Patents by Inventor Chuan He

Chuan He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250250548
    Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.
    Type: Application
    Filed: January 8, 2025
    Publication date: August 7, 2025
    Applicants: The University of Chicago, Nationwide Children's Hospital, The Ohio State University
    Inventors: Jianrong LI, Mark E. PEEPLES, Chuan HE, Stefan NIEWIESK, Mijia LU, Miaoge XUE, Zijie ZHANG, Boxuan ZHAO
  • Publication number: 20250240558
    Abstract: A vibration damping loudspeaker includes a sound generating unit, a magnetic assembly, a connecting member and a damping member. The connecting member is symmetrically arranged at the sound generating unit. The damping member is symmetrically injection molded between the magnetic assembly and the connecting member. A main magnetic plate is not in direct contact with the connecting member and thus a distance is formed in between. Thus, in the vibration damping loudspeaker of the present disclosure, by securely coupling the connecting member to the sound generating unit and securely assembling the damping member between the connecting member and the magnetic assembly, the damping member forms a buffer between the sound generating unit and the magnetic assembly, so as to achieve effects of shock absorption and shock isolation during the operation of the vibration damping loudspeaker to prevent discomfort of a user during use of an electronic device.
    Type: Application
    Filed: October 23, 2024
    Publication date: July 24, 2025
    Applicant: FORTUNE GRAND TECHNOLOGY INC.
    Inventors: PING-YU LEE, JIAN LV, CHUAN HE, HONG-SHENG ZHANG, YU-HSI CHEN
  • Publication number: 20250229334
    Abstract: An approach for intelligent online scan sequence optimization to achieve uniform temperature distribution in LPBF using a control theoretic approach. The thermal dynamics of the LPBF process is modeled using the finite difference method and the next best feature (for example, stripe or island) that minimizes a thermal uniformity metric is found using a control theoretic approach. In simulations, the present approach yields up to 8.4 times improvement in thermal uniformity compared to existing heuristic approaches.
    Type: Application
    Filed: October 7, 2022
    Publication date: July 17, 2025
    Applicant: The Regents of the University of Michigan
    Inventors: Keval RAMANI, Chinedum OKWUDIRE, Chuan HE
  • Patent number: 12359200
    Abstract: The present invention relates to methods for expanding a stem cell population, as well as other cell populations. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell and/or other cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: July 15, 2025
    Assignees: STOWERS INSTITUTE FOR MEDICAL RESEARCH, UNIVERSITY OF CHICAGO
    Inventors: Zhenrui Li, Pengxu Qian, Linheng Li, Chuan He
  • Patent number: 12359242
    Abstract: Certain embodiments are directed to compositions and methods for capture of elements in physical proximity. In certain aspects the methods comprise (a) contacting a target with a functionalized scaffold or capture agent that comprises activatable cross-linking moieties to form a target/scaffold mixture; (b) exposing the target/scaffold mixture to an activator to activate the cross-linking moieties of the dendrimer and form a cross-linked target/scaffold complex; (c) isolating the target/scaffold complexes; and (d) identify portions of the target or targets that are cross linked with the scaffold.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: July 15, 2025
    Assignee: The University of Chicago
    Inventors: Chuan He, Qiancheng You
  • Publication number: 20250195570
    Abstract: Disclosed are compositions and methods useful for cancer treatment. The composition and methods include overexpressing BAMBI in a population of immune cells, such as myeloid-derived suppressor cells, in order to improve the immune cells immunogenic and/or anti-tumor effects. Also disclosed are compositions and methods for determining responsiveness to a radiotherapy and/or immunotherapy.
    Type: Application
    Filed: December 16, 2024
    Publication date: June 19, 2025
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Ralph WEICHSELBAUM, Hua LIANG, Chuan HE, Liangliang WANG
  • Publication number: 20250154187
    Abstract: Aspects of the present disclosure are directed to methods and compositions for modification, detection, and quantification of pseudouridine and 5-hydroxymethylcytosine. Disclosed are methods for modification of pseudouridine and/or 5-hydroxymethylcytosine comprising bisulfite treatment under particular conditions. Further disclosed are compositions and kits comprising a bisulfite solution and instructions for use.
    Type: Application
    Filed: April 27, 2022
    Publication date: May 15, 2025
    Inventors: Chuan HE, Qing DAI, Lisheng ZHANG, Chang YE
  • Publication number: 20250092449
    Abstract: Methods, compositions and kits are provided to amplify an amount of genomic methylated DNA that can be subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.
