Abstract: Systems and methods for proactively identifying and surfacing relevant content on an electronic device with a touch-sensitive display are disclosed herein. In one aspect, a method includes presenting content in a first application. At least a portion of the content is presented without requiring input from a user. The method further includes receiving a request to open a second application. In response to receiving the request, the second application is presented with an input-receiving field. Before receiving any user input at the input-receiving field, a selectable user interface object is displayed with an indication that the portion of the content was viewed in the first application, allowing the user to paste at least the portion of the content into the input-receiving field. In response to detecting a selection of the selectable user interface object, the portion of the content is pasted into the input-receiving field.

Abstract: A search apparatus (1) coupled to a database, the apparatus (1) comprising: a processor configured to execute instructions; a memory storing instructions which, when executed by the processor, cause the processor to: search the database for items containing a search term, wherein items containing the search term are matched items; identify fields corresponding to attributes of the matched items; define a range of values for each field; divide the range of values for each field into a plurality of ranged field buckets; distribute the matched items between the ranged field buckets based on attributes of the matched items that are within the range of values for each ranged field bucket; calculate an effectiveness value for each field based on the number of matched items in each of the ranged field buckets; select one or more top fields, each top field having an effectiveness value that is greater than a predetermined effectiveness value; and provide an effectiveness indicator output which is indicative of the ef

Abstract: Systems and methods for proactively identifying and surfacing relevant content on an electronic device with a touch-sensitive display are disclosed herein. In one aspect, a method includes obtaining information identifying a first physical location viewed by a user in a first application. The method further includes detecting a first input. In response to detecting the first input: a second application is identified that is capable of accepting geographic location information; and an affordance is presented that is distinct from the first application, with a suggestion to open the second application. The suggestion includes information about the first physical location. The method further includes detecting a second input at the affordance. In response to detecting the second input at the affordance, the second application is opened and populated to include information that is based at least in part on the information identifying the first physical location.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Vehicular maintenance is predicted using real time telematics data and historical maintenance data. Different statistical models are used, and an intersecting set of results is generated. Environmental weather may also be used to further refine predictions.

Abstract: Systems and methods are provided for controlling lateral movement of a medical capsule system. A capsule housing is configured to be inserted into an anatomical structure of a patient. The multichannel tether is coupled to a rear of the capsule and includes at least one liquid exhaust channel conveying liquid to the capsule housing. The plurality of liquid exhaust ports are positioned around an outer circumference of the capsule housing and each configured to controllably expel liquid laterally from the capsule housing at varying rates to affect lateral movement of the capsule housing.

Abstract: Provided are methods and systems for determining the clinical significance of a genetic variant. The methods entail determining, for the variant, (a) a function score based on known impact of the variant on a biological function of a cell or protein, (b) a frequency score based on the frequency of the variant in a population, (c) a co-occurrence score based on how the variant co-occurs with a reference variant having known clinical significance relating to a clinical disease or condition, and (d) a family segregation score based on how the variant segregates with a disease or condition in a family; and aggregating, on a computer, the function score, the frequency score, the co-occurrence score, the family segregation score to generate a clinical significance score indicating the clinical significance of the genetic variant.

Abstract: Systems and methods for proactively identifying and surfacing relevant content are disclosed herein. An example method includes: detecting, via the touch-sensitive display, a search activation gesture from a user of the electronic device. The method also includes: in response to detecting only the search activation gesture, displaying a search interface on substantially all of the touch-sensitive display, the search interface including: (i) a search entry portion; and (ii) a predictions portion with one or more user interface objects each associated with a respective locally-installed application. Each respective locally-installed application is selected from among a plurality of locally-installed applications for inclusion in the predictions portion based on an application usage history associated with the user of the electronic device.

