Abstract: The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject.

Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.

Abstract: The invention relates to a method in a reporting communications node (12, 14) for detecting usage of a resource within a radio access network. The reporting communication node (12, 14) is comprised within a radio communications network (1) in which radio communications network (1) a user equipment (12) is served. The reporting communications node monitors a performance measurement per user equipment of the user equipment (12), which performance measurement indicates usage of resources within a radio access network. The reporting communication node detects when the performance measurement per user equipment of the user equipment (12) goes beyond a threshold value over a preset period of time. In addition, the reporting communication node reports to a different communication node (14, 15) or within the communication node (12, 14), the performance measurement per user equipment when the performance measurement per user equipment goes beyond the threshold value.

Abstract: In some embodiments herein a method in a first communication device (10) for determining a power mode for a base station to enter is disclosed. The first communication device (10) determines cell load indicating user equipment activity within a first local cell A of the base station. Furthermore, the first communication device (10) receives cell load information from a second communication device (20) comprising an indication of user equipment activity within a second cell B associated to the second communication device (20), and determines the power mode for the base station to enter based on—the received cell load information and the determined load in the first local cell (A).

Abstract: Method for retrieving data from an object database stored in a server (220) as a network (501) of objects (502) connected via links (503), said method including the steps of: storing (301) said object database in a server (220); forming (302) at a client (210) a request for a requested object (903) of a predetermined identity in said database and objects (904) connected to said requested object (903); transmitting (303) said request from said client (210) to said server (220) over a computer network (230); creating a data package containing said requested object (903) and objects connected to said requested object; and transmitting (306) said data package to said client. The invention furthermore relates to a system for retrieving data from an object database, a server, a computer program, a computer program product and a computer system.

Abstract: A turning tool including a basic body having an insert seat, an indexable turning insert having a triangular basic shape, and a tightening element fixing the turning insert in the insert seat. The insert includes an upperside and an underside between which three side surfaces extend that are situated in a first imaginary, equilateral triangle and therefore converge in pairs at an angle of 60° toward corners in which cutting edges are included. The turning insert is engaged with the insert seat via an interface that includes elongate and straight, female-like and male-like engagement members, which are in engagement with each other in order to prevent turning of the turning insert. The insert seat includes a supporting surface having a corner section against which an active corner of the turning insert is applied.

Abstract: In a method and a device a detection mechanism enabling a cellular radio system to detect deployment of two or more radio base stations having a small coverage area close to each other and configured to use the same scrambling code is provided. The detected information can be used as a trigger to automatically reconfigure one of the radio base stations having a small coverage area.

Abstract: A tool for chip removing machining, including a basic body, and a cutting insert fixed in an insert seat in the basic body by a tightening element, and which, via at least one shoulder surface, is held pressed against a stop surface in the insert seat. An elastically deformable spring is arranged in the insert seat, which provides, by elastic deformation as a result of tightening of the tightening element, the pressing of the shoulder surface against the stop surface.

Abstract: A turning tool including a basic body having an insert seat, an indexable turning insert having a triangular basic shape, and a tightening element fixing the turning insert in the insert seat. The insert includes an upperside and an underside between which three side surfaces extend that are situated in a first imaginary, equilateral triangle and therefore converge in pairs at an angle of 60° toward corners in which cutting edges are included. The turning insert is engaged with the insert seat via an interface that includes elongate and straight, female-like and male-like engagement members, which are in engagement with each other in order to prevent turning of the turning insert. The insert seat includes a supporting surface having a corner section against which an active corner of the turning insert is applied.

Abstract: A turning tool including a basic body having an insert seat, an indexable turning insert having a triangular basic shape, and a tightening element fixing the turning insert in the insert seat. The insert includes an upperside and an underside between which three side surfaces extend that are situated in a first imaginary, equilateral triangle and therefore converge in pairs at an angle of 60° toward corners in which cutting edges are included. The turning insert is engaged with the insert seat via an interface that includes elongate and straight, female-like and male-like engagement members, which are in engagement with each other in order to prevent turning of the turning insert. The insert seat includes a supporting surface having a corner section against which an active corner of the turning insert is applied.

Abstract: A turning tool including a basic body having a pocket, a shim plate mounted in the pocket, and an indexable turning insert mounted in the pocket. The pocket opens in a front surface and in a side surface of the basic body, and accommodates two spaces spaced-apart level-wise, a lower space housing the shim plate and delimited by a bottom surface and two side support surfaces, which form an acute angle with each other, one of which is a primary side support surface and the other one a secondary side support surface, and an upper space housing the turning insert. The shim plate includes an upperside and an underside between which a pair of primary and secondary contact surfaces extend, which form an acute angle with each other and are urged against the primary and secondary side support surfaces in the pocket, as well as a pair of inactive surfaces extend in the form of an outer end surface and an outer side limiting surface, which together delimit a supporting corner section of the shim plate.

