Abstract: This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >1010) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed.

Abstract: A multi-layered film for packaging products is provided. The film includes a top layer including post-consumer recycled (PCR) plastic, and a bottom layer including PCR plastic and/or virgin fossil-fuel based plastic, the bottom layer being a vapor insulation layer. The film includes 50% or more of PCR plastic by weight.

Abstract: This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >1010) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed.

Abstract: Described herein are glycan compounds and particles comprising glycan compounds. The compounds and particles described herein are useful in methods of treating immune and inflammatory-related diseases.

Abstract: A device may include a first end, a second end, and a coupler configured to extend through an aperture from a first side to a second side of a motor cover. The coupler includes a head portion, a conduit portion extending from the head portion towards the second end, and a first bore axially extending through the coupler. The device may include a brush holder extending through the first bore. The brush holder includes a cylindrical body, a socket at the first end, and a receptacle at the second end. The device may include a first lock nut including a first threaded bore axially extending through the nut. The device may be configured to enable a grounding brush to contact a motor shaft to provide a current discharge path to ground to reduce an erosion of the motor components including the motor shaft and rolling bearing elements.

Abstract: An electrical switchboard is provided. The electrical switchboard includes a plurality of conductive sheets, a plurality of branch devices, each branch device of the plurality of branch devices electrically coupled to each conductive sheet of the plurality of conductive sheets, and a supply device electrically coupled to each conductive sheet of the plurality of conductive sheets. The supply device is configured to supply electric power to the plurality of branch devices via the plurality of conductive sheets.

Abstract: A portable electronic device for assisting a user in locating a condition of a system within a real-world environment is disclosed. The portable electronic device may include a display, an image capture device, and a processor. The processor may be configured to receive, from the image capture device, image data associated with a representation of the real-world environment and to align a virtual model with the real-world environment. The processor may also be configured to receive information associated with the condition of the system and to determine a location in the virtual model corresponding to the condition of the system. Further, the processor may provide a graphical indicator to be displayed over the representation of the real-world environment. The graphical indicator may be displayed at a location on the display that corresponds to a physical location of the condition of the system in the real-world environment.

Abstract: This invention relates to a method of imaging a downhole region of interest. In particular this invention relates to a method of processing images captured downhole to remove or reduce distortions due to the optical system as a function of the temperature experienced by the optical system in the downhole environment. A method of imaging a downhole region of interest comprises contemporaneously capturing an image of a region of interest and recording a temperature associated with the region of interest; selecting a pre-defined set of distortion data from a plurality of pre-defined sets of distortion data based on the recorded temperature; and applying the selected set of distortion data to the captured image to create an un-distorted image, wherein the pre-defined set of distortion data comprises distortion values associated with a range of field angles at a specified temperature.

Abstract: A device may include a first end, a second end, and a coupler configured to extend through an aperture from a first side to a second side of a motor cover. The coupler includes a head portion, a conduit portion extending from the head portion towards the second end, and a first bore axially extending through the coupler. The device may include a brush holder extending through the first bore. The brush holder includes a cylindrical body, a socket at the first end, and a receptacle at the second end. The device may include a first lock nut including a first threaded bore axially extending through the nut. The device may be configured to enable a grounding brush to contact a motor shaft to provide a current discharge path to ground to reduce an erosion of the motor components including the motor shaft and rolling bearing elements.

Abstract: A method for constructing a three-dimensional representation of an internal surface of a conduit comprises obtaining a plurality of images of the internal surface of the conduit, for example from a camera mounted on an inspection tool, constructing, from the plurality of images, a composite image of the internal surface, providing a shape model of the internal surface, constructing, using the shape model, a three-dimensional mesh of the internal surface, and constructing a three-dimensional representation of the internal surface by assigning a pixel value from the composite image to a corresponding node of the mesh. The three-dimensional representation may be derived from two or more sets of images obtained under different image acquisition conditions, such as different camera angles, lighting conditions or spectral sensitivities.

Abstract: Methods for correcting for non-centred tool geometry in image data obtained by a conduit inspection tool are disclosed. Embodiments of the invention apply to inspection tools with one or multiple sideview cameras and to inspection tools with downview cameras. The methods include obtaining at least two overlapping images of the internal surface of the conduit using the tool, identifying one or more features common to at least a pair of the overlapping images, determining, based on the positions of the or each common feature, the position of the tool with respect to a longitudinal axis of the conduit, determining a correction function based on the position of the tool and applying the correction function to the image data. Methods for determining the dimension of a feature of interest on the internal surface of the conduit are also disclosed.

