Abstract: An image acquisition and analysis system are disclosed. The system enables high throughput, objective analysis of microbial samples over days or weeks. The system may accommodate upwards of twelve 96- or 384-well plates simultaneously (liquid or solid media). The system may acquire and analyze a large number of samples in a short period of time. For example, over 384 samples per minute or 18,432 samples per hour. The system hardware may include a multi-spectral imager (fluorescence and bright field detection), electro-mechanical assemblies, and an optional high-resolution stage. The system may automate image acquisition, image data processing, simplify data storage, and enable automated analysis tools to significantly reduce the manual labor and time associated with such tasks. The system may allow for quick processing and analysis of data into clear phenotypic classes.

Abstract: This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >1010) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed.

Abstract: Disclosed are systems, methods, and apparatuses for automatically and optically determining structural integrity and catch weight information for a pallet. The apparatus can include: a conveyor belt to route a pallet having cases in a facility once the pallet is ingested into the facility, a turntable to receive the pallet from the conveyor belt and rotate the pallet, at least one imaging device proximate the turntable to capture optical data of the pallet, a partial enclosure to enclose the turntable, the at least one imaging device, and at least a portion of the conveyor belt, and an edge computing device in network communication with the at least one imaging device. The edge computing device can: receive the optical data from the at least one imaging device, process the optical data to determine structural integrity and catch weight information for the pallet, and determine routing or storage information for the pallet.

Abstract: A method of fabricating an integrated circuit includes forming a first opening having a first width and a second opening having a second width in a first dielectric layer over a silicon substrate. The openings expose the silicon substrate and the exposed silicon substrate is oxidized to form first and second LOCOS structures having a first thickness. A polysilicon layer is formed over the silicon substrate, so that the polysilicon layer fills the first and second openings. A blanket etch of the polysilicon layer is performed to remove at least a portion of the polysilicon layer over the second LOCOS structure while leaving the first LOCOS structure protected by the polysilicon layer. The silicon substrate under the second LOCOS structure is further oxidized such that the second LOCOS structure has a second thickness greater than the first thickness.

Abstract: A patient interface for delivering breathable gas to a patient includes a nasal prong assembly including a pair of nasal prongs structured to sealingly communicate with nasal passages of a patient's nose in use and headgear to maintain the nasal prong assembly in a desired position on the patient's face. The headgear includes side straps and rigidizers provided to respective side straps. Each rigidizer includes a first end portion that provides a connector structured to engage a respective end of the nasal prong assembly and an inwardly curved protrusion in the form of a cheek support that curves inwardly of the connector. The cheek support is adapted to follow the contour of the patient's cheek and guide a respective end portion of the side strap into engagement with the patient's cheek to provide a stable cheek support.

Abstract: A genealogy system includes a server with memory and processors storing code that instructs the processors to store genealogy data and user profiles, providing a research platform for users. A remote client device, equipped with an image sensor and display, communicates with the server. The client device displays the genealogy research platform, allowing users to select a genealogy item for an artificial reality experience. Upon user command, the client device presents continually updating artificial reality images of an environment, overlaying a digital representation of the selected genealogy item on the artificial reality experience. This system seamlessly integrates genealogical research with artificial reality technology for an immersive user experience.

Abstract: Systems and methods for augmenting a vertebral body. An introducer device includes a shaft having a flexible distal portion with a pre-set curve in an unconstrained state. An input provided to an actuator to tension a pulling element to move the pre-set curve to a constrained state in which the distal portion and a flexible sheath conforming to the shaft at least partially straighten. The introducer device is removable from the sheath remaining offset from a longitudinal axis. A spacer hub facilitates proximal movement of the sheath relative to an access cannula expose a balloon through a syringe-style input. A hub of the access cannula may be adjustable to selectively adjust an interference surface relative to a datum. At least two radiopaque markers may be disposed on the sheath with relative positions between the markers viewable on lateral and A-P radiography to determine the location and/or curvature of the sheath.

Abstract: A filter unit is disclosed that increases solids loading capacity, decreases specific flowrate during filtration, and improves backwash effectiveness. A flow shaping plate and/or flow diverting member are used to reduce flow entrance effects during reverse, backwash flow through the filter unit.

Abstract: A nasal patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways includes a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure, a frame member attachable to the retaining structure, and a positioning and stabilising structure releasably attachable to the frame member.

