Abstract: Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.

Abstract: Hierarchical testing systems and methods for testing communication systems are disclosed. Testing functions which test entities such as equipment or services of a communication system are classified into testing function groups. The testing function groups have an order which is based on an order of operational dependencies in the communication system. Testing functions to be performed for a particular entity to be tested are selected from testing functions for testing the entity itself and testing functions for testing other entities that have an operational dependency with the entity to be tested. Related data structures and user interfaces are also disclosed.

Abstract: Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.

Abstract: A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound peptide complex; separating the target-bound peptide complex from peptides which do not bind to the target, and identifying the target-bound peptides. In one embodiment the target is skin or hair. In another embodiment the anti-target is hair when the target is skin, and the anti-target is skin when the target is hair.

Abstract: Nanoparticles coated with tetrazole and methods for preparing them are provided. The nanoparticles can be coated onto a substrate and used in fabricating devices such as field effect transistors, switches, sensors, solar cells and spring exchange magnets.

Abstract: A tool holder, particularly for holding battery operated scissors, has a base with a mechanism coupled with the base to secure the base to a surface. A holder is coupled with the base. The holder includes a pair of members pivotal with respect to one another between an opened and closed position to receive and release the scissors. A locking mechanism locks the pair of members with respect to one another to lock the scissors between the members.

Abstract: A method and system for managing the distribution of multicast content are provided. The method involves creating a list of multicast group addresses to be made available to user units supported by a group of nodes. The list is distributed to all of the nodes in the group of nodes. Filters are created to limit the multicast content that each user unit can receive. The filters are created by referencing the list of multicast addresses previously created. The filters are distributed to the appropriate nodes and applied on customer ports.

Abstract: A connection device includes a plurality of re-configurable vias that connect a first metal layer to a second metal layer. An actuating element is disposed between the first metal layer and the second metal layer. The actuating element changes the configuration of the plurality of re-configurable vias to change the plurality of re-configurable vias between a conductive state and a non-conductive state.

Abstract: A glue gun assembly has a base and a glue gun for application of an adhesive. The glue gun is removably supported by the base. The glue gun has a heating apparatus that can be heated to heat adhesive which flows out of the glue gun. The glue gun also has a temperature indicator that is movable, between positions, depending on the temperature of the heating apparatus. This indicates the temperature of the heating apparatus to the user. The base includes a support member that positions the glue gun such that an exit end of the glue gun is disposed higher than a receiving end of the glue gun. Accordingly, this reduces dripping of glue from the exit end of the glue gun.

Abstract: A valve assembly (18) including: a housing (41) having a water supply inlet (48), a hot water outlet (49), a cold water outlet (50), a hot water flow passage (64) between said water supply inlet and said hot water outlet and a cold water flow passage (65) between said water supply inlet and said cold water outlet; hot water valve means (51) in said housing adapted to open said hot water flow passage (64) in response to entry of water above a predetermined temperature into said housing through said water supply inlet and to close said hot water flow passage in response to entry of water below said predetermined temperature into said housing through said water supply inlet; first cold water valve means (51) adapted to open said cold water flow passage (65) at a first position in response to entry of water below said predetermined temperature into said housing through said water supply inlet and to close said cold water flow passage at said first position in response to entry of water above said predetermined te

Abstract: A soldering assembly has a base with a support member and at least one workpiece support member to support a workpiece. A soldering iron is removably supported by the base support member. The soldering iron includes a heating element and a heatable tip heated by the heating element. The soldering iron also has a temperature indicator that is movable, between positions, depending on the temperature of the heatable tip. Thus, the soldering iron indicates the temperature of the heatable tip to a user.

Abstract: An improved home automation system that permits the user of the system to remotely control the operation of various devices including garage doors and powered entry gates. The system is packaged in a manner that “walks” the user through the initialization process to thereby reduce or eliminate errors associated with the initialization and set-up of the system. Furthermore, the configuration permits the user to initialize the system without the use of tools, such as screwdrivers. The system is configured with improved functionality that permits the user to readily control individual devices and/or selected groups of devices with a powerful hand-held universal remote transmitter.

Abstract: The invention is directed to peptides. Specifically, the invention is directed to peptides which bind skin and do not bind hair. Alternatively, the invention is drawn to peptides which bind hair and do not bind skin.

Abstract: An improved home automation system that permits the user of the system to remotely control the operation of various devices. The system is packaged in a manner that “walks” the user through the initialization process to thereby reduce or eliminate errors associated with the initialization and set-up of the system. Furthermore, the configuration permits the user to initialize the system without the use of tools, such as screwdrivers. The system is configured with improved functionality that permits the user to readily control individual devices and/or selected groups of devices with a powerful hand-held remote transmitter.

Abstract: The present invention provides methods and compositions for milieu-dependent binding of a targeted agent to a target, for example, for the milieu-dependent binding of a diagnostic or therapeutic molecule to a diseased, injured or infected organ, tissue or cell.

Abstract: A method for the preparation of magnetic nanoparticles coated with a noble metal is described. The method includes providing a first mixture containing a first non-polar organic solvent and uncoated magnetic nanoparticles. The first mixture is mixed with a second mixture containing a second non-polar organic solvent and ions comprising the noble metal to form a third mixture. The third mixture is mixed with an organic ligand or a fourth mixture containing an organic ligand to form a fifth mixture. The fifth mixture is reacted with a sixth mixture containing a reducing agent to form a seventh mixture containing the monodispersed magnetic nanoparticles coated with the noble metal. The monodispersed magnetic coated nanoparticles may be separated from the seventh mixture by adding a polar organic solvent or a mixture of polar organic solvents in which the nanoparticles are insoluble.

Abstract: The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.

Abstract: The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.