Abstract: The present invention concerns molecularly imprinted polymers (MIPs) having an affinity for natriuretic peptides, such as atrial natriuretic peptide (ANP). In some embodiments, the MIP is a nanoparticle (a molecularly imprinted polymeric nanoparticle (MIPNP)). Other aspects of the invention include methods of preparing an MIP having affinity for a natriuretic peptide, methods for binding a natriuretic peptide in vitro or in vivo using an MIP of the invention, methods for interfering with the binding of a natriuretic peptide with its receptor in vivo, methods for reducing inflammation, cell growth, cell differentiation, or a cell proliferation disorder, methods for detecting natriuretic peptides, and devices and kits for sequestering and/or detecting natriuretic peptides.

Abstract: Disclosed herein are theranostic nanoparticles configured for simultaneous delivery of a diagnostic moiety, drug moiety, and a gene therapy moiety. In one embodiment, the theranostic nanoparticles contain a super paramagnetic iron oxide chemotherapeutic loaded on a chitosan functionalized 2D graphene sheet with a gene therapy moiety attached to the surface of the chitosan functionalized 2D graphene sheet. Also disclosed are methods for making and administering theranositic nanoparticles configured for simultaneous delivery of a diagnostic moiety, drug moiety, and a gene therapy moiety.

Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.

Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.

Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.

Abstract: Provided herein are hydrogel compositions containing graphene, chitosan, a polyethylene (glycol) diacrylate (PEGDA). The hydrogel can optionally contain an N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided are methods for differentiating a cell on the hydrogels described herein. Further provided herein are methods for delivering a compound via the hydrogels described herein.

Abstract: Disclosed the use of gelatin or deeply processed gelatin materials in the preparation of hair quality-improving compositions.

Abstract: One embodiment of the present application discloses an POI displaying method for displaying information of at least one POI (point of interest) stored in a database on an electronic apparatus. The method comprises: (a) obtaining at least one POI according to a desired POI type; (b) obtaining at least one corresponding path according to the position of each obtained POI; (c) generating a POI gathering information of each corresponding path according to the at least one obtained POI; and (d) displaying the at least one corresponding path and the corresponding POI gathering information.

Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.

Abstract: Methods, compositions, and kits for predicting and controlling fruit color in palm.

Abstract: The present invention concerns molecularly imprinted polymers (MIPs) having an affinity for natriuretic peptides, such as atrial natriuretic peptide (ANP). In some embodiments, the MIP is a nanoparticle (a molecularly imprinted polymeric nanoparticle (MIPNP)). Other aspects of the invention include methods of preparing an MIP having affinity for a natriuretic peptide, methods for binding a natriuretic peptide in vitro or in vivo using an MIP of the invention, methods for interfering with the binding of a natriuretic peptide with its receptor in vivo, methods for reducing inflammation, cell growth, cell differentiation, or a cell proliferation disorder, methods for detecting natriuretic peptides, and devices and kits for sequestering and/or detecting natriuretic peptides.

Abstract: Provided herein is a micelle composition comprising a polyethylene glycol (PEG), a DC-cholesterol, and a dioleoylphosphatidyl-ethanolamine (DOPE) and either or both a pharmaceutical compound core and a polynucleotide coating. Also provided herein is a method of administering one or more compounds to a cell comprising administering to the cell a micelle composition comprising 1) PEG-PE, a DC-cholesterol, and DOPE, and 2) the one or more compounds, wherein the compounds are selected from the group consisting of a polynucleotide and a pharmaceutical composition. Further provided are methods for detecting the micelle composition.

Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.

Abstract: Provided herein is a method of transfecting a brain cell of a subject with a polynucleotide comprising systemically administering to the subject a composition comprising a micelle having a hydrophobic superparamagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising the polynucleotide, wherein the subject has a mild traumatic brain injury.

Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.

Abstract: One embodiment of the present application discloses an POI displaying method for displaying information of at least one POI (point of interest) stored in a database on an electronic apparatus. The method comprises: (a) obtaining at least one POI according to a desired POI type; (b) obtaining at least one corresponding path according to the position of each obtained POI; (c) generating a POI gathering information of each corresponding path according to the at least one obtained POI; and (d) displaying the at least one corresponding path and the corresponding POI gathering information.

Abstract: A method for searching a database for at least a recorded location data set includes: (a) deciding at least one facility availability condition; (b) searching the database for at least a specific recorded location data set matching the facility availability condition; and (c) displaying the specific recorded location data set found in the database that matches the facility availability condition.

Abstract: There is described a method and circuit for amplifying an input current signal to provide an output current signal according to a predetermined gain profile. The method and circuit can be used for designing current-mode circuits employing MOS transistors or other kinds of electronic device that have three or more terminals. The circuit can operate with sub-nA currents, provide a very high current gain, and dissipate very low power. The structure of the circuit is simple and the transistors used do not have to have a large geometrical size. The capacitive loads are minimized and the operation speed is thus maximized with the minimum power dissipation.

Abstract: A method for reducing charge injection from a field effect transistor switch in a circuit being controlled by a timing signal having an operation cycle with at least a first phase and a second phase. A charge density is changed in at least one layer in a channel in the switch when the timing signal begins its operational cycle and is in the first phase. A depth of the layer is significantly reduced while the timing signal is still in the first phase before a transition of the timing signal from the first phase to the second phase. The timing signal is transitioned from the first phase to the second phase while the layer is significantly reduced.

Abstract: A method for reducing charge injection from a field effect transistor switch in a circuit being controlled by a timing signal having an operation cycle with at least a first phase and a second phase. A charge density is changed in at least one layer in a channel in the switch when the timing signal begins its operational cycle and is in the first phase. A depth of the layer is significantly reduced while the timing signal is still in the first phase before a transition of the timing signal from the first phase to the second phase. The timing signal is transitioned from the first phase to the second phase while the layer is significantly reduced.