Abstract: A system for providing to a patient a user experience for securely submitting a prescription to a pharmacy is provided. The system receives a notification of a prescription prescribed by a prescriber for the patient. The system displays to the patient information on drug options relating to the prescribed drug. The system then receives from the patient a selection of a drug option. The system displays to the patient pharmacy options relating to the selected drug option. Each pharmacy option identifies a pharmacy. The system receives from the patient a selection of a pharmacy option. The system then directs that an indication of the prescription be sent to the pharmacy identified by the selected pharmacy option so that that pharmacy can dispense the prescription.

Abstract: Systems and methods for providing an electronics module including a raceway for mounting submodules and establishing electrical communication with said submodules. The raceway comprises a base structure and a conductive trace formed by a conductive plating process. Connection pads on the raceway are configured to receive connection nodes of the submodules for providing a continuous electrical connection between the raceway and the submodules for electrical communication and power transmission.

Abstract: In some embodiments, a method includes receiving first audio data provided via a first device of a first user during a call session between the first device and a second device of a second user, receiving second audio data provided via the second device during the call session, providing the first audio data and/or the second audio data to a large language model (LLM) to determine an intent of the first user, and transmitting a control message in response to determining the intent of the first user is associated with soliciting sensitive information from the second user.

Abstract: Described herein are glycan compounds and particles comprising glycan compounds. The compounds and particles described herein are useful in methods of treating immune and inflammatory-related diseases.

Abstract: A device may include a first end, a second end, and a coupler configured to extend through an aperture from a first side to a second side of a motor cover. The coupler includes a head portion, a conduit portion extending from the head portion towards the second end, and a first bore axially extending through the coupler. The device may include a brush holder extending through the first bore. The brush holder includes a cylindrical body, a socket at the first end, and a receptacle at the second end. The device may include a first lock nut including a first threaded bore axially extending through the nut. The device may be configured to enable a grounding brush to contact a motor shaft to provide a current discharge path to ground to reduce an erosion of the motor components including the motor shaft and rolling bearing elements.

Abstract: A method and system of enabling interactive learning for connected vehicles. The system includes a vehicle data hub (VDH) component, a system learning and update (SLU) component, and an application delivery network (ADN). The VDH component enables cloud-coordinated data collection by the connected vehicles. The VDH component includes a vehicle based portion having a smart buffer in communications with a vehicle communications system and a VDH cloud based service portion. The SLU component is a cloud based service configured to manage data campaigns and specific triggers for efficient collection of data, processing the data, and deploy updated and/or new applications based on the processed data to connected vehicles. The ADN component is disposed on the vehicle and prioritize data campaign requests with respect to other active vehicle services.

Abstract: A plurality of vertically-stacked multicopters detachably couples to a vertical connector to transport a load that is detachably coupled to the vertical connector. In the event an indication signal of a beam break sensor indicates the vertical connector has broken the beam, the movable gate is configured to close so that the vertical connector is enclosed at least in part by the movable gate. An opening in a frame provides access for the vertical connector to access the beam of the beam break sensor.

Abstract: The Social Aggregating, Fractionally Efficient Transfer Guidance, Conditional Triggered Transaction, Datastructures, Apparatuses, Methods and Systems (“SOCOACT”) transforms smart contract request, crypto currency deposit request, crypto collateral deposit request, crypto currency transfer request, crypto collateral transfer request inputs via SOCOACT components into transaction confirmation outputs. An aggregated crypto 2-party transaction trigger entry that specifies at least one associated aggregated blockchain oracle may be instantiated. A first encrypted token may be obtained from a first associated aggregated blockchain oracle. A second encrypted token may be obtained from a second associated aggregated blockchain oracle.

Abstract: In some examples, a controller receives measurement data from a sensor on a vehicle, determines, based on the measurement data, a condition of usage of the vehicle, and selects a parameter set from among a plurality of parameter sets based on the determined condition of usage of the vehicle, the plurality of parameter sets corresponding to different conditions of usage of the vehicle, where each parameter set of the plurality of parameter sets includes one or more parameters that control adjustment of one or more respective adjustable elements of the vehicle. The controller causes application of the selected parameter set on the vehicle.

Abstract: An electrical switchboard is provided. The electrical switchboard includes a plurality of conductive sheets, a plurality of branch devices, each branch device of the plurality of branch devices electrically coupled to each conductive sheet of the plurality of conductive sheets, and a supply device electrically coupled to each conductive sheet of the plurality of conductive sheets. The supply device is configured to supply electric power to the plurality of branch devices via the plurality of conductive sheets.