Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.

Abstract: A commanded control signal is compared against an adaptive control signal in order to detect a rotor strike by a rotor included in an aircraft, wherein the adaptive control signal is associated with controlling the rotor and the adaptive control signal varies based at least in part on the commanded control signal and state information associated with the rotor. In response to detecting the rotor strike, a control signal to the rotor is adjusted in order to reduce a striking force associated with the rotor.

Abstract: Systems, methods, apparatuses and articles of manufacture for mobile advertisement systems are disclosed. A mobile advertising system in accordance with the present disclosure comprises a device capable of determining a geolocation of the device, at least one sensor, coupled to the device, for determining at least a motion of the device, a display, coupled to the device in which the display faces in a direction; and a camera, coupled to the device, in which the camera captures an scene in the direction, in which the device sends at least one image to the display based at least in part on the geolocation of the device, the determined motion of the device, and the scene in the direction, and the display shows the at least one image in the direction.

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

Abstract: 1. A vertical takeoff and landing vehicle which includes an allocation block that receives a set of desired forces or desired moments and a health metric associated with at least one of: (1) a motor controller or (2) a rotor that operates in a vertical takeoff and landing mode at least some of the time. A command signal is determined per a first manner that attempts to satisfy both the set of desired forces or desired moments and the health metric. If the command signal is unable to be determined in the first manner, a second manner is used that prioritizes flight control associated with one or more of a roll axis or a pitch axis over flight control associated with a yaw axis where the axes are mutually orthogonal. The command signal is output to the motor controller that controls the rotor using the command signal.

Abstract: A supercharger transmission case that includes both small and large impeller shaft bearing bores in a single component to avoid potential misalignment, and to allow the bores to be machined during the same machining setup by the same tool. The supercharger transmission case may be fabricated of low thermal expansion material, such as a hypereutectic metal matrix comprising aluminum and silicon, to further reduce thermal expansion of the transmission case and bearings.

Abstract: Various embodiments of methods and apparatus for detecting a change in an orientation of a portion of a structure. In some embodiments, the apparatus includes a processor, an energy storage unit, a location reporting unit, a wireless communication module and one or more inclination sensors. In some embodiments, each of the one or more inclination sensors is configured to measure inclination by measuring an orientation of the each of the one or more inclination sensors relative to a gravitational acceleration vector.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: In one aspect, a vehicle door is provided that includes a plastic inner reinforcement for closing an opening of a vehicle. The plastic inner reinforcement fits the opening of the vehicle to provide reinforcement for the vehicle door about the periphery of the vehicle door. The vehicle door includes an outer shell, an inner cover panel, a support, a hinge portion configured to connect to a corresponding hinge portion of the opening of the vehicle, and a door latch for engaging a door strike of the opening of the vehicle. The support connects the hinge portion and the door latch to inhibit movement of the door latch relative to the hinge portion.

Abstract: Storage systems and methods to provide high-density data storage. Freestanding storage servers include storage drives, left and right backplanes, a backing plate, host adapters, and cables. The left and right backplanes are secured to the backing plate. The mounting holes of each storage drive attached to the left backplane are bilaterally symmetrical about a median plane to the corresponding mounting holes of each storage drive attached to the right backplane. Each left and right backplane has plug receptacles which are aligned and coupled to cables. The plug receptacles of the left backplane are bilaterally symmetrical about the median plane to corresponding plug receptacles of the right backplane. Host adapters are aligned, and each has plug receptacles, organized into a left and a right connector group, which are coupled to cables. For each host adapter, the left connector group is bilaterally symmetrical about the median plane to the right connector group.

Abstract: A patient interface assembly includes an elastomeric piece configured to receive a flow of pressurized respiratory gas and sealingly engage the patient's face. The elastomeric piece forms a plenum and includes a mouth sealing portion, a nasal sealing portion, and an anterior surface with an air inlet opening configured to be coupled to a connector and/or an air delivery tube. The patient interface assembly also includes a stiffening structure that is attached to the anterior surface of the elastomeric piece. The stiffening structure comprises a central aperture that is sized so that the air inlet opening and a portion of the anterior surface surrounding the air inlet opening remain exposed through the central aperture. The stiffening structure is configured so that the entirety of the stiffening structure is inferior to the patient's nose in use.

