Chuan He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: Certain embodiments are directed to compositions and methods for capture of elements in physical proximity. In certain aspects the methods comprise (a) contacting a target with a functionalized scaffold or capture agent that comprises activatable cross-linking moieties to form a target/scaffold mixture; (b) exposing the target/scaffold mixture to an activator to activate the cross-linking moieties of the dendrimer and form a cross-linked target/scaffold complex; (c) isolating the target/scaffold complexes; and (d) identify portions of the target or targets that are cross linked with the scaffold.
Abstract: The present invention relates to the field of SMT splicing belt processing equipment, and more particularly to a bonding machine for new and old SMT splicing belts. The machine comprises a supporting plate for supporting the old and new splicing belts, conveying devices for conveying the old and new splicing belts toward one another, and a bonding mechanism for bonding the old and new splicing belts together, the conveying devices and the bonding mechanism both being connected to a controller.
December 23, 2017
Date of Patent:
October 12, 2021
DONGGUAN UNIVERSITY OF TECHNOLOGY
Chuan Li, Jun Deng, Hongjiao Xu, Chuliang He
Abstract: The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA. can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA.
Abstract: Methods, compositions and kits are provided to amplify the amount of genomic methylated DNA can by subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.
Abstract: Some embodiments of the disclosure provide a method for forming a semiconductor device. The method includes: forming a plurality of semiconductor material layers on a doped substrate; removing a part of the plurality of semiconductor material layers to form an exposed doped substrate; and ion implanting a dopant into the exposed doped substrate to form a doped semiconductor structure, where the doped substrate and the doped semiconductor structure have different polarities.
Abstract: Some embodiments of the disclosure provide a semiconductor device. The semiconductor device includes: a doped substrate; a barrier layer, disposed on the doped substrate; a channel layer, disposed between the doped substrate and the barrier layer; and a doped semiconductor structure, disposed in the doped substrate, where a band gap of the barrier layer is greater than a band gap of the channel layer, and the doped substrate and the doped semiconductor structure have different polarities.
Abstract: Some embodiments of the disclosure provide a semiconductor device. The semiconductor device includes: a doped substrate; a barrier layer, disposed on the doped substrate; a channel layer, disposed between the doped substrate and the barrier layer; and a doped semiconductor structure, disposed in the doped substrate, where a band gap of the barrier layer is greater than a band gap of the channel layer, the doped substrate and the doped semiconductor structure have different polarities, and the doped substrate includes a doped silicon substrate.
Abstract: Embodiments are directed to N3-kethoxal reagents and derivatives thereof, and related methods that allow fast and reversible labeling of single-stranded nucleic acids in live cells. By way of example, one aspect is directed to a process for reversible labeling of single-stranded guanine bases in live cells, which results in an effective in vivo method for transcriptome-wide RNA secondary structure mapping and RNA G-quadruplex prediction.
Abstract: The present invention is directed to a transgenic plant and a method for producing the same. In particular, the present invention is directed to a transgenic plant or a plant cell in which a nucleic acid molecule encoding an m6A demethylase is introduced, wherein said m6A demethylase has the following two domains: i) N-terminal domain (NTD) having the function of AlkB oxidation demethylase; and ii) C-terminal domain (CTD). The present invention is also directed to a method for producing said plant, comprising introducing a nucleic acid molecule encoding an m6A demethylase into a regenerable plant cell, and regenerating a transgenic plant from the regenerable plant cell.
Abstract: A bimodal ethylene-co-1-butene copolymer consisting essentially of a higher molecular weight component and a lower molecular weight component and, when in melted form at 190 degrees Celsius, is characterized by a unique melt property space defined by a combination of high-load melt index, melt flow ratio, and melt elasticity properties. A (blown) film consisting essentially of the bimodal ethylene-co-1-butene copolymer and having improved properties. Methods of synthesizing the bimodal ethylene-co-1-butene copolymer and making the blown film. A manufactured article comprising the bimodal ethylene-co-1-butene copolymer.
August 21, 2019
June 17, 2021
Bo Liu, Chuan He, Daudi A. Abe, Roger L. Kuhlman, Ayush A. Bafna, Timothy R. Lynn
Abstract: A vehicle includes a traction battery having cells and at least one controller. The controller is programmed to charge and discharge the traction battery according to a net current for the traction battery derived from sets of temperature-based current values, each of the sets corresponding to a different one of the cells, and each of the values for a given one of the sets corresponding to a different zone of the cell.
