Abstract: In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

Abstract: The present disclosure provides compounds of formula (I?) and uses thereof for the treatment of cancer. Also provided are pharmaceutical compositions and kits comprising the same compounds. The present compounds may have improved anti-tumor effect and reduced toxicity and may be useful for targeting mitochondria in cancer cells.

Abstract: A wood-type golf club head includes a depth in a front to rear direction no less than 80 mm, a striking face including a face center located in a virtual vertical center plane aligned with the face center and extending in the front to rear direction, a rear portion opposite the striking face, a heel portion, a toe portion opposite the heel portion, a crown, and a sole opposite the crown. The sole includes a first rail and a second rail projecting from the sole base surface and having a first length and a second length, respectively, in the front to rear direction that are less than 75% of the front to rear depth of the club head and the first rail and the second rail are entirely spaced in a heel to toe direction more than 15 mm from the virtual vertical center plane.

Abstract: The present invention relates to methods for separating enantiomers of 5-phenyl and 5-naphthyl substituted 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl)phthalazin-1(2H)-ones using N-Boc-L-phenylalanine, N-Boc-D-phenylalanine, and similar chiral acids.

Abstract: A golf club head comprises a sole portion including a sole base surface, a leading edge having a virtual vertical leading edge plane, a trailing edge having a virtual vertical trailing edge plane, and a sole width defined by a distance between the virtual vertical leading edge plane and the virtual vertical trailing edge plane. The sole portion further includes a first sole rail projecting from the sole base surface, the first sole rail having a first length, a second sole rail projecting from the sole base surface and located toe-ward of the first sole rail, the second sole rail having a second length that is less than 60% of the sole width, and a third sole rail projecting from the sole base surface and located heel-ward of the first sole rail, the third sole rail having a third length that is less than 60% of the sole width.

Abstract: Aspects of the subject disclosure may include, for example, an electrochemical apparatus, comprising a pair of electrodes each composed of an intercalation host compound (IHC), a separator disposed between the pair of electrodes, and a controller configured to control cycling of the electrochemical apparatus, wherein the pair of electrodes is configured to undergo, during the cycling, reduction-oxidation (redox) reactions in electrolyte solutions that facilitate capturing of carbon dioxide (CO2) and release of captured CO2. Additional embodiments are disclosed.

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I: or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.

Abstract: A computer system includes a physical memory having a first page table and a second page table, and an address translation module. The first page table includes primary page table entries, where each page table entry among the primary page table entries is configured to store a mapping of a virtual memory address to a physical memory address and auxiliary information. The second page table includes secondary page table entries each storing at least one further auxiliary information, where each secondary page table entry corresponds to a primary page table entry in the first page table. The address translation module is configured to, in response to receiving a request from a processor, walk through the first page table to identify a primary page table entry and consecutively identify a location of a corresponding secondary page table entry based on a location of the primary page table entry.

Abstract: A system, a method, and a computer program product for providing wearable continuous blood glucose monitoring. In some embodiments, there is provided a method that includes receiving, at a smartwatch, an alert representative of a glucose state of a host-patient coupled to a glucose sensor; detecting, at the smartwatch, a predetermined action indicative of a request to generate a glance view providing an indication of the glucose state of the host-patient; and presenting, at the smartwatch and in response to the detecting, the glance view providing the indication of the glucose state of the host-patient.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.

Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

Abstract: Examples of the present disclosure describe systems and methods for providing enhanced security in edge computing environments. A first aspect describes a method for moving security features dynamically applied to an application at a first deployment location to an application at a second deployment location. A second aspect describes a method for locally expanding/contracting an instance of a deployed application. A third aspect describes a method for redirected network traffic associated with detected malicious conduct from a first application deployment environment to a secured second application deployment environment. A fourth aspect describes a method for performing multi-stage network traffic filtering.

Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5?-monophosphate-activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

Abstract: Cooking devices and methods of cooking are provided. The cooking devices can include a housing defining an interior cooking chamber, a fan disposed within the interior cooking chamber, a smoke unit coupled to an exterior of the housing, and a smoke channel at least partially defined by a contour of the housing. The smoke unit is configured to generate smoke. The smoke channel has a first end in fluid communication with an interior of the smoke unit and a second end terminating within the interior cooking chamber proximate the fan such that a low-pressure zone created by operation of the fan causes smoke generated by the smoke unit to be drawn into the interior cooking chamber.

Abstract: An ice mold for forming hollow, elongated ice structures intended to be used as drinking straws. The ice mold includes an outer tube, an inner tube concentrically positioned within the outer tube, and top and bottom caps that fluidly seal a chamber defined between the outer tube, the inner tube, the top cap, and the bottom cap.

Abstract: In an example, there is disclosed a monolithic reputation update on a data exchange layer (DXL). According to one embodiment, designating a set of objects as good or bad can be achieved via a single administrative action by leveraging persistent client initiated connections to the DXL framework. This may enable communication of the reputation updates across a heterogeneous infrastructure, including systems potentially unreachable by the server, such as those behind a firewall or NAT.