Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

Abstract: A solid-state memory may have many non-individually erasable memory cells arranged into calibration groups with each memory cell in each respective calibration group using a common set of read voltages to sense programmed states. An evaluation circuit of the solid-state memory may be configured to measure at least one read parameter for each calibration group responsive to read operations carried out upon the memory cells in the associated calibration group. An adjustment circuit of the solid-state memory may redistribute the memory cells of an existing calibration group into at least one new calibration group in response to the at least one measured read parameter.

Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.

Abstract: A breath-sample contained (100) comprising an inlet (102) for receiving a breath sample, a wall (104) at least partially defining a chamber (106) for containing the breath sample, and a valve (110) between the inlet (102) and the chamber (106). The valve (110) is in fluid communication with the inlet (102) and the chamber (106), and is configurable between at least a first open configuration (110a) for flow of breath sample from the inlet (102) to the chamber (106) up to a first flow rate, and a second open configuration (110b) for flow of breath sample from the inlet (102) to the chamber (106) at a second flow rate greater than the first flow rate. Once the valve (110) has been configured in the second open configuration (110b), the valve (110) cannot then reconfigure itself to the first open configuration (110a).

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: A hydraulic pump to synchronize the operation of a pair of hydraulic actuators wherein each hydraulic actuator comprises a cylinder including a first fluid port and a second fluid port formed in the proximal and distal end portions thereof respectively and having a piston disposed therein coupled to a piston rod at least partially disposed within the corresponding cylinder. The dual hydraulic pump includes a triple gear assembly to alternately feed pressurized hydraulic fluid to the first fluid port of each hydraulic actuator simultaneously or the second fluid port of each hydraulic actuator simultaneously to synchronize the linear movement of each piston and piston rod in a first direction or a second direction.

Abstract: Cooking devices, cooking systems, and smoke assemblies for use therewith are provided. In one embodiment, a cooking system is provided and includes a housing and a smoke assembly. The housing can have a lower base portion and an upper lid portion that together define a hollow cooking chamber. The smoke assembly can be coupled to the upper lid portion, and can be in fluid communication with the hollow cooking chamber. The smoke assembly can generate smoke during cooking operations in order to impart smoke flavor onto a food product disposed within the hollow cooking chamber.

Abstract: Cooking devices, cooking systems, and smoke assemblies for use therewith are provided. In one embodiment, a cooking system is provided and includes a housing and a smoke assembly. The housing can have a lower base portion and an upper lid portion that together define a hollow cooking chamber. The smoke assembly can be coupled to the upper lid portion, and can be in fluid communication with the hollow cooking chamber. The smoke assembly can generate smoke during cooking operations in order to impart smoke flavor onto a food product disposed within the hollow cooking chamber.

Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

Abstract: Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods. Some embodiments include methods for modifying and purifying complex mixtures of molecules by exchange of functional tags.

Abstract: A method for managing software on a device is provided. The method comprises: receiving, from a third party associated with the device, by a software administrator of an organization different from the third party, release information regarding software versions for the device; creating, by the software administrator, a profile that specifies whether or not at least one of the software versions is allowed on the device; and transmitting the profile, by the software administrator to a server computer associated with the third or other parties, to promote enforcement of the profile for the device.

Abstract: A burr hole device is configured to receive a catheter and a cable of a sheath. The sheath is configured to receive a portion of the catheter and has an electrode. When the catheter and sheath are implanted with the burr hole device, the catheter and electrode of the sheath are implanted in a brain. Systems and apparatuses may include the burr hole device and/or a cranial port device, the catheter, and the sheath.

Abstract: Novel compounds and compositions including the same and methods of manufacturing and using the same, particularly for increasing klotho gene expression, and more particularly for increasing circulating or soluble Klotho protein levels through increasing klotho gene expression.

Abstract: Novel compounds and compositions including the same and methods of manufacturing and using the same, particularly for inhibiting HDAC or HDAC activity, and more particularly for enhancing renal recovery following acute kidney injury (AKI), preferably through HDAC inhibition.

Abstract: Systems and methods are disclosed for providing a subscription travel service. The systems and methods include operations for receiving travel information with a travel date for a user; computing a subscription value as a function of a booking date and the travel date; determining a minimum travel value and a maximum purchase amount based on the computed subscription value; receiving a request from the user to reserve a given travel service having a first cost that exceeds the minimum travel value and a second cost that is less than the maximum purchase amount; and identifying a travel end date for the given travel service; and preventing the user from reserving another travel service for a specified period of time of the travel end date.

Abstract: A connector device for connecting at least one electrical conductor to at least one electrically conducting contact face of a circuit board includes a housing, at least one first connection unit and at least one second connection unit. The connector device has a SMD-capable contact geometry. The SMD-capable contact geometry has at least one first circuit board contact and at least one second circuit board contact with one spring arm having a respective contact projection.

Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.

Abstract: A photovoltaic module includes at least two cell assemblies externally contactable at connecting contacts, which are arranged linearly at the rear side of the photovoltaic module in groups of two connecting contacts which are allocated to the cell assemblies. One connection socket is arranged on a rear side of the photovoltaic module, this connection socket having a housing which has at least one rear opening for passing the connecting contact through, wherein the housing covers all connecting contacts of the photovoltaic module. In a connection socket for such a photovoltaic module, the housing has an elongated shape, wherein all connecting contacts are arranged in a line along a longitudinal direction of the housing.

Abstract: The subject matter disclosed herein provides methods for presenting glucose level data. Glucose data for a patient may be received. A current glucose level and a rate of change of the current glucose level may be determined based on the received glucose data. A first interface may be displayed on a screen of a device. The first interface may include a unitary icon. The unitary icon may display the current glucose level and a visualization of the rate of change. Related apparatus, systems, techniques, and articles are also described.

Abstract: A method of distributed authorization of one or more client applications to one or more connected devices. The method comprises: receiving at a connected device, from a browser executing a client application, a client token and an access request.