Patents by Inventor Claudio De Simone

Claudio De Simone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240075585
    Abstract: Monitoring system (12) for a mobile component (3), for example a rotating component, supported by a stationary component (2).
    Type: Application
    Filed: December 17, 2021
    Publication date: March 7, 2024
    Inventors: Alessandro Ruggeri, Daniele Lanzoni, Andrea Turrini, Claudio De Simone, Christian Wurm
  • Publication number: 20240036547
    Abstract: Monitoring system (12) for a mobile component (3), for example a rotating component, supported by a fixed component (2). The monitoring system (12) components: two acoustic sensors (10) which are separate and independent from each other and are positioned in the rotating component (3); two first amplifiers (18) positioned in the rotating component (3); a single contactless communication unit (14) provided with a first transceiver device (15) positioned in the rotating component (3) and a second transceiver device (16) which faces the first transceiver device (15) and is positioned in the stationary component (2); two first connection lines (19), each of which connects a sensor (10) to a first amplifier (18); and a multiplexer (39) having two inputs connected to the two first amplifiers (18) and a single output which is connected to the first transceiver device (15) of the single communication unit (14).
    Type: Application
    Filed: December 17, 2021
    Publication date: February 1, 2024
    Inventors: Daniele Lanzoni, Alessandro Ruggeri, Claudio De Simone, Andrea Turrini, Christian Wurm
  • Publication number: 20240025012
    Abstract: Monitoring system (12) for a mobile component (3), for example a rotating component, supported by a stationary component (2).
    Type: Application
    Filed: December 17, 2021
    Publication date: January 25, 2024
    Inventors: Christian Wurm, Alessandro Ruggeri, Claudio De Simone, Daniele Lanzoni, Andrea Turrini
  • Publication number: 20230113992
    Abstract: The present invention relates to the use of bacterial compositions having an arginine deaminase activity (inhibition of nitric oxide synthase by conversion of L-arginine to L-citrulline) of 1-1,000 ?mol L-citrulline/h/g composition and a sphingomyelinase (ceramide generation) activity of 0.01-1.000 nmoles ceramides/h/g composition in the treatment and/or prophylaxis of airway diseases caused by viruses such as influenza viruses, coronaviruses, as SARS-CoV, MERS-CoV and SARS-CoV-2, avian viruses, respiratory syncytial virus (VRS), rhinoviruses, pneumoviruses, or respiratory failure induced or aggravated by viral infections, angina pectoris, pulmonary heart, respiratory distress, pulmonary edema, neonatal asphyxia, myocardial infarction, heart failure, respiratory failure Pickwick syndrome, pulmonary hypertension, pneumonia or even cystic fibrosis (CF) aggravated by viral infections.
    Type: Application
    Filed: February 2, 2021
    Publication date: April 13, 2023
    Inventor: Claudio DE SIMONE
  • Patent number: 9439953
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 13, 2016
    Assignee: VSL PHARMACUETICALS, INC.
    Inventor: Claudio De Simone
  • Publication number: 20150351415
    Abstract: A mixture of at least 6 species of lactic acid bacteria and/or Bifidobacteria is disclosed for use in bakery and medical field. The preferred mixture comprises Streptococcus thermophilus, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus delbrueckii subsp. bulgaricus. Said mixture is useful for a sourdough, a leavening composition. Baked goods and other food products obtained therefrom are disclosed. These goods have low or no gluten content and are suitable for the integration of the diet of a subject suffering from celiac disease, for decreasing the risk of allergies due to wheat flour albumins and globulins, for the treatment of schizophrenic symptoms, in the preparation of products for enteric diet.
    Type: Application
    Filed: April 14, 2015
    Publication date: December 10, 2015
    Inventors: Claudio DE SIMONE, Franco PIROVANO
  • Publication number: 20140140971
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: VSL PHARMACEUTICALS INC.
    Inventor: Claudio DE SIMONE
  • Patent number: 8697051
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 15, 2014
    Assignee: VSL Pharmaceuticals Inc.
    Inventor: Claudio De Simone
  • Publication number: 20110217759
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7?-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Application
    Filed: May 20, 2011
    Publication date: September 8, 2011
    Inventor: Claudio DE SIMONE
  • Patent number: 7959911
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7?-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: June 14, 2011
    Assignee: VSL Pharmaceuticals Inc.
    Inventor: Claudio De Simone
  • Patent number: 7628981
    Abstract: Describes a new strain of Streptococcus thermophilus ssp. salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zeilkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: December 8, 2009
    Assignee: VSL Pharamaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20080131556
    Abstract: A mixture of at least 6 species of lactic acid bacteria and/or Bifidobacteria is disclosed for use in bakery and medical field. The preferred mixture comprises Streptococcus thermophilus, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus delbrueckii subsp. bulgaricus. Said mixture is useful for a sourdough, a leavening composition. Baked goods and other food products obtained therefrom are disclosed. These goods have low or no gluten content and are suitable for the integration of the diet of a subject suffering from celiac disease, for decreasing the risk of allergies due to wheat flour albumins and globulins, for the treatment of schizophrenic symptoms, in the preparation of products for enteric diet.
    Type: Application
    Filed: March 7, 2006
    Publication date: June 5, 2008
    Applicant: VSL PHARMACEUTICALS, INC.
    Inventors: Claudio De Simone, Franco Pirovano
  • Patent number: 7323317
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: January 29, 2008
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20070253934
    Abstract: Describes a new strain of Streptococcus thermophilus ssp. salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
    Type: Application
    Filed: November 27, 2006
    Publication date: November 1, 2007
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20070218132
    Abstract: The present invention relates to a pH test glove bearing a reporter substance indicating the possible presence of vaginal affection. such as infections, in particular bacterial vaginosis, or vaginitis. This glove is easy to use, accurate and safe for the woman using it.
    Type: Application
    Filed: December 23, 2004
    Publication date: September 20, 2007
    Applicants: ACTIAL FARMACEUTICA LDA., VSL PHARMACEUTICALS, INC.
    Inventor: Claudio De Simone
  • Publication number: 20070154974
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: RE39876
    Abstract: Enteral compositions containing Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum, each at a concentration equal to or greater than 1×1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff. The present invention relates to a kit comprising two containers, one containing a foodstuff and the other containing the enteral composition consisting of Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: October 9, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: RE39892
    Abstract: Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri. A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis. A method of treating vaginosis and vaginitis based on administration of said pharmaceutical composition.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: October 23, 2007
    Inventor: Claudio De Simone
  • Patent number: RE40457
    Abstract: Enteral compositions containing a mixture of live lactic bacteria consisting of Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium infantis, each at a concentration equal to or greater than 1×1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: August 12, 2008
    Assignee: VSL Pharmaceuticals, Inc.
    Inventors: Renata Maria Anna Cavaliere ved. Vesely, Claudio De Simone
  • Patent number: RE41276
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7?-dehydroxylase activity of less than 50%, and (b) bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: April 27, 2010
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone