Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: The present invention relates to linkers having a group of propiolyl, substituted acryl(acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Abstract: An active fault tolerance and fault mitigation system based on steer-by-wire dual motors and a mode switching control method thereof are provided. The system includes an acquisition unit, a steering wheel assembly, an ECU control module, a front wheel steering assembly, and a fault tolerance controller (18) which are sequentially connected. The acquisition unit transmits an acquired vehicle signal to the ECU control module, and then a corresponding compensation strategy is selected by means of a fault tolerance control strategy unit, a yaw rate calculation unit, a stability control unit, and a dual-motor compensation unit to act on a rack and pinion mechanism (15). The system and method can perform switching in an active fault tolerance and fault mitigation mode to achieve optimal control of the real-time performance of a vehicle, thereby ensuring the driving performance and higher performance of the vehicle in a field fault condition.

Abstract: A data configuration method includes receiving a control packet sent by a control device, where the control packet is generated by the control device based on a yet another next generation (YANG) model and includes a configuration fragment, parsing the control packet to obtain the configuration fragment, and parsing the configuration fragment based on the general module to obtain a configuration command line, and executing the configuration command line.

Abstract: A method for preparing a gel product instant-dissolving block includes: adding water into a raw material to dissolve the raw material and carrying out concentrating to obtain a gel solution; carrying out a drying treatment on the gel solution to obtain an irregular cellular gel body; grinding the gel body and carrying out screening to obtain gel powder with a particle size being equal to or larger than 80 meshes; moistening the gel powder with 85 to 95% alcohol and carrying out compression at a compression ratio of 30% to 60% to obtain a block, thereby obtaining the gel product instant-dissolving block. The gel product instant-dissolving block of the present invention has a loose pore structure at the inside, has a high superficial area/volume ratio and has a product density of 0.4 to 0.8 g/cm3, and is capable of being rapidly dissolved within 2 minutes in hot water.

Abstract: Methods, compositions, and kits for predicting and controlling fruit color in palm.

Abstract: It involves the field of power trading technology and a method for microservice transformation of power trading function comprising the following steps: (1) divide the function in extranet trading cloud into many multiple individual micro services and divide the function in intranet trading cloud into multiple individual micro services; (2) register a node information for each individual micro service in service registry when service deployment starts; (3) extranet users and intranet users enter into extranet trading cloud and intranet trading cloud respectively through PC terminal or mobile terminal, obtain the actual network address that needs to be served from service registry, send a request to the requested service, and perform related business operation.

Abstract: Methods, compositions, and kits for predicting and controlling fruit color in palm.

Abstract: The invention involves the field of power trading and especially involves a method for construction of power trading index system based on big data technology. Main steps are as follows: 1. data acquisition; 2. construction of index system: construction of index system is mainly based on cloud focus evaluation method to solve the problem of variables transformation and make data analysis through high concurrency distributed computing power of Spark memory access; 3. index calculation: adopt objective weighting approach to determine the weight of each index after index configuration and then adopt cloud focus evaluation method to calculate the weighted deviation of each index; store final evaluation result of each index into HDFS database after Spark calculation; 4. index display.

Abstract: It involves the field of power trading technology and a method for microservice transformation of power trading function comprising the following steps: (1) divide the function in extranet trading cloud into many multiple individual micro services and divide the function in intranet trading cloud into multiple individual micro services; (2) register a node information for each individual micro service in service registry when service deployment starts; (3) extranet users and intranet users enter into extranet trading cloud and intranet trading cloud respectively through PC terminal or mobile terminal, obtain the actual network address that needs to be served from service registry, send a request to the requested service, and perform related business operation.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A self-moving device moves and works in a defined working region. The self-moving device includes an energy module supplying energy to the self-moving device and a battery mounting portion used to accommodate the energy module. The battery mounting portion includes a housing, an accommodating cavity defined by the housing, a support accommodated in the accommodating cavity, and a battery accommodating portion located in the accommodating cavity and used to accommodate a battery pack. A connection relationship between the housing and the support at least includes two different connection states. The battery accommodating portion has different volumes or sizes in the two different connection states.

Abstract: A magnetic piston shoe pair for an axial piston pump and the motor includes: pistons, coil suites, piston shoes and a swash plate, wherein the interior of the coil suite is a closed coil; the bearing surface that the end surface of the swash plate abuts the piston shoe is provided with micro-molding holes; the micro-molding holes are hemispherical; the back surface of the swash plate is provided with a primary iron core and two secondary iron cores; the iron cores are wound with coil; the coil is connected to an external alternating current power supply. When the pump/motor is working, the coil is energized to generate a magnetic field, thereby adsorbing the piston shoe on the swash plate. Meanwhile, the coil suite generates an inductive magnetic field.

Abstract: A magnetic piston shoe pair for an axial piston pump and the motor includes: pistons, coil suites, piston shoes and a swash plate, wherein the interior of the coil suite is a closed coil; the bearing surface that the end surface of the swash plate abuts the piston shoe is provided with micro-molding holes; the micro-molding holes are hemispherical; the back surface of the swash plate is provided with a primary iron core and two secondary iron cores; the iron cores are wound with coil; the coil is connected to an external alternating current power supply. When the pump/motor is working, the coil is energized to generate a magnetic field, thereby adsorbing the piston shoe on the swash plate. Meanwhile, the coil suite generates an inductive magnetic field.

Abstract: The present disclosure provides a dual-shaft structure which comprises a first shaft, a second shaft being arranged beside the first shaft, and a slider. The first shaft has a protruding first stop pin. The second shaft has a protruding second stop pin. The slider includes a first spiral slot and a second spiral slot. In response to a rotation of the first shaft, the first stop pin travels along the first spiral slot to move the slider linearly along an axial direction of the first shaft. In response to the linear movement of the slider, the second shaft rotates with the first shaft through an interaction between the second spiral slot and the second stop pin.

Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.

Abstract: A connection structure and an electronic device having the same are provided. The connection structure comprises a first driving unit including a first gear and a second gear that are connected coaxially, a radius of the first gear being different from a radius of the second gear; a second driving unit coupled to the first driving unit; a first rotation shaft operatively coupled to the first driving unit; and a second rotation shaft operatively coupled to the second driving unit. The first rotation shaft and the second rotation shaft rotate synchronously via actions of the first driving unit and the second driving unit.

Abstract: Provided herein is a method of transfecting a brain cell of a subject with a polynucleotide comprising systemically administering to the subject a composition comprising a micelle having a hydrophobic superparamagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising the polynucleotide, wherein the subject has a mild traumatic brain injury.

Abstract: Disclosed the use of gelatin or deeply processed gelatin materials in the preparation of hair quality-improving compositions.