Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.

Abstract: Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining genetically modified NE neurons expressing a NE sensor or a TH-reporter, and methods for using NE neurons obtained according to the methods of this disclosure.

Abstract: A project light device comprises multiple light assemblies and at least one pivotable connecting assembly. The at least one pivotable connecting assembly is connected between two adjacent light assemblies. Each light assembly comprises a shell, and a light-emitting module and a light-concentrating structure that are mounted inside the shell. The light-concentrating structure concentrates light emitted from the light-emitting module to project light out of the shell. The at least one pivotable connecting assembly comprises a joint seat, a middle pivotable rod and a joint rod. The joint seat and the joint rod are respectively mounted at two adjacent light assemblies. The joint rod is pivotably mounted at the middle pivotable rod pivotably mounted at the joint seat. The two adjacent light assemblies are connected through the pivotable connecting assembly, thereby being pivotable relative to each other, so the light assemblies project lights to different directions.

Abstract: The present invention disclose a clock synchronization method. By the operations of: receiving a plurality of data packets sent by a host and acquiring receiving time when each data packet is received and a sending interval at which each two adjacent data packets are sent, wherein each data packet comprises a packet sequence and a first packet timestamp when the first data packet is sent; carrying out screening processing on all data packets according to the sending interval and the receiving time and packet sequence of each data packet so as to obtain at least one valid data packet; obtaining a time compensation value according to the receiving time and packet sequence of each valid data packet, the first packet timestamp, and the sending interval; and adjusting time of a slave according to the time compensation value so as to realize clock synchronization between the slave and the host.

Abstract: Systems and methods are disclosed herein for monitoring health of each switch of a plurality of switches on a network by selectively mirroring packets transmitted by each switch of the plurality of switches. In some embodiments, control circuitry generates a plurality of mirroring parameters, each mirroring parameter comprising an instruction to mirror a respective type of packet. The control circuitry transmits the plurality of mirroring parameters to each switch of the plurality of switches on the network, and receives, from a switch, a packet that was mirrored by the switch according to a mirroring parameter of the plurality of mirroring parameters. The control circuitry determines the respective type of the packet, executes an analysis of contents of the packet based on the respective type of the packet, and determines a health of the switch based on results of the analysis.

Abstract: A side projector light has a bottom lid, an upper lid, and a side hollowed-out plate. The bottom lid has multiple first holes and multiple second holes, and the first holes and the second holes are formed on the bottom lid. The upper lid has multiple third holes and multiple first columns, and the third holes and the first columns are formed on the upper lid. The side hollowed-out plate is mounted between the upper lid and the bottom lid and has multiple second columns. The second columns extend toward the upper lid and the bottom lid. The first columns are connected to the first holes, so that the upper lid is capable of connecting the bottom lid. The second columns connect the second holes and the third holes, so that the side hollowed-out plate is capable of connecting the upper lid and the bottom lid.

Abstract: The present disclosure relates to the preparation of synthetic cannabinol and homologs thereof having the structure of Formula (I), wherein, n is 1, 2, 3 or 4. The methods described herein provide for high yields and purity in a one-pot synthesis or high yields and purity without the need for lengthy column chromatography. The present disclosure also relates to solid forms of cannabinol.

Abstract: Mitigation of controls set packing includes generating an Observability Don't Care (ODC) expression for a target register of a circuit design. The target register has an original reset signal that is a constant. A plurality of supports of the ODC expression that are driven by driver registers are grouped into a plurality of groups. Each group of the plurality of groups includes only supports that are driven by driver registers having a same reset signal. A control set of each group is different from a control set of the target register. The reset signal of a selected group of the plurality of groups is designated as a candidate reset signal for the target register based on an evaluation of the ODC expression. The circuit design is modified by connecting the candidate reset signal to the target register in place of the original reset signal.

Abstract: Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining genetically modified NE neurons expressing a NE sensor or a TH-reporter, and methods for using NE neurons obtained according to the methods of this disclosure.

