Abstract: The present disclosure relates to the treatment of metabolic disorders, such as metabolic syndrome, obesity, and type 2 diabetes. Adjunct therapies and combination therapies that include a myostatin pathway inhibitor, used in conjunction with a GLP-1 pathway activator are disclosed.

Abstract: Presented are control systems for operating dual-independent drive unit (DIDU) powertrains, methods for making/operating such systems, and electric-drive vehicles with fault management and mitigation for DIDU axles. A method of operating a motor vehicle with a DIDU axle includes monitoring first and second drive units (DU) that are independently operable to drive respective road wheels via respective axle shafts of the DIDU axle. A vehicle controller receives an indication of a fault condition in the first DU from a fault sensing module and responsively determines a fault type for the fault condition. The controller ascertains the vehicle's current speed and determines a respective torque limit for each of the DIDU drive units based on the fault type and current vehicle speed. Torque output of the first DU is concomitantly constrained to a first torque limit while torque output of the second DU is constrained to a second torque limit.

Abstract: Devices, systems and methods for removing minerals from a conductive protonic fluid and creating oxidizers therein. A non-alternating flow of electrons in a conductive protonic fluid selectively precipitates hardness causing heavy minerals from the fluid. The decrease in hardness causing minerals leads to the protonic fluid moving towards a thermodynamic equilibrium that prevents precipitation of the noted hardness causing minerals. By-products from the process, like halogens, help oxidize other minerals and treat bio-life within the source. Systems include a vessel containing the conductive protonic fluid, a conductive protonic fluid flow mechanism, a power supply, a control mechanism, and one or more reaction chambers. The reaction chamber has at least one reaction chamber wall having a conductive surface and a conductive element.

Abstract: A method of assessment of a joint may include receiving image data related to one or more images of the joint; determining a B-score, osteophyte volume, and/or a joint-space width based on the image data; generating a first artificial model of the joint based on the determined score, osteophyte volume, and/or joint-space width; and displaying on an electronic display a graphical user interface (GUI). The GUI may include a display of the first artificial model of the joint.

Abstract: Techniques for generating formatting tags for textual content obtained from a source electronic document are disclosed. A system parses a digital file to obtain information about characters in an electronic document. The system applies tags to text generated based on the textual content of the electronic document by creating segments of textually-consecutive characters and applying corresponding text formatting style tags to the segments. The system further identifies segments of text overlapping bounding boxes in the electronic document. The system generates textual content including a segment of text and a corresponding hyperlink associated with the segment of text. The system further generates textual content by selectively applying line breaks from the source electronic document in the textual content.

Abstract: The present disclosure relates to adjusting and maintaining a position of a cutting surface used to create lines of weakness for rolled products. A perforating apparatus includes a housing rotatably supported by a frame, wherein the housing is adapted to rotate about a first axis. A support member including a first cutting surface is rotatably supported by the housing, wherein the support member is adapted to rotate about a second axis offset from the first axis. A roll including a second cutting surface is positioned adjacent the support member, wherein the roll is adapted to rotate about a third axis. The second cutting surface is adapted to contact the first cutting surface as the roll rotates about the third axis. The perforating apparatus is configured such that the functions of adjusting the position of the first cutting surface and holding the first cutting surface in a fixed position are separate.

Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Systems, methods, apparatuses, and software for computing systems are provided herein. In one example, a system includes processing modules each having a communication interface and a processor, and additional modules each having a communication interface. Communication switch circuitry is coupled to the communication interfaces of the processing modules and the communication interfaces of the additional modules, wherein the communication switch circuitry is configured to establish isolation among ports in the communication switch circuitry for one or more processing modules and one or more additional modules. At least one processor instantiates access to the one or more additional modules for the one or more processing modules over at least the isolation.

Abstract: Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device.

Abstract: A powered orthotic device includes a brace, a finger engagement member, a thumb engagement member, and a hand actuator. The powered orthotic device includes an affixment member affixed to the brace, and a finger carrier assembly with a finger carrier to engage the fingers of the wearer, as well as a locking mechanism configured to be removably attached to the affixment member. The wearer dons the orthotic device, without assistance from another, by placing the set of fingers into the finger carrier and using a free hand of the wearer to affix the locking mechanism to the affixment member.