    Type: Application
    Filed: November 20, 2024
    Publication date: March 20, 2025
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Chuan HE, Boxuan Simen ZHAO, Pradnya NARKHEDE, Chang LIU, Xiaolong CUI
  • Publication number: 20250070731
    Abstract: A power amplifier circuit includes a power amplifier unit and a broadband improvement unit. The power amplifier unit includes a signal input port, a signal output port, a power transistor, and a first inductor. The power transistor is configured to perform power amplification on radio frequency signals in a plurality of frequency bands. The broadband improvement unit adjusts a parallel resonance frequency of the power amplifier unit, to reduce envelope impedance of the power amplifier unit between a first target frequency and a second target frequency. The first target frequency is a maximum frequency difference between the plurality of frequency bands, and the second target frequency is a minimum frequency difference between the plurality of frequency bands.
    Type: Application
    Filed: November 8, 2024
    Publication date: February 27, 2025
    Inventors: Yiping SUN, Chuan HE, Jie SUN
  • Publication number: 20250066837
    Abstract: Aspects of the present disclosure are directed to methods, compositions, and kits for detection and analysis of DNA and RNA cytosine methylation. Certain aspects include methods, compositions and kits useful in bisulfite sequencing of methylated nucleic acids, including methylated nucleic acids from low-input samples such as cell-free DNA and cell-free RNA. Also disclosed are methods and compositions for detection and quantification of 5-hydroxymethylcytosine in DNA.
    Type: Application
    Filed: January 6, 2023
    Publication date: February 27, 2025
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Chuan HE, Qing DAI, Iryna IRKLIYENKO, Chang YE
  • Patent number: 12227769
    Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: February 18, 2025
    Assignees: The University of Chicago, Nationwide Children's Hospital, The Ohio State University
    Inventors: Jianrong Li, Mark E. Peeples, Chuan He, Stefan Niewiesk, Mijia Lu, Miaoge Xue, Zijie Zhang, Boxuan Zhao
  • Patent number: 12226803
    Abstract: A device for separating and recovering flat-plate catalyst powder and a method for determining a wear ratio are provided. The device includes a powder separation unit and a powder recovery unit, a powder accumulation bin is respectively connected with a shell and a catalyst powder outlet, a cyclone outlet is configured on an inner side of a recovery shell, and a primary filter and a secondary filter are configured on an inner side wall of the recovery shell.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: February 18, 2025
    Assignees: HUANENG CHONGQING LUOHUANG POWER GENERATION CO., LTD, SUZHOU XIRE ENERGY SAVING ENVIRONMENTAL PROTECTION TECHNOLOGY CO., LTD.
    Inventors: Yingjie Bao, Jieyong Hao, Changkai Yu, Xun Wu, Xianchun Zhou, Yanxuan Liang, Rongfu Tang, Feiyun Chen, Bin Luo, Kaiyou Liao, Danping Zhang, Chao Li, Fanhai Kong, Lele Wang, Qiang Bao, Chuan He
  • Patent number: 12188084
    Abstract: Methods, compositions and kits are provided to amplify an amount of genomic methylated DNA that can be subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: January 7, 2025
    Assignee: The University of Chicago
    Inventors: Chuan He, Boxuan Simen Zhao, Pradnya Narkhede, Chang Liu, Xiaolong Cui
  • Publication number: 20250005774
    Abstract: A rate control device includes a confidence calculation circuit, a blend calculation circuit and a bit distribution circuit. The confidence calculation circuit calculates a texture confidence, a person confidence and a motion confidence according to an image. The blend calculation circuit determines, according to a mode selection signal, whether to select one of the person confidence and the motion confidence for blend calculation with the texture confidence to generate a blend parameter. The bit distribution circuit generates a bit distribution parameter according to the blend parameter.
    Type: Application
    Filed: June 5, 2024
    Publication date: January 2, 2025
    Inventors: Chuan HE, Yu YE, Ling-Ying NAIN
  • Publication number: 20250000838
    Abstract: This disclosure relates to uses of inhibitors of YTH family proteins in the management of fragile X syndrome, fragile X-associated disorders, cognitive disorders, developmental disorders, or central nervous system (CNS) disorders. In certain embodiments, this disclosure relates to treating fragile X syndrome, fragile X-associated disorders, cognitive disorders, developmental disorders, or central nervous system (CNS) disorders by administering an effective amount of an inhibitor of YTHDF1 to a subject in need thereof. In certain embodiments, the YTHDF1 inhibitor is a small molecule inhibitor such as salvianolic acid C, derivatives, prodrugs, esters, or salts thereof.