Abstract: The present disclosure is directed to systems and methods for tracking application data, the method comprising: having a publisher integrate organic install tracking (OIT) code into its website; enabling a visitor to view or click on a link published on the publisher's website or application that links to an application on an application store or on an application download website; passing, via the OIT code, visitor information to an OIT server, the visitor information including impression information, application detail information, visitor click information and visitor device information; determining, with the OIT server, which portions of the visitor information are to be passed to at least one attribution analytics provider (AAP) as attribution data; passing the attribution data to the application's AAP; allowing a user to visit the application store or application download website to download the application, open the application installer and install the application; matching, with the application's AAP

Abstract: The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Abstract: A method for additively manufacturing a component includes generating, via imaging software, a plurality of slices of a support structure of the component based on component geometry. The method also includes melting or fusing, via the additive manufacturing system, layers of material to a build platform of the component so as to form the support structure according to the plurality of slices. The support structure includes a lattice configuration having of a plurality of support members arranged together to form a plurality of cells. Further, the method includes melting or fusing, via the additive manufacturing system, a component body to the support structure. After the component body solidifies, the method includes removing all of the support structure from the component body to form the component.

Abstract: Adjustable rods for use in a filing system are disclosed. An example adjustment member to be coupled to a rod for use in a filing system includes a hook extending laterally from an end of the adjustment member and a mounting portion including a means for mounting the adjustment member to the rod. The example adjustment member also includes a resilient structure coupled to the hook and the mounting portion. In this example, the resilient structure permits the hook to dynamically move longitudinally and adjust an effective length of the adjustment member by adjusting the length of the resilient structure in response to a lateral displacement imposed on the rod.

Abstract: Systems and methods for proactively identifying and surfacing relevant content on an electronic device with a touch-sensitive display are disclosed herein. In one aspect, a method includes executing, on the device, an application in response to an instruction from a user of the electronic device. While executing the application, the method further includes collecting usage data. The usage data at least includes one or more actions performed by the user within the application. The method also includes: automatically, without human intervention, obtaining at least one trigger condition based on the collected usage data and associating the at least one trigger condition with a particular action of the one or more actions performed by the user within the application. Upon determining that the at least one trigger condition has been satisfied, the method includes providing an indication to the user that the particular action associated with the trigger condition is available.

Abstract: Techniques are disclosed for sharing of data exchange among kernels (each a set of instructions) executing on a system having multiple processing units. In an embodiment, each processing unit includes an on-chip scratchpad memory that can be accessed by the kernels executing on the processing unit. All or a portion of the scratchpad memory can be allocated and configured, for example, such that the scratchpad is accessible to multiple kernels in parallel, to one or more kernels in serial, or a combination of both.

Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

Abstract: A housing for a digital assistant is disclosed. The housing includes; a body holding the digital assistant; attachments for an overhead mounting system. Within the housing there is at least one electrical input; and at least one electrical output; along with a digital current limiter. The digital assistant is capable of receiving and implementing instructions via voice commands or a personal control device. The digital current limiter receives instructions from the digital assistant and in response to those instructions, regulates the current to components in communication with the digital assistant. A method for using the housing and digital assistant to create a smart garage system by regulating access to connected components is also disclosed.

Abstract: An apparatus and method relating to a cooling hole of a component of a turbine engine. The component can include a wall separating the hot gas fluid flow from the cooling fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow and at least one cooling hole comprising at least one inlet at the cooled surface, at least one outlet at the heated surface, with the outlet having a modified outlet shape.

Abstract: Systems and methods of processing business related data arising from multiple revenue sources (e.g., sales, subscriptions, professional services, vendors, etc.). In some embodiments, the inventive system and methods enable a more flexible and efficient approach to identifying revenue source events (mediation), pricing those events (typically as part of a rating process), and subsequently leveraging those “ratable events” in the billing and revenue recognition subsystems according to configurable rules and schedules. Data regarding those charges or other aspects of a ratable event may then be used and processed by multiple sub-systems that are part of operating a business; such sub-systems may include one or more of ERP, CRM, HCM, financial, accounting, taxation, or other business-related system or function.

Abstract: A receptacle device which detects when mail has been delivered to the receptacle using a pressure sensor, IR beam, and/or a magnetic sensor. The receptacle device is connected to a wireless or wired network and is configured to communicate with a smart home system at the delivery point. The receptacle detects mail delivery and communicates this information via a network bridge to the smart home device of the recipient. The network bridge also gathers information from an informed delivery system which includes information regarding and images of mailpieces being delivered for a given day. The network bridge sends images of mailpieces which were delivered and additional mailpiece information to the recipient on the smart home system. For parcel, the network bridge can receive information regarding parcels to be delivered and can provide delivery estimates and visual tracking on a map.