Abstract: A powered orthotic device includes a brace, a finger engagement member, a thumb engagement member, and a hand actuator. The powered orthotic device includes a locking mechanism affixed to the brace, and a finger carrier assembly with a finger carrier to engage the fingers of the wearer, as well as an affixment member configured to be removably attached to the locking mechanism. The wearer dons the orthotic device, without assistance from another, by placing the set of fingers into the finger carrier and using a free hand of the wearer to affix the affixment member to the locking mechanism.

Abstract: A monitoring device receives an identifier for a caregiver, determines an access level for the monitoring device based upon the identifier of the caregiver, and generates a dynamic interface. The dynamic interface being configured based upon the access level of the caregiver. The monitoring devices accesses historical physiological information based upon the access level and suggests one or more alarm limits based upon the historical physiological information.

Abstract: In an aspect, disclosed herein are physiological devices and systems, and components thereof, used to evaluate cardiac parameters and arrhythmogenic mechanisms. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device.

Abstract: Disclosed herein are microfluidic systems with recirculation of fluid and computer-implemented methods of calculating conditions within the microfluidic systems. The microfluidic systems include a computing device and a microfluidic device having first and second reservoirs, at least one chamber, and a fluid path connecting the first reservoir, the chamber, and the second reservoir. The methods for calculating conditions include receiving a first reservoir fluid volume, a second reservoir fluid volume, a first concentration, and a second concentration. The methods further include receiving a time-dependent imposed pressure difference between the first reservoir and the second reservoir, then determining a hydraulic pressure difference and an effective pressure difference. The effective pressure difference is used to account for reactions occurring within the microfluidic device and to determine the value of the condition within the microfluidic device.

Abstract: Systems, methods, apparatuses, and software for computing systems are provided herein. In one example, a system includes processing modules each having a communication interface and a processor, and additional modules each having a communication interface. Communication switch circuitry is coupled to the communication interfaces of the processing modules and the communication interfaces of the additional modules, wherein the communication switch circuitry is configured to establish isolation among ports in the communication switch circuitry for one or more processing modules and one or more additional modules. At least one processor instantiates access to the one or more additional modules for the one or more processing modules over at least the isolation.

Abstract: Polycrystalline diamond cutting elements having enhanced thermal stability, drill bits incorporating the same, and methods of making the same are disclosed herein. In one embodiment, a cutting element includes a substrate having a metal carbide and a polycrystalline diamond body bonded to the substrate. The polycrystalline diamond body includes a plurality of diamond grains bonded to adjacent diamond grains by diamond-to-diamond bonds and a plurality of interstitial regions positioned between adjacent diamond grains. At least a portion of the plurality of interstitial regions comprise lead or lead alloy, a catalyst material, metal carbide, or combinations thereof. At least a portion of the plurality of interstitial regions comprise lead or lead alloy that coat portions of the adjacent diamond grains such that the lead or lead alloy reduces contact between the diamond and the catalyst.

Abstract: Systems, methods, apparatuses, and software for computing systems are provided herein. In one example, a system includes a plurality of first modules each having a Peripheral Component Interconnect Express (PCIe) interface and a processor, and a plurality of second modules each having a PCIe interface. PCIe switch circuitry is coupled to the PCIe interfaces of the first modules and the PCIe interfaces of the second modules, wherein the PCIe switch circuitry is configured to establish logical isolation in the PCIe switch circuitry between one or more first modules and one or more second modules. At least one processor instantiates access to the one or more second modules for the one or more first modules over at least the logical isolation in the PCIe switch circuitry.

Abstract: A compact, powered, orthotic device for pediatric use enables the user to control relative motion of the upper arm and the forearm about the elbow and grasping motions of the thumb and fingers. The device is powered by a set of battery-driven, backdrivable linear actuators that are positioned remotely from an arm of the subject. Control of motion of the device by the subject occurs by means of electromyographic signals from a sensor array in contact with skin on the arm of the subject. The sensors in the sensor array may be held in place on the forearm, on the upper arm, or at any other convenient location on the arm.

Abstract: Systems and methods for health monitoring and upgrade of a distributed controller are provided. According to one embodiment of the disclosure, a method for health monitoring and upgrade of a distributed controller may commence with receiving, by a lower level controller from a high-level controller, high-level control references. The method may further include generating low-level control references for a hardware asset based at least in part on the high-level control references. The method may include monitoring the network connection and detecting an error in the network connection. In response to the detection of the error in the network connection, a control of the hardware asset may be transferred to the low-level controller. The method may further include determining that the network connection has been restored. In response to the determination that the network connection has been restored, the control of the hardware asset may be transferred to the high-level controller.