Abstract: The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be used for homology modelling of other cytochrome P450 structures such as 2C8, 2C18 and 2C19, and for analysis of the interaction of ligands with P450.

Abstract: A high temperature (on the order of about 90° C. or above) non-aqueous synthetic procedure for the preparation of substantially monodisperse IV-VI semiconductor nanoparticles (quantum dots) is provided. The procedure includes first introducing a first precursor selected from the group consisting of a molecular precursor of a Group IV element and a molecular precursor of a Group VI element into a reaction vessel that comprises at least an organic solvent to form a mixture. Next, the mixture is heated to a temperature of about 90° C. or above and thereafter a second precursor which is different from the first precursor and is selected from the group consisting of a molecular precursor of a Group IV element and a molecular precursor of a Group VI element is added into the heated mixture.

Abstract: A device comprising a doped semiconductor nano-component and a method of forming the device are disclosed. The nano-component is one of a nanotube, nanowire or a nanocrystal film, which may be doped by exposure to an organic amine-containing dopant. Illustrative examples are given for field effect transistors with channels comprising a lead selenide nanowire or nanocrystal film and methods of forming these devices.

Abstract: A method is provided for doping nano-components, including nanotubes, nanocrystals and nanowires, by exposing the nano-components to an organic amine-containing dopant. A method is also provided for forming a field effect transistor comprising a nano-component that has been doped using such a dopant.

Abstract: The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced by the methods of the present invention.

Abstract: Compounds of the formula (I), wherein: —X?Y— is selected from —CR<2>=CR<3>— and —CR<2>?N—; R<1> is selected from H, halo, NRR?, NHC(?O)R, NHC(?O)NRR?, NH2SO2R, and C(?O)NRR?; R<2> and R<3> (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R<4> is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R<5> is selected from R<5?>, halo, NHR<5?>, C(?O)NHR<5?>, OR<5?>, SR<5?>, NHC(?O)R<5?>, NHC(?O)NHR<5?>, NHS(?O)R<5?>, wherein R<5?> is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.

Abstract: An organic semiconductor device is formed on a substrate by solution deposition of an active channel layer interposed between a pair of electrodes. The active channel layer includes pentacene formed by thermal treatment of its precursors and operates as a hole carrier. Within the pentacene film are nanoparticles or nanowires of a second material that operate as electron carriers. The electron carrier materials are selected from a group of soluble semiconducting inorganic nanocrystals and nanowires or solube derivatives of fullerene.

Abstract: The present invention provides peptides and supported peptides that bind to FGF-5.

Abstract: The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities.

Abstract: A water feeder controller for a boiler monitors a low water cutoff sensor in a boiler and uses a feed timer to feed water to the boiler for a predetermined feed period of time. The feed timer brings the water level in the boiler well above the low water cutoff sensor. The feed timer supplies water to the boiler only if the low water cutoff sensor continues to indicate a low water level for a delay period of time measured by a delay timer. A resettable display indicates the quantity of water supplied by the water feeder to the boiler based on a feed counter incremented during water feeding. A manual feed button allows water to be manually fed to the boiler. The quantity of water manually supplied to the boiler is also shown on the display. The feed timer and delay timer are preferably implemented in software in a microcontroller in the water feeder controller. A lockout loop in the software prevents overfeeding of water to the boiler in the event of a failure of the low water cutoff sensor.

Abstract: A portable pressure washer having a pump mechanism that is supported by a plurality of wheels. The pump mechanism has a rearwardly extending inlet connection and a forwardly extending outlet connection.

Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.

Abstract: ?9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The ?9 THC acid is t5en converted to ?9 THC which is further purified and combined with a carrier for pharmaceutical use.

Abstract: A magnetic-field sensor device comprises at least two electrodes; an insulating layer separating the at least two electrodes; at least one layer of chemically-synthesized magnetic nanoparticles disposed at or above a level with the insulating layer, and disposed between the at least two electrodes; and an organic spacer surrounding each of the chemically-synthesized magnetic nanoparticles. A deviation between diameters of different ones of the nanoparticles is less than 15%. Moreover, the chemically-synthesized magnetic nanoparticles range in size between 2 nm and 20 nm in diameter.

Abstract: A power tool electrical connector has a first and second connector connected with one another via an electrical cord. The first connector has a base with a configuration that mates with a battery cavity of a power tool in substantially the same way as the power tool's battery is received in the power tool. An electrical connector on the base electrically mates with the electrical connector in the cavity. The second connector has a base with a configuration that receives the power tool's battery in substantially the same way as the power tool's battery is received in the power tool. Also, the second connector includes an electrical connector to electrically couple with the battery.

Abstract: A portable paint station that includes a work table and a pair of legs that are positionable in a retracted position and an extended position. In one form, the paint station provides a work surface that may be selectively positioned at two distinct heights. In another form, the paint station provides a work surface with a roller tray recess that may be selectively covered to resist the formation of a skin on paint that is located in the recess. In a further form, the paint station provides a work table with a pair of legs. At least one set of the legs has a handle aperture that may be employed to hand carry the paint station on its side. In yet another form, the paint station includes a roller tray assembly that facilitates the short-term storage of a paint roller that is loaded with paint.

Abstract: A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10?7 to 10?10 M. Additionally claimed are the ligands identified according to the method.

Abstract: The invention provides techniques for adaptive load balancing. Techniques are provided for monitoring a server's operating conditions; determining, based on the server's operating conditions, when to send a behavior modification hint to one or more clients that are being served by the server; generating the behavior modification hint based on the server's operating conditions; and sending the behavior modification hint to the one or more clients. A client receives the behavior modification hint and, based on the behavior modification hint, alters a timeout value related to the server or alters its preferred server.

Abstract: A tripod assembly having a base and a head mounted to the base. A plurality of legs are coupled to the base and are moveable between an open position and a closed position. The plurality of legs form a tripod to support the base and head in an upright position when the legs are in the open position. The plurality of legs at least partially enclose the base and the head when in the closed position.