Abstract: Described herein is a multiplex 5mC marker barcode counting (MMBC) to quantify 5mC markers in DNA, in which multiple 5mC markers could be targeted for capture and linear amplification. The inventors' method provides highly sensitive and specific quantification of multiple 5mC loci.
Abstract: The present disclosure provides a method and a vehicle control system for controlling an autonomous vehicle. The method comprises utilizing the sensor group of said vehicle to acquire data related to said vehicle, wherein said data includes the speed of said vehicle, the speed of another object ahead of said vehicle, and the distance between said vehicle and another object, determining the crash probability between said vehicle and another object according to the data related to said vehicle, calculating the total magnitude of value according to said crash probability on the basis of the prospect theory, wherein said total magnitude of value indicates the balance between the value of crash risk reduction and the value of user comfort loss, and calculating the brake force according to said total magnitude of value.
Abstract: A spray-dried zirconocene catalyst system comprising a zirconocene catalyst and a hydrophobic fumed silica, which supports the zirconocene catalyst. A spray-drying method of making same. Polyolefins; methods of making and using same; and articles containing same.
March 22, 2019
February 4, 2021
Wesley R. Mariott, Roger L. Kuhlman, Phuong A. Cao, C. Dale Lester, Chuan He, Swapnil B. Chandak, Pradeep Jain, John F. Szul
Abstract: A vehicle includes a traction battery. The vehicle further includes a controller programmed to generate a capacity estimate of the traction battery and, in response to an amount of energy supplied to the traction battery during a charge cycle being less than an estimated amount of energy stored in the traction battery during the charge cycle, detect that the capacity of the traction battery has changed and alter an operating strategy of the traction battery until the capacity estimate is updated.
Abstract: The present invention relates to methods for expanding a stem cell population, as well as other cell populations. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell and/or other cell population, particularly a hematopoietic stem cell population.
October 9, 2018
November 26, 2020
Zhenrui Li, Pengxu Qian, Linheng Li, Chuan He
Abstract: A vehicle includes a traction battery and a controller in communication with the battery and programmed to control battery charging in response to a user-selected one of a plurality of charging strategies having different charging rates based on detection of lithium plating in the battery. The charging strategies may include options for faster charging with an urgent or emergency charging strategy selectable a limited number of times to mitigate battery performance degradation associated with lithium plating. A method implemented by a vehicle controller in a vehicle having a traction battery, may include controlling, by the controller, battery charging in response to a user-selected charging strategy selected from one of a plurality of available charging strategies each having a different charging rate and displayed on a user interface in response to detection of lithium plating in the traction battery, at least one charging strategy associated with additional lithium plating if selected.
Abstract: Lithium ion battery state of charge (SOC) is a function of open circuit voltage (OCV). Battery internal diffusion process needs to be nearly completed to be able to measure battery open circuit voltage. The length of the minimum settling time depends on the battery type, usage and temperature. Described are methods to determine electric vehicle battery voltage relaxation time based on battery temperature and usage history.
Abstract: A vehicle includes a battery pack, an electric motor, and a contactor to electrically connect the pack and motor. The contactor is configured with a control circuit to electrically connect the pack and motor. The control circuit includes a leak detection sensor. The vehicle further includes a controller to output a leakage resistance associated with the pack. The leakage resistance is based on a voltage of the pack and a leak voltage detected by the sensor while the contactor is closed.
Abstract: The current disclosure provides a method that can specifically label and directly amplify 5hmC site on genomic DNA without pull-down or bisulfite treatment, which enables one to map the 5hmC site from a single DNA molecule. Aspects of the disclosure relate to a method for detecting 5-hydroxymethylcytosine (5hmC) nucleic acid bases in a nucleic acid molecule or a plurality of nucleic acid molecules, the method comprising: a. modifying the 5hmC nucleic acid base with a first functional group; b. covalently attaching a modified nucleic acid probe comprising a second functional group to the first functional group; wherein the nucleic acid probe and nucleic acid molecule are covalently linked through the first and second functional groups; c. annealing a primer to the nucleic acid probe; d. performing primer extension of the annealed primer to make a new strand; and e. detecting the new strand.