Abstract: Provided herein are methods for producing neuroectoderm and retinal progenitor cells from pluripotent stem cells, and compositions of retinal progenitor cells produced thereby.

Abstract: A double image projection lamp has a housing, a first and a second projecting assembly in the housing, a driver, a light shielding element, and a driven component. The second projecting assembly has a shell body pivotally connected to the housing, connected to the driver, and having a sliding groove between a projecting end of the shell body and a light emitting unit of the second projecting assembly. The light shielding element is disposed in the sliding groove. When the driver drives the shell body to pivot, the driven component is driven by the shell body and drives the light shielding element to move along the sliding groove so as to allow light emitted from the light emitting unit to be shielded by the shielding element or travel to the projecting end, which provides fade-in and fade-out visual effects when two projected images move relatively.

Abstract: The present disclosure relates to the preparation of synthetic cannabinoid derivatives of Formulae I and II, and compositions made therefrom.

Abstract: A vehicle charging system comprises at least one controller and at least one arm, each arm having a first end coupled to an actuator and a second end comprising a charging interface. The actuator is configured to articulate the arm into a charging position. The charging interface comprises at least one charging contact coupled to a power source and configured to engage and deliver power to a vehicle charging interface to charge at least one battery of a vehicle. The charging system can include a plurality of arms, each configured to charge a different vehicle. A method of charging one or more vehicles using the charging system is also provided.

Abstract: The present invention discloses a highly integrated R-wave triggered tumor therapy apparatus, and relates to the technical field of medical devices for ablation of tumors. The apparatus includes: a human body R-wave detection module for detecting a human body R-wave signal; a signal generator for obtaining a narrow pulse signal with nanometer width according to the human body R-wave signal; a primary matching circuit; and a high-frequency transformer; where the primary matching circuit is used for matching the narrow pulse signal with nanometer width to an input side of the high-frequency transformer, so that the high-frequency transformer outputs a high-voltage signal needed for treatment of human bodies.

Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.

Abstract: Control set optimization for a circuit design includes generating, by a processor, Observability Don't Care (ODC) expressions for registers of the circuit design. Redundant reset pins of the registers of the circuit design are determined by the processor by iteratively checking, on a per-cube and a per-literal basis for each ODC expression, whether a value of a literal causes the ODC expression to evaluate to 1. A modified version of the circuit design is generated by the processor by connecting one or more reset pins of the set of redundant reset pins to one or more constants.

Abstract: A transport vehicle, such as a vision guided vehicle, can comprise a drive portion constructed to facilitate movement of the transport vehicle and a load portion constructed to engage an object of interest. The load portion can comprise an object engagement apparatus and at least one sensor coupled to or disposed within a distal end of the object engagement apparatus, wherein the sensor can be at least a 2D sensor. The engagement apparatus can comprise forks, at least one fork having sensor coupled to or disposed within a fork tip. The 2D sensor can comprise a scanning LIDAR sensor arranged to collect information to identify a pickable pallet, for example.

Abstract: A vehicle charging system comprises at least one controller and at least one arm, each arm having a first end coupled to an actuator and a second end comprising a charging interface. The actuator is configured to articulate the arm into a charging position. The charging interface comprises at least one charging contact coupled to a power source and configured to engage and deliver power to a vehicle charging interface to charge at least one battery of a vehicle. The charging system can include a plurality of arms, each configured to charge a different vehicle. A method of charging one or more vehicles using the charging system is also provided.

Abstract: A chuck for gripping a workpiece includes: a chuck body; a jaw connected to the chuck body for constrained movement relative to the chuck body along a jaw path in jaw-closing and jaw-opening directions; an actuator body connected to the chuck body for constrained movement relative to the chuck body along an actuator path; and a slider body connected to the chuck body for constrained movement relative to the chuck body along a slider body path. The slider body is connected to the jaw for constrained movement relative to the jaw along a slider-body-to-jaw path. The slider body is connected to the actuator body for constrained movement relative to the actuator body along a slider-body-to-actuator-body path.