    Type: Application
    Filed: October 13, 2022
    Publication date: January 2, 2025
    Inventors: Peng Jin, Chuan He, Zhongyu Zou
  • Publication number: 20240430621
    Abstract: A vibration damping loudspeaker includes a sound-generating unit, a magnetic member, an assembly-auxiliary frame and dampers. Aligning units of the assembly-auxiliary frame are coupled to positioning units of the sound-generating unit. The dampers are symmetrically disposed between the magnetic member and the assembly-auxiliary frame. The sound-generating unit and the magnetic member can be quickly and easily mounted in place because of the assembly-auxiliary frame to not only enhance the production yield of the vibration damping loudspeaker but also allow the dampers to function as a buffer between the sound-generating unit and the magnetic member, so as to achieve vibration damping and vibration isolation during the operation of the vibration damping loudspeaker to spare users the discomfort they will otherwise experience for using electronic devices.
    Type: Application
    Filed: June 19, 2024
    Publication date: December 26, 2024
    Applicant: FORTUNE GRAND TECHNOLOGY INC.
    Inventors: PING-YU LEE, JIAN LV, CHUAN HE, MING-JUN ZENG, HONG-SHENG ZHANG, DE-WU WANG, ZHI-LONG NIU
  • Patent number: 12173108
    Abstract: A method of independently changing a melt rheology property value of a bimodal polyethylene polymer being made using a bimodal catalyst system in a single gas phase polymerization reactor. The method comprises process conditions comprising alkane(s) in the reactor. The method comprises a bimodal catalyst system that is characterized by an inverse response to alkane(s) concentration. The method comprises changing concentration of the alkane(s) in the reactor by an amount sufficient to effect a measurable change in the melt rheology property value; wherein the bimodal catalyst system is characterized by an inverse response to alkane(s) concentration such that when the alkane(s) concentration is increased, the melt rheology property value of the resulting bimodal polyethylene polymer is decreased, and when the alkane(s) concentration is decreased, the melt rheology property value of the resulting bimodal polyethylene polymer is increased.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: December 24, 2024
    Assignee: UNIVATION TECHNOLOGIES, LLC
    Inventors: Chuan He, Timothy R. Lynn, Robert N. Reib, Bo Liu
  • Patent number: 12166102
    Abstract: A nitride-based semiconductor device includes a substrate, a buffer, a first nitride-based semiconductor layer, a second nitride-based semiconductor layer, a S/D electrode, a second S/D electrode, and a gate electrode. The buffer is disposed over the substrate and includes at least one layer of a nitride-based semiconductor compound doped with an acceptor at a top-most portion of the buffer. The first and second nitride-based semiconductor layers are disposed over the buffer. The first S/D electrode is disposed over the second nitride-based semiconductor layer, in which the first S/D electrode extends downward to a position lower than the first nitride-based semiconductor layer, so as to form at least one first interface with the top-most portion of the buffer, making contact with the at least one layer of the nitride-based semiconductor compound. The second S/D electrode and the gate electrode are disposed over the second nitride-based semiconductor layer.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: December 10, 2024
    Assignee: INNOSCIENCE (SUZHOU) TECHNOLOGY CO., LTD.
    Inventors: Ronghui Hao, Fu Chen, Chuan He, King Yuen Wong
  • Publication number: 20240401121
    Abstract: The disclosure is directed to universal hairpin primer (UHP) nucleic acid molecules for quantifying RNA, including mature microRNA (miRNA), messenger RNA (mRNA), and long noncoding RNA (lncRNA), as well as systems and methods for using same. The UHP nucleic acid molecules comprise a stem-loop structure and a degenerate nucleic acid sequence of 2-10 (e.g., 2-6) nucleotides at the 3? end, wherein the degenerate nucleic acid sequence hybridizes to the 3?-end of an RNA molecule. The RNA quantification analysis can be carried out by using either the conventional SYBR Green system or the cost-effective universal TaqMan probe-based RT-qPCR system.
    Type: Application
    Filed: September 28, 2022
    Publication date: December 5, 2024
    Inventor: Tong-Chuan HE
  • Patent number: 12154968
    Abstract: A nitride-based semiconductor device includes a first nitride-based semiconductor layer, a second nitride-based semiconductor layer, a source electrode, a drain electrode, a gate electrode a first strain-compensating layer, and a first protection layer. The second nitride-based semiconductor layer is disposed on the first nitride-based semiconductor layer and has a bandgap greater than a bandgap of the first nitride-based semiconductor layer. The source electrode and the drain electrode are disposed above the second nitride-based semiconductor layer. The gate electrode is disposed between the source and drain electrodes. The first strain-compensating layer is disposed above the second nitride-based semiconductor layer and between the drain and gate electrodes.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: November 26, 2024
    Assignee: INNOSCIENCE (SUZHOU) TECHNOLOGY CO., LTD.
    Inventors: Ronghui Hao, Chuan He, King Yuen Wong