Abstract: Surgical anchors and related systems and methods that utilize sutures or other flexible, elongated members to actively deploy a deformable anchor body in a manner that facilitates better deployment of the anchor in the bone, resulting in better fixation and resistance to pull out.

Abstract: Various implementations include systems and approaches for grouping speakers. In some cases, a method includes, configuring a first set of acoustic properties to be applied to an audio device in response to detecting an identifier for a given location; in response to detecting the identifier, automatically applying the first set of acoustic properties to the audio device for audio playback; and in response to no longer detecting the identifier, automatically applying a second set of acoustic properties to the audio device for audio playback, the second set of acoustic properties being different from the first set of acoustic properties in at least one aspect.

Abstract: Described herein are compounds of Formula I: I and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R7, RF, t1, Y1, and Y2 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing template-based excerpting and rendering of multimedia performances technologies. An embodiment includes at least one computer processor configured to retrieve a first content instance and applying a template that results in transforming the first content instance. The first content instance may include a plurality of structural elements. The first content instance may be transformed by a rendering engine running on the at least one computer processor and/or transmitted to a content-playback device. An embodiment of transforming the first content instance includes trimming the content instance based on requirements provided by social media platforms.

Abstract: Systems and methods for remote and host monitoring communication are disclosed. In some implementations, monitoring systems can comprise a host monitoring device associated with a Host communicatively coupled to one or more remote monitoring devices associated with Remote Monitors. The host monitoring device can send communications based at least in part on analyte measurements of a Host sensor and/or other contextual data giving such measurements context. Different remote monitoring devices can receive different communications based at least in part on the role of the respective Remote Monitors relative to the Host. These roles can be reflected in classifications of Remote Monitors.

Abstract: A dosing unit for use in an automatic dosing system of a water-bearing household appliance, for automatically dosing a dosing amount of a solid detergent, the dosing unit comprising a dosing cartridge for storing a bulk of the solid detergent and a dosing device for separating the dosing amount from the bulk and releasing the separated dosing amount by linearly displacing a sliding element from a separating position to a release position, wherein the dosing device includes a dosing channel, wherein, when the sliding element is in the separating position, the dosing channel is configured for receiving at least the dosing amount from the bulk and intermediately storing the dosing amount in a pre-dosing position, and, when the sliding element is in the release position, the dosing device is configured for releasing the dosing amount intermediately stored in the pre-dosing position.

Abstract: Systems, devices, and methods including a processor having addressable memory, where the processor is configured to: collect, via a set of sensors, biological signals related to patient status; collect, via an environmental monitoring device, environmental data associated with an environment of the patient; store, locally via a secure encrypted local database, the collected biological signals and the collected environmental data; detect an abnormality in the collected biological signals; increase measurement frequency of the biological signals by the set of sensors based on the detected abnormality; detect an error in the collected biological signals; determine whether the detected error in the collected biological signals of the current reading is due to environmental factors; correct the determined error in the collected biological signals; and transmit the error corrected collected biological signals as encrypted data.

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: Described herein is a crystalline form of (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one having a powder X-ray diffraction pattern comprising at least one characteristic peak, in terms of 2? at a copper wavelength, selected from 8.7±0.2, 11.1±0.2, and 13.3±0.2.

Abstract: A computer system includes a physical memory having a first page table and a second page table, and an address translation module. The first page table includes primary page table entries, where each page table entry among the primary page table entries is configured to store a mapping of a virtual memory address to a physical memory address and auxiliary information. The second page table includes secondary page table entries each storing at least one further auxiliary information, where each secondary page table entry corresponds to a primary page table entry in the first page table. The address translation module is configured to, in response to receiving a request from a processor, walk through the first page table to identify a primary page table entry and consecutively identify a location of a corresponding secondary page table entry based on a location of the primary page table entry.

Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

Abstract: The present disclosure provides compounds of formula (I?) and uses thereof for the treatment of cancer. Also provided are pharmaceutical compositions and kits comprising the same compounds. The present compounds may have improved anti-tumor effect and reduced toxicity and may be useful for targeting mitochondria in cancer cells.

Abstract: The present invention relates to methods for separating enantiomers of 5-phenyl and 5-naphthyl substituted 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl)phthalazin-1(2H)-ones using N-Boc-L-phenylalanine, N-Boc-D-phenylalanine, and similar chiral acids.

Abstract: Aspects of the subject disclosure may include, for example, an electrochemical apparatus, comprising a pair of electrodes each composed of an intercalation host compound (IHC), a separator disposed between the pair of electrodes, and a controller configured to control cycling of the electrochemical apparatus, wherein the pair of electrodes is configured to undergo, during the cycling, reduction-oxidation (redox) reactions in electrolyte solutions that facilitate capturing of carbon dioxide (CO2) and release of captured CO2. Additional embodiments are disclosed.

Abstract: A wood-type golf club head includes a depth in a front to rear direction no less than 80 mm, a striking face including a face center located in a virtual vertical center plane aligned with the face center and extending in the front to rear direction, a rear portion opposite the striking face, a heel portion, a toe portion opposite the heel portion, a crown, and a sole opposite the crown. The sole includes a first rail and a second rail projecting from the sole base surface and having a first length and a second length, respectively, in the front to rear direction that are less than 75% of the front to rear depth of the club head and the first rail and the second rail are entirely spaced in a heel to toe direction more than 15 mm from the virtual vertical center plane.

Abstract: A golf club head comprises a sole portion including a sole base surface, a leading edge having a virtual vertical leading edge plane, a trailing edge having a virtual vertical trailing edge plane, and a sole width defined by a distance between the virtual vertical leading edge plane and the virtual vertical trailing edge plane. The sole portion further includes a first sole rail projecting from the sole base surface, the first sole rail having a first length, a second sole rail projecting from the sole base surface and located toe-ward of the first sole rail, the second sole rail having a second length that is less than 60% of the sole width, and a third sole rail projecting from the sole base surface and located heel-ward of the first sole rail, the third sole rail having a third length that is less than 60% of the sole width.

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I: or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.

Abstract: A computer system includes a physical memory having a first page table and a second page table, and an address translation module. The first page table includes primary page table entries, where each page table entry among the primary page table entries is configured to store a mapping of a virtual memory address to a physical memory address and auxiliary information. The second page table includes secondary page table entries each storing at least one further auxiliary information, where each secondary page table entry corresponds to a primary page table entry in the first page table. The address translation module is configured to, in response to receiving a request from a processor, walk through the first page table to identify a primary page table entry and consecutively identify a location of a corresponding secondary page table entry based on a location of the primary page table entry.