Abstract: A method for determining a corrected axial displacement parameter of a conduit inspection tool, in particular a downhole inspection tool, during transit of the tool axially along a conduit is disclosed. The tool used in the method has an imaging device and may be attached to a control module with a connecting line. The method comprises obtaining successive axially overlapping images of an internal wall of the conduit, determining, from the images, an observed axial displacement parameter of the tool as a function of transit time, identifying, in the images, a plurality of reference points, determining an estimated axial displacement parameter of the tool over an of transit time between successive reference points, and computing the corrected axial displacement parameter of the tool by applying a correction factor to the observed axial velocity of the tool.

Abstract: There is provided polymeric nanoparticles with non-tumour antigen payloads for use in tagging cells for destruction by a subject's immune system and the use thereof for the treatment of cancer. Suitably there is provided a method of treatment comprising administration of nanoparticle comprising a non-tumour protein payload to a subject with cancer, in particular to a cancer cell.

Abstract: An electrical connector for making electrical contact with at least one lead of an electronic device. The connector includes a mounting flange portion and a connector housing portion. The connector also includes at least one conductor having a pin end and a terminal end, wherein the terminal end includes a lead opening that receives the lead and a fastener hole oriented substantially transverse to the lead opening. A fastening element is used to engage the fastener hole and contacts the lead to form electrical contact between the conductor and the lead. The connector further includes a conductor carrier that extends through the connector housing and mounting flange. The conductor carrier includes a base portion and at least one extended portion that extends from the base portion to form a staggered arrangement. The base and extended portions each include a plurality of channels wherein each channel includes a conductor.

Abstract: This invention relates to a method of imaging a downhole region of interest. In particular this invention relates to a method of processing images captured downhole to remove or reduce distortions due to the optical system as a function of the temperature experienced by the optical system in the downhole environment. A method of imaging a downhole region of interest comprises contemporaneously capturing an image of a region of interest and recording a temperature associated with the region of interest; selecting a pre-defined set of distortion data from a plurality of pre-defined sets of distortion data based on the recorded temperature; and applying the selected set of distortion data to the captured image to create an un-distorted image, wherein the pre-defined set of distortion data comprises distortion values associated with a range of field angles at a specified temperature.

Abstract: A computing device can facilitate disposal of packaging material. The packaging material can have a product packaged therein. The packaging material includes an identification tag that includes an identifier. A remote computing device reads the identifier from the packaging material and sends a communication that includes the identifier to the computing device. The computing device identifies a location associated with the remote computing device. The computing device determines location-based disposal information for the packaging material that is based at least in part on the location associated with the remote computing device. The computing device send an indication of the location-based disposal information for the packaging material to the remote computing device.

Abstract: This disclosure relates to methods of generating antibody libraries, antibody libraries produced using such methods, and variant antibodies. Presently, methods of improving antibody binding (affinity maturation assays) require the screening of vast libraries of antibody variants (often >1010) to identify a small fraction of variants with improved characteristics. The present invention involves taking the nucleotide sequence of the framework and complementarity determining region of a target antibody and identifying motifs which would be recognised by deamination somatic hypermutation enzymes. A small library of variants is then created which incorporate one or more of these mutations. It was found that a relatively high proportion of the variants have an increased affinity. The technique of the present invention was demonstrated on the trastuzumab and Cathepsin S antibodies, and the variants produced are also claimed.

Abstract: The presently disclosed subject matter is directed to a method of making a foam, specifically, the development of isocyanate-free foams using at least one unsaturated polyester. The at least one unsaturated polyester is a reaction product of at least one unsaturated cyclic anhydride, dicyclopentadiene, and at least one polyol. The disclosed formulation further comprises at least one reactive diluent and at least one initiator. The disclosed formulations are cured by a free radical mechanism.

Abstract: An electrical connector for making electrical contact with at least one lead of an electronic device. The connector includes a mounting flange portion and a connector housing portion. The connector also includes at least one conductor having a pin end and a terminal end, wherein the terminal end includes a lead opening that receives the lead and a fastener hole oriented substantially transverse to the lead opening. A fastening element is used to engage the fastener hole and contacts the lead to form electrical contact between the conductor and the lead. The connector further includes a conductor carrier that extends through the connector housing and mounting flange. The conductor carrier includes a base portion and at least one extended portion that extends from the base portion to form a staggered arrangement. The base and extended portions each include a plurality of channels wherein each channel includes a conductor.

Abstract: A system includes a data record (such as an Electronic Medical Record (EMR)) and a user interface for modifying (e.g., storing data in) the data record. The data record includes both free-form text elements and discrete data elements. The user interface includes user interface elements for receiving free-form text data. In response to receiving free-form text data via the free-form text user interface elements, a suggested action is identified, such as a suggested action to take in connection with one of the discrete data elements of the data record. Output is generated representing the suggested action. A user provides input indicating acceptance or rejection of the suggested action. The suggested action may be performed in response to the user input.