating the target-bound peptide complex from peptides which do not bind to the target, and identifying the target-bound peptides. In one embodiment the target is skin or hair. In another embodiment the anti-target is hair when the target is skin, and the anti-target is skin when the target is hair.

Abstract: A tool for moving an abrasive media can include a tool body and a drive system housed in the tool body. The drive system can include an output member. A retaining member can be disposed on the tool body. A first platen having a first attachment hub can be selectively coupled with the retaining member in an installed position The first platen can have a first rotatable member that selectively attaches to the output member in a first mode of operation. A second platen having a second attachment hub can selectively couple with the retaining member in an installed position. The second platen can have a second rotatable member that selectively attaches to the output member in a second mode of operation.

Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.

Abstract: A portable paint station that includes a work table and a pair of legs that are positionable in a retracted position and an extended position. In one form, the paint station provides a work surface that may be selectively positioned at two distinct heights. In another form, the paint station provides a work surface with a roller tray recess that may be selectively covered to resist the formation of a skin on paint that is located in the recess. In a further form, the paint station provides a work table with a pair of legs. At least one set of the legs has a handle aperture that may be employed to hand carry the paint station on its side. In yet another form, the paint station includes a roller tray assembly that facilitates the short-term storage of a paint roller that is loaded with paint.

Abstract: A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10?7 to 10?10 M. Additionally claimed are the ligands identified according to the method.

Abstract: The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.

Abstract: The present invention provides peptides and supported peptides that bind to FGF-5.