Abstract: A patient support includes a height adjustable patient support deck, at least one guard structure mounted for movement relative to the patient support deck, and a latch operable to lock the position of the guard structure in a raised position. The patient support further includes a CPR release operable to lower the head deck section of the patient support deck to place the patient support in an emergency state and further operable to release the latch to allow the guard rail structure to lower or be lowered from the raised position.

Abstract: Embodiments herein describe an atomic sensor that includes a photonic die that outputs optical signals on a top surface. These optical signals can be directed and shaped as needed to satisfy a particular type of atomic sensor. In one embodiment, an atomic source (e.g., rubidium or cesium) is disposed on the photonic chip to emit atoms when heated. A collimator can then direct the emitted atoms along a path that intersects with the optical signals. This intersection can be used to detect motion (e.g., rotation and acceleration) of the atomic sensor.

Abstract: Risk prediction models are trained and deployed to analyze images, such as computed tomography scans, for predicting future risk of lung cancer for one or more subjects. Individual risk prediction models are separately trained on nodule-specific and non-nodule specific features such that each risk prediction model can predict future risk of lung cancer across different time periods (e.g., 1 year, 3 years, or 5 years). Such risk prediction models are useful for developing preventive therapies for lung cancer by enabling clinical trial enrichment.

Abstract: Disclosed herein are methods for determining a subject level risk of metastatic cancer involving the training and/or deployment of models to determine 1) a lymph node level risk of individual lymph node involvement and/or 2) a subject level risk of lymph node involvement. Thus, the methods can identify patients who are high or low risk for having nodal disease and optionally enable the guided intervention of cancer patients, for example, via treatment.

Abstract: Systems for augmenting a vertebral body. A deformable conduit assembly includes a hub defining an opening, and a deformable conduit within which a steering instrument is removably disposed. The deformable conduit may be curved by the steering instrument. An expandable member assembly includes a catheter tube slidably positioned through the opening of the hub and a cannula handle of an access cannula, and an expandable structure. The deformable conduit may be moved proximally relative to the hub and the expandable member assembly to expose the expandable structure within the vertebral body. The hub may define one or more guiding slots though which one or more arms are slidably positioned. An axial controller may be coupled to a proximal end of the deformable conduit. The axial controller is configured to receive an input to expose the expandable structure by moving the deformable conduit relative to the hub and the access cannula.

Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder includes a first chamber, a second chamber, at least one inlet tube structured and configured to allow ambient air to enter the first chamber, at least one flow tube structured and configured to allow air to pass from the first chamber to the second chamber, and a blower structured and configured to produce a flow of air at positive pressure. The blower is positioned in the first chamber and structured and configured to receive air from the second chamber. The blower includes a housing structured and configured to sealingly separate air flow through an interior of the housing from the first chamber. The at least one inlet tube is axially spaced from the at least one flow tube.

Abstract: Systems and methods for augmenting a vertebral body. An introducer device includes a shaft having a flexible distal portion with a pre-set curve in an unconstrained state. An input provided to an actuator to tension a pulling element to move the pre-set curve to a constrained state in which the distal portion and a flexible sheath conforming to the shaft at least partially straighten. The introducer device is removable from the sheath remaining offset from a longitudinal axis. A spacer hub facilitates proximal movement of the sheath relative to an access cannula expose a balloon through a syringe-style input. A hub of the access cannula may be adjustable to selectively adjust an interference surface relative to a datum. At least two radiopaque markers may be disposed on the sheath with relative positions between the markers viewable on lateral and A-P radiography to determine the location and/or curvature of the sheath.

Abstract: A wear pad for a longwall mining shield base lift. The wear pad includes at least one spanner hole for rotating the wear pad with a lever, at least one threaded retaining hole, and a retaining bolt threaded through the retaining hole until it contacts a cylinder rod to which the wear pad is to be attached.