Abstract: A tool for chip removing machining, including a basic body and a cutting insert detachably connected to the basic body via an interface. The interface includes a first connecting surface formed in the basic body in which a chute is formed that has two side-flank surfaces diverging from a bottom. The interface also includes a second connecting surface formed in the cutting insert in which there are formed a number of male members having converging side-flank surfaces that abut against the side-flank surfaces of the chute, and at least one transverse shoulder surface that abuts against a transverse stop surface in the connecting surface of the basic body.

Abstract: The invention relates to a cutting tool including a basic body and a cutting insert detachably connected to the basic body via an interface, which includes a pair of co-operating connecting surfaces in which engagement means are included, which may be in the form of knobs and seatings. A knob and a co-operating seating have a rotationally symmetrical, conical shape to prevent translation of the cutting insert in the plane of the interface. Another knob ensures that the cutting insert cannot be rotated in relation to the conical knob. Simultaneously, ample bearing surfaces abut against co-operating support surfaces in a connecting surface. In such a way, the cutting insert is fixed in a stable, non-overdetermined position in the basic body. Furthermore, the invention relates to a cutting insert as such.

Abstract: A tool for chip removing machining, including a basic body and a cutting insert detachably connected to the basic body via an interface. The interface includes a first connecting surface formed in the basic body in which a chute is formed that has two side-flank surfaces diverging from a bottom. The interface also includes a second connecting surface formed in the cutting insert in which there are formed a number of male members having converging side-flank surfaces that abut against the side-flank surfaces of the chute, and at least one transverse shoulder surface that abuts against a transverse stop surface in the connecting surface of the basic body.

Abstract: A turning tool including a basic body having an insert seat, an indexable turning insert having a triangular basic shape, and a tightening element fixing the turning insert in the insert seat. The insert includes an upperside and an underside between which three side surfaces extend that are situated in a first imaginary, equilateral triangle and therefore converge in pairs at an angle of 60° toward corners in which cutting edges are included. The turning insert is engaged with the insert seat via an interface that includes elongate and straight, female-like and male-like engagement members, which are in engagement with each other in order to prevent turning of the turning insert. The insert seat includes a supporting surface having a corner section against which an active corner of the turning insert is applied.

Abstract: A turning tool including a basic body having a pocket, a shim plate mounted in the pocket, and an indexable turning insert mounted in the pocket. The pocket opens in a front surface and in a side surface of the basic body, and accommodates two spaces spaced-apart level-wise, a lower space housing the shim plate and delimited by a bottom surface and two side support surfaces, which form an acute angle with each other, one of which is a primary side support surface and the other one a secondary side support surface, and an upper space housing the turning insert. The shim plate includes an upperside and an underside between which a pair of primary and secondary contact surfaces extend, which form an acute angle with each other and are urged against the primary and secondary side support surfaces in the pocket, as well as a pair of inactive surfaces extend in the form of an outer end surface and an outer side limiting surface, which together delimit a supporting corner section of the shim plate.

Abstract: A tool for chip removing machining, including a basic body, and a cutting insert fixed in an insert seat in the basic body by a tightening element, and which, via at least one shoulder surface, is held pressed against a stop surface in the insert seat. An elastically deformable spring is arranged in the insert seat, which provides, by elastic deformation as a result of tightening of the tightening element, the pressing of the shoulder surface against the stop surface.

Abstract: A cutting insert having a front cutting edge and a connecting surface including male- and/or female-like engagement portions, in order to rigidly secure the cutting insert, a geometrically predetermined reference locus serving as a force-application spot for the clamping of the cutting insert. Simultaneously active engagement portions are of only two types—a first, elongate engagement portion, which is located between the front cutting edge and the reference locus, and a second, elongate engagement means, which is oriented at an angle to the first engagement portion and situated at a greater distance from the front cutting edge than the reference locus. In such a way, it is guaranteed that a tightening force always is applied to the cutting insert in a substantially triangular area, which is defined by the free ends of the engagement portions. Furthermore, a tool for chip removing machining, as well as an attachment, e.g., a shim plate, for such tools is provided.

Abstract: The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject.

Abstract: The invention relates to a cutting tool including a basic body and a cutting insert detachably connected to the basic body via an interface, which includes a pair of co-operating connecting surfaces in which engagement means are included, which may be in the form of knobs and seatings. A knob and a co-operating seating have a rotationally symmetrical, conical shape to prevent translation of the cutting insert in the plane of the interface. Another knob ensures that the cutting insert cannot be rotated in relation to the conical knob. Simultaneously, ample bearing surfaces abut against co-operating support surfaces in a connecting surface. In such a way, the cutting insert is fixed in a stable, non-overdetermined position in the basic body. Furthermore, the invention relates to a cutting insert as such.