Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: An apparatus for sterilizing objects includes a chamber with a heated base in thermal communication with an electric heating element; a forced air flow device arranged to direct air into the chamber; an electrical power supply circuit; a thermomechanical control in series with the electric heating element and arranged to detect a temperature of the heated base; and a thermally sensitive switch in series with the forced air flow device and arranged to detect a temperature of the heated base. The apparatus is configured to operate in a sterilization mode and in a drying mode.

Abstract: A liquid heating appliance including a reservoir including a first and second chambers and a heating arrangement is provided. A mode valve is arranged to selectively allow liquid to flow between the first and second chambers. The appliance operates in a first mode in which the mode valve is closed and only liquid in the first chamber is heated and a second mode in which the mode valve is open and liquid in the first and second chambers is heated. A dispense outlet is moveable between a dispensing position and a non-dispensing position. The dispense outlet is mechanically coupled to the mode valve such that when the dispense outlet is moved into the dispense position, the mechanical coupling closes the mode valve and when the dispense outlet is moved into the non-dispensing position, the mechanical coupling opens the valve.

Abstract: The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.

Abstract: A method of bonding includes providing a thermoplastic substrate having a surface with a surface energy value of less than a 48 miliJoules per meter squared. The surface is exposed to particulate formed in a combustion flame from a precursor. The particulate forms an adherent layer of metal oxide on the surface. An adhesive is applied to the adherent layer. A second substance is placed in in simultaneous contact with the adhesive to bond the thermoplastic. A laminate is provided that includes a thermoplastic substrate having a surface. An adherent layer of metal oxide is on a surface of the thermoplastic substrate. An adhesive is attached to the adherent layer. A second substance is in simultaneous contact with the adhesive.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: An apparatus for sterilizing objects includes a chamber with a heated base in thermal communication with an electric heating element ; a forced air flow device arranged to direct air into the chamber; an electrical power supply circuit; a thermomechanical control in series with the electric heating element and arranged to detect a temperature of the heated base; and a thermally sensitive switch in series with the forced air flow device and arranged to detect a temperature of the heated base. The apparatus is configured to operate in a sterilization mode and in a drying mode.

Abstract: A thermally sensitive control for controlling a power supply circuit to a heater in a liquid heating appliance is provided. The control includes a cordless connector part arranged to mate with a base connector part, first and second moveable electrical contacts mounted on first and second moveable members, and first and second thermally sensitive actuators. The control further includes a latch arm extending across the control between the moveable members, the latch arm including a first latch for the first moveable member and a second latch for the second moveable member, and a release member including a release part and a plunger, wherein the release member is resiliently biased to bring the release part into contact with the latch arm but the resilient bias is overcome when the plunger bears against a surface of the base connector part.

Abstract: The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: This disclosure includes devices, systems, apparatuses, and implementations associated with a wall-mounted beverage dispensing system. The beverage dispensing system is configured to fit between standard space between studs. In some implementations, the studs may provide the sole support for the beverage dispensing system. The beverage dispensing system may include a filter that is accessible for replacement without the use for tools.

Abstract: The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: Processing cacao to produce a product containing all the constituents of raw cacao nibs is disclosed. The process involves: (i) a shortened period of fermentation of the cacao beans between five hours and forty eight hours. (ii) a prolonged period of drying to condition the beans so that the shells are removable by air winnowing. (iii) a two stage grinding process in which the raw (unroasted) nibs are ground, without forming or at least separating into a liquor, to a mesh size of 60 ?m.

Abstract: The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: An apparatus for dispensing a predetermined volume of a warm liquid includes a heater, a pump and a temperature sensor sensitive to the temperature of the liquid upstream of the heater. A controller is arranged to receive upstream temperature data from the temperature sensor, calculate the amount of energy required to reach a desired final temperature, energize the heater for a calculated period of ON time, and dispense liquid for a calculated period of time that is at least partly contemporaneous with the calculated period of ON time. After the heater has been de-energized, the dispensed liquid removes residual heat so that the average temperature after dispensing the predetermined volume is the desired final temperature.