Abstract: The present disclosure is directed towards a clamping assembly for compressing a plurality of optical plates of a high pressure cavitation system. The clamping assembly may include a mounting frame and a housing coupled to the mounting frame. The clamping assembly may further include a holder distal the housing, the holder having the plurality of optical plates disposed therein. The clamping assembly further including a controllable clamping mechanism operably coupled to a top of the housing, the controllable clamping mechanism applying an axial force to the plurality of optical plate.

Abstract: Inflatable members for incorporation into a fascine are linked together at their ends by chains or other such flexible tension members, the tension in which is such as to cause at least local compression and flattening of the inflatable members where they are in contact with adjacent members. The forces so generated between adjacent members can prevent their tendency to rotate under the action of traffic crossing the fascine.

Abstract: Methods of screening and designing compounds as inhibitors of glutamine synthetase are provided herein. Compounds, e.g., serine protease inhibitors, and compositions comprising the same, that are useful for the treatment, prevention, and/or amelioration of bacterial infections, including Mycobacterium tuberculosis, are also provided.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: A transfer system for bundle transfer, in which the amount of route information and the number of times advertisement is performed are reduced, and maintenance and management are made to be highly efficient to implement improved transfer quality. A path setting section specifies a path between nodes for a receiving side as a bundled link which can have a plurality of paths tied up. A transmission-side route-information advertisement section advertises route information in a network when recognizing that the path has been established. A path recognition section recognizes the path and sets the path as a bundled link. A receiving-side route-information advertisement section advertises the route information in the network when recognizing that the path has been established.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

Abstract: The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II): are useful in providing compounds to assay for such therapeutically useful compounds.

Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Abstract: Coolant systems, for power sources (e.g. internal combustion engines, fuel cells, and nuclear reactors) or microprocessors for example, are beneficially operated with coolant in a nucleate boiling state, but transitions to damaging film boiling are then possible. The disclosed coolant system includes a sensor, such as a thermocouple or thermistor, that provides a signal representative of fluctuations in the temperature at a heated surface. The signal also includes at least one parameter. A controller processes the signal to determine changes in the parameter of the signal and/or to determine the state of the coolant and can responsively change the coolant flow to avoid undesirable coolant states. For example, coolant flow can be changed by changing the output of a coolant pump. The controller can change coolant flow automatically, or a signal can be provided to an operator that an undesirable coolant state change is imminent or has occurred, thereby allowing operator intervention.

Abstract: Disclosed is a modular bridge, typically for temporary use to enable persons to pass between upper floors of adjacent buildings during fire fighting or disaster relief operations, which can be rapidly assembled and deployed within a confined space and entirely from the “home” side of the gap to be crossed. It comprises a plurality of man-portable box section bridge modules adapted to be connected together end to end and projected in cantilever fashion from one side of the gap to the other. The assembly of modules is supported in and guided through a launch frame, with modules being added to the rear of the assembly and pushed through the frame until the gap is spanned. Removable lever arms of the frame are used to counterbalance the weight of the projected bridge modules during the course of deployment.

Abstract: The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

Abstract: A document feeder comprises an input hopper (1) into which batches of documents with interleaved separators (24, 25) are loaded in use, each separator carrying data related to the associated batch. A feed system (9, 10) withdraws documents and separators singly from the input hopper. A sensing system (7) obtains information about the documents and separators. The sensing system includes a data sensor (7) located so as to read separator data while the separator (24, 25) is in the input hopper (1).