Abstract: The invention relates to antibodies and antigen-binding fragments thereof that recognize coronavirus spike proteins(CoV-S), such as the spike protein of Middle East respiratory syndrome coronavirusspike protein(MERS-S). In some embodiments, the antibodiesbind to CoV-S with high affinity, inhibit CoV infection of human cells, inhibit CoV sialic acid-binding activity and/or bind to multiple types of CoV-S. In some embodiments, the antibodies provide a means of preventing, treating or ameliorating CoV infection.

Abstract: Disclosed are a Liang Di Tang water-extracted liquid, a Liang Di Tang water-extracted paste, and a Liang Di Tang preparation, and preparation methods thereof, and a quality control standard for the Liang Di Tang preparation. The preparation method of Liang Di Tang water-extracted liquid includes: mixing five traditional Chinese medicines with water, and conducting soaking and then extraction three times, concentrating extraction solutions obtained separately at a temperature independently of 70° C. to 90° C., a vacuum degree independently of 0.03 MPa to 0.07 MPa, and a steam pressure independently of not larger than 0.09 MPa, and mixed concentrates obtained to obtain the Liang Di Tang water-extracted liquid, where the five traditional Chinese medicines are wine-processed Rehmanniae Radix, Scrophulariae Radix, wine-processed Paeoniae Radix Alba, Ophiopogon japonicus, and Lycii Cortex.

Abstract: Provided are preparation methods of a Zhu Ling Tang extract solution, a Zhu Ling Tang extract paste, and a Zhu Ling Tang solid preparation. A method for preparing the Zhu Ling Tang extract solution includes: soaking four traditional Chinese medicines in first water to obtain a presoaked material solution, conducting a first boiling extraction on the presoaked material solution to obtain a first aqueous extract solution and a medicine residue; mixing the medicine residue with second water, and conducting a second boiling extraction to obtain a second aqueous extract solution; conducting a first concentration on the first aqueous extract solution to obtain a first concentrate; and combining the first concentrate with the second aqueous extract solution, and conducting a second concentration to obtain a second concentrate; and mixing the second concentrate and an aqueous solution of Asini Corii Colla to obtain the Zhu Ling Tang extract solution.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: An electric truck steer-by-wire system and a net-work uncertainty control method therefor. Said system comprises: a master control electric power module (14), a slave control electric power module (18), a road-sensing motor module (4), a steering wheel (1), an upper steering column (3), a lower steering column (10), a rack and pinion steering mechanism (12), wheels (13), a first steering angle sensor (2), a second steering angle sensor (11), a steering domain controller (8), and a vehicle-mounted CAN network (9). By means of the design of the master and slave controllers and actuating mechanisms, the system combines the advantages of steering angle tracking, torque tracking and current tracking, there-by satisfying the steering response requirements and power requirements of the electric truck, and further enhancing the robustness and fault-tolerant performance of the system under a random network time lag.

Abstract: An active fault tolerance and fault mitigation system based on steer-by-wire dual motors and a mode switching control method thereof are provided. The system includes an acquisition unit, a steering wheel assembly, an ECU control module, a front wheel steering assembly, and a fault tolerance controller (18) which are sequentially connected. The acquisition unit transmits an acquired vehicle signal to the ECU control module, and then a corresponding compensation strategy is selected by means of a fault tolerance control strategy unit, a yaw rate calculation unit, a stability control unit, and a dual-motor compensation unit to act on a rack and pinion mechanism (15). The system and method can perform switching in an active fault tolerance and fault mitigation mode to achieve optimal control of the real-time performance of a vehicle, thereby ensuring the driving performance and higher performance of the vehicle in a field fault condition.

Abstract: Disclosed are a drive-by-wire chassis cyber-physical system under an intelligent traffic environment and a control method. The system includes: an SoS-level CPS, a system-level CPS, and a unit-level CPS, data transmission is realized between a plurality of unit-level CPSs and one system-level CPS, and data transmission is realized between a plurality of system-level CPSs and one SoS-level CPS. The system integrates a hub motor with a suspension, cancels traditional structures such as an engine and a clutch, and simplifies the structure of a chassis. A motor directly drives a vehicle to run, and different driving, braking or torque is applied to different wheels through four hub motors, so as to meet independent control of the wheels and improve active safety and operational stability.

Abstract: A multifunctional electric recirculating ball steering system for commercial vehicles and its control method are described. The system comprises three modules: an electric power module, a mechanical transmission module, and a control module. The system introduces a dual-rotor motor and a common power motor, working together to act on the input end of a recirculating ball steering gear. The dual-rotor motor offers high redundancy, increased output torque, and improved reliability for control-by-wire operations. A fork assembly enables synchronous and asynchronous rotation of the dual rotors, achieving both steer-by-wire and electric power steering functions. Leveraging the high reduction ratio capability of the recirculating ball steering gear maximizes power torque and simplifies the system architecture while ensuring reliability in both traditional control and control-by-wire functionalities.

Abstract: The present invention relates to a thickener composition comprising a hydrophobically modified alkylene oxide polyurethane obtained by reacting a water-soluble polyalkylene glycol, a diisocyanate and a polyester end-capping agent which is a reaction product of a lactone compound and a monhydroxy compound. The present invention further relates to a process for the preparation of the hydrophobically modified alkylene oxide polyurethane.

Abstract: Disclosed are a drive-by-wire chassis cyber-physical system under an intelligent traffic environment and a control method. The system includes: an SoS-level CPS, a system-level CPS, and a unit-level CPS, data transmission is realized between a plurality of unit-level CPSs and one system-level CPS, and data transmission is realized between a plurality of system-level CPSs and one SoS-level CPS. The system integrates a hub motor with a suspension, cancels traditional structures such as an engine and a clutch, and simplifies the structure of a chassis. A motor directly drives a vehicle to run, and different driving, braking or torque is applied to different wheels through four hub motors, so as to meet independent control of the wheels and improve active safety and operational stability.

Abstract: Disclosed are a multifunctional electric recirculating ball steering system for commercial vehicles and a control method thereof, including: an electric power module, a mechanical transmission module and a control module; the electric power module includes: a dual-rotor motor module (14) and a power motor (22); the mechanical transmission module includes: a steering wheel (1), a steering shaft (4), couplings (5), a recirculating ball steering gear (16), a gear sector (19), a gear sector shaft (6), a steering drag link (7), a steering tie rod (12), a steering knuckle arm (8), a left tie rod arm (11), a right tie rod arm (26), a left steering knuckle (10), a right steering knuckle (25), a left wheel (9) and a right wheel (24); and the control module includes: an electronic control unit (21), torque sensors (3), a vehicle speed sensor (20), a steering angle sensor (2) and current sensors (23). The system ensures system reliability.

Abstract: The present invention relates to linkers having a group of propioloyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: Methods, compositions, and kits for predicting and controlling fruit color in palm.

Abstract: A method for preparing a gel product instant-dissolving block includes: adding water into a raw material to dissolve the raw material and carrying out concentrating to obtain a gel solution; carrying out a drying treatment on the gel solution to obtain an irregular cellular gel body; grinding the gel body and carrying out screening to obtain gel powder with a particle size being equal to or larger than 80 meshes; moistening the gel powder with 85 to 95% alcohol and carrying out compression at a compression ratio of 30% to 60% to obtain a block, thereby obtaining the gel product instant-dissolving block. The gel product instant-dissolving block of the present invention has a loose pore structure at the inside, has a high superficial area/volume ratio and has a product density of 0.4 to 0.8 g/cm3, and is capable of being rapidly dissolved within 2 minutes in hot water.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.