Abstract: An implant insertion tool includes an outer shaft, an inner shaft received in the outer shaft, and two arms coupled to the outer shaft and the inner shaft. The inner shaft translates within the outer shaft and has angled ramps that slide within complementary angled ramps in the two arms. The arms engage an implant for insertion into a body. When the inner shaft translates along a longitudinal axis, it causes the angled ramps to slide against the complementary angled ramps in the arms such that the two arms move laterally relative to the longitudinal axis of the outer shaft to engage and disengage the implant.

Abstract: Microorganisms are genetically engineered to continuously co-produce amino acids, high-value, specialized proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous high-value, specialized proteins can be improved. This can be improved by varying promoters or nutrient limiting means.

Abstract: An electrosurgical instrument for applying radiofrequency or microwave frequency energy to biological tissue. The instrument includes a tip with a planar body separating two conductive elements on opposite surfaces. It also includes a coaxial feed cable with an inner and outer conductor, separated by a dielectric material, for conveying a working signal. The inner conductor connects to the first conductive element, and the outer to the second, enabling the tip to receive the signal. The first conductive element has a pattern to set its electrical length greater than a reference instrument tip. The reference tip has a planar body of the same shape and dimensions, separating two conductive elements covering opposite surfaces.

Abstract: Two components of an aircraft structure are joined by providing a threaded opening in one of them and supporting an alignment insert in that opening. The alignment insert is used to guide drilling of the second component such that a hole is produced which is aligned with the threaded opening, for instance using an alignment projection which physically guides a drill. The alignment insert may then be removed. A fastener is then inserted through that hole and into the threaded opening, then tightened to form the completed joint.

Abstract: An automated window mechanism having an electric motor attached to a sliding panel of a window configured to open and close the window by moving the sliding panel. The electric motor has a locked state in which the electric motor and sliding panel are stationary. The automated window mechanism also includes a monitor configured to detect an external force applied to the sliding panel while the electric motor is in the locked state. In response to the monitor detecting the external force while the electric motor is in the locked state, the positive lead and the negative lead are grounded, rendering the electric motor an electric brake. A method and system for preventing unwanted movement of an automated window are also disclosed.

Abstract: Embodiments of a combustor assembly for a turbine engine are generally provided. The combustor assembly includes a first separable portion defining a dome assembly, and a second separable portion defining a deflector assembly. The first separable portion and the second separable portion are coupled together at a fitted interface.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: Disclosed are systems and methods that provide a novel framework for automatically and dynamically managing a media (or content) library, and effectuating electronic controls and/or notifications related to events of stored files. The framework can i) receive an electronic instruction corresponding to a deletion action for a stored video clip; ii) analyze a datastore comprising an account of a user that includes a collection of video clips corresponding to captured activity at a location associated with the user; iii) locate the video clip within the datastore in association with the user account; iv) delete the video clip from the user account; and v) modify the datastore by automatically inputting a data structure in place of the video clip at a location within the datastore previously held by the video clip, where the data structure includes interactive information associated with the video clip.

Abstract: Some examples of the disclosure are directed to systems and methods for presenting one or more user interface elements including suggested content based on detection of physical objects in a computer-generated environment. In some examples, the electronic device captures one or more images of a physical environment, including a first object (e.g., a fillable form). In some examples, in accordance with detecting, in the one or more images, a first region (e.g., a first fillable field) of the first object and that one or more first criteria are satisfied, the electronic device displays a first user interface element including first suggested text, wherein the first user interface element is displayed at a first location based on the first region.

Abstract: A method and system for migrating a payment instrument portfolio. A payment network computer receives a payment instrument portfolio conversion request message from an issuer computer to convert a payment instrument portfolio from a prior payment instrument scheme to a new payment instrument portfolio based on a new payment instrument scheme. The request message includes information about existing payment instrument references from the prior payment instrument scheme. The payment network computer creates enrollments based on the information about the existing payment instrument references and sends a portfolio migration event notification message to a payment instrument requestor partner computer associated with a payment network payment instrument requestor identifier subscribed to a new event type for the payment instrument portfolio migration.

Abstract: Some examples of the disclosure are directed to systems and methods for performing one or more actions in response to detecting a product in a physical environment. For example, performing the one or more actions include presenting one or more virtual elements in an environment. For example, performing the one or more actions include storing information associated with the product. In some examples, the one or more actions are performed in accordance with one or more criteria being satisfied. For example, the one or more criteria include a criterion that is satisfied when one or more indications of user interest in the product are detected. In some examples, one or more virtual elements are presented in an environment indicating a location of a product within a region of the physical environment. The methods of the disclosure are optionally performed at an electronic device including a head-mounted display.

Abstract: The factor Xia inhibitor milvexian has therapeutic properties useful in the treatment and/or prevention of thrombotic and thromboembolic disorders.

Abstract: Provided herein are fusion proteins comprising a CD8-binding site (e.g., a silent CD8-binding site) and an IL-12 protein. Also provided are pharmaceutical compositions comprising such fusion proteins, expression vectors and host cells for making such fusion proteins, and methods of using such fusion proteins in treating cancers.

Abstract: A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular tissue, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.

Abstract: A combustor for a gas turbine includes a ceramic matrix composite (CMC) dome including a swirler opening therethrough with a flare interface surface surrounding the swirler opening, a swirler assembly including (a) a secondary swirler having a threaded flare attachment portion, and (b) a flare having (i) a threaded secondary swirler attachment portion, and (ii) a dome interface wall that interfaces with the flare interface surface of the CMC dome, and a swirler-dome attachment member. The flare is connected to the secondary swirler via the threaded flare attachment portion and the threaded secondary swirler attachment portion, and the swirler-dome attachment member applies a force to the CMC dome to engage the dome interface wall and the flare interface surface so as to connect the CMC dome and the swirler assembly.

Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.

Abstract: Devices, systems, and methods are provided for registering image data with robotic data for image-guided robotic catheters and other elongate bodies. Fluid drive systems can be used to provide robotically coordinated motion. Precise control over catheter-supported tools is enhanced by alignment of fluoroscopic and ultrasound image data, particularly for structural heart and other therapies in which the catheter will interact with soft tissues. A marker plate having a planar array of machine-readable 2D barcode markers may facilitate alignment of image and robotic data. Determining an ultrasound-based pose of a component in the ultrasound image field allows that component to effectively a fiducial for alignment.

Abstract: An apparatus includes a display, a memory, and a processor. The memory stores events and available conversion options for a policy. The events include a conversion expiration event occurring on a conversion expiration date. Each conversion option is associated with a new policy type into which the policy is convertible prior to occurrence of the conversion expiration event. The processor presents a first page of a GUI, displaying a timeline of the events. The first page also displays a feature selectable to investigate the available conversion options. In response to receiving information associated with a selection of the feature, the processor presents a second page of the GUI, displaying the conversion options. The processor receives information associated with a selection of a first conversion option, and, in response, displays a graph illustrating the behavior of the policy upon conversion to the new policy type associated with the first conversion option.

Abstract: Embodiments of the present invention provide an electric machine control system for a vehicle, the electric machine control system comprising one or more controllers, wherein the vehicle comprises an electric machine arranged to be selectively coupleable to provide torque to at least one wheel of an axle of the vehicle, the control system comprising input means to receive a speed signal indicative of a speed of the vehicle, processing means arranged to determine a desired coupling state (525) of the electric machine to the at least one wheel of the axle in dependence on the speed signal, wherein the processing means is arranged to determine the desired coupling state as coupled in dependence on the speed signal being indicative of a vehicle speed equal to or below a first low-speed threshold (910) and to determine the desired coupling state as no-request in dependence on the speed signal being indicative of a vehicle speed above a second low-speed threshold (920), wherein the second low-speed threshold repres