Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: A side blow molding apparatus of (100) includes upper guide rails (106) and lower guide rails (108). The apparatus (100) includes a side blow device (110) having a blow pin assembly (112) and an inner support assembly (114). The blow pin assembly (112) includes a blow pin driver (116) formed as a cylinder (118). The blow pin assembly (112) also includes a blow pin (122) connected to a shuttle system (124) which, in turn, is connected to the cylinder (118). The shuttle system (124) operates so as to move the blow pin (122) in a linear manner. The inner support assembly (114) includes an inner support driver (138) connected to an extender (144). The inner support driver (138) extends and retracts the extender (144) for raising and lowering the inner support (142). The blow pin (122) is positioned on the shuttle system (124) so that the pin (122) can be shuttled in and out of a parison during the blow molding process.

Abstract: Apparatus and methods described herein provide for the management of noise associated with a duct. A sound-dampening apparatus is provided consisting of a duct through which a fluid flows, such as an air duct. A flexuous cord is helically wound around the inner or outer surface of the duct at a pitch corresponding to a selected acoustical frequency range associated with the fluid flow through the duct.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: The present invention provides a laser-sensitive coating composition comprising titanium dioxide in the anatase form or polymeric particles comprising a polymeric matrix comprising one or more water-insoluble polymers and titanium dioxide in the anatase form encapsulated in the polymeric matrix, and a polymeric binder. The present invention also provides a process for the preparation of the compositions, processes for preparing substrates coated with the coating compositions, substrates coated with the compositions, processes for marking the substrates coated with the compositions, and marked substrates obtainable by the latter processes.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: An air intake for a supersonic air-breathing flight vehicle introduces or injects fluid in order to create predetermined regions of separated flow and an attendant fluid shear layer. This shear layer forms an aerodynamic boundary for the capture flow with a profile determined and optimised by appropriate injection of fluid. The aerodynamic boundary so generated replaces mechanically moveable solid surfaces used to vary the geometry of prior-art intakes. Use of an introduced or injected fluid can provide an advantage of a variable geometry, but with reduced weight and reduced mechanical complexity. In some embodiments, the injection of fluid has the effect of re-energising any ingested boundary layer, thus obviating the conventional requirement for a bleed system to provide boundary layer control.

Abstract: Apparatus and methods described herein provide for the management of noise associated with a duct. A sound-dampening apparatus is provided consisting of a duct through which a fluid flows, such as an air duct. A flexuous cord is helically wound around the inner or outer surface of the duct at a pitch corresponding to a selected acoustical frequency range associated with the fluid flow through the duct.

Abstract: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

Abstract: The present invention provides a tool that can be used to load catalyst into a chemical reactor. In a preferred embodiment, the tool may also be used to measure the outage in the reactor tube. Also in a preferred embodiment, the tool provides a way to prevent dust from accumulating on the upper tube sheet of the reactor while loading catalyst into the reactor tubes.

Abstract: A device and method for loading pellets into chemical reactor tubes.

Abstract: A method of preparing a polymeric aryl sulfonamide is described which consists of reacting aryl sulfonyl with a polymeric amine in the presence of an acid acceptor. Also, another method of preparing a polymeric aryl sulfonamide is disclosed and consists of: reacting an aryl sulfonyl with a polymeric diamine in the presence of an acid acceptor to result in a linear oligomeric molecule; and reacting the linear oligomeric molecule with a monoamine or an aryl monosulfonyl in the presence of an acid acceptor. The use of polymeric aryl sulfonamides as pigment dipersants and wetting agents is also disclosed.

Abstract: A device and method for measuring the back pressure in chemical reactor tubes includes many automated features. Inflatable tube seals may be automatically inflated. The device may measure several tubes at once. It may transmit data electronically to a remote computer for analysis and graphic display.

Abstract: Comprising an engine and intelligent agents, the invented system monitors a data network for important events selected by the user and upon detection puts the information into action. Examples of actions that can be initiated include: updating ODBC compliant databases, sending E-mail (with file attachments) to a customer, partner or employee, merging data with and printing RTF documents, invoking VBScript or Jscript, running a program, executing SQL statements or stored procedures. The invented system incorporates a data monitor, process scheduler, and an event logging system. It establishes a snapshot of a data network, without replication, and compares this snapshot with the data viewed subsequently to determine if any data in the table being monitored has been changed, deleted, or added.

Abstract: A method of preparing a polymeric aryl sulfonamide is described which consists of reacting aryl sulfonyl with a polymeric amine in the presence of an acid acceptor. Also, another method of preparing a polymeric aryl sulfonamide is disclosed and consists of: reacting an aryl sulfonyl with a polymeric diamine in the presence of an acid acceptor to result in a linear oligomeric molecule; and reacting the linear oligomeric molecule with a monoamine or an aryl monosulfonyl in the presence of an acid acceptor. The use of polymeric aryl sulfonamides as pigment dipersants and wetting agents is also disclosed.

Abstract: An environmental monitoring system for a hazardous work area, such as a nuclear power plant, which monitors the radiation exposure of personnel working in the nuclear power plant and overlays a visual representation of the exposure data onto a video display of the location the personnel are working in. The apparatus includes a video source, such as a plurality of PTZ cameras, for providing video image signals of the work area. In the preferred embodiment, individual radiation exposure sensors provide signals representative of the radiation received by each worker in the work area. A computer, outside of the work area, is connected to the sensors for converting the sensor signals to a visual video representation of the sensor measurements. A gen/lock overlay unit is connected to the computer for combining the video image signals and the visual video representation of the sensor measurements wherein the visual video representations are overlaid onto the video images of the work area.

Abstract: An on-line financing application service includes a master financing application template and associated tools for use by funding sources in creating organizational financing application templates, and therefrom financing program offerings. In various embodiments, the on-line financing application service further includes facilities for the funding sources in defining rate structures and the processes for selecting the rate structures for the various program offerings. In various embodiments, the on-line financing application service further includes facilities for the funding sources in defining application approval/disposition processes for automatically approving, rejecting or referring financing applications submitted for consideration under alternate rate sheets for quotes or under alternate program offerings of the same or different funding sources.