Abstract: The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: Processing cacao to produce a product containing all the constituents of raw cacao nibs is disclosed. The process involves: (i) a shortened period of fermentation of the cacao beans between five hours and forty eight hours. (ii) a prolonged period of drying to condition the beans so that the shells are removable by air winnowing. (iii) a two stage grinding process in which the raw (unroasted) nibs are ground, without forming or at least separating into a liquor, to a mesh size of 60 ?m.

Abstract: The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: An apparatus for dispensing a predetermined volume of a warm liquid includes a heater, a pump and a temperature sensor sensitive to the temperature of the liquid upstream of the heater. A controller is arranged to receive upstream temperature data from the temperature sensor, calculate the amount of energy required to reach a desired final temperature, energize the heater for a calculated period of ON time, and dispense liquid for a calculated period of time that is at least partly contemporaneous with the calculated period of ON time. After the heater has been de-energized, the dispensed liquid removes residual heat so that the average temperature after dispensing the predetermined volume is the desired final temperature.

Abstract: A way to analyze/visualize the options available to safely and effectively drill an oil or gas well through a pore pressure/fracture gradient (drilling) window is presented. This method has not been previously recognized or developed and switches the focus from the traditional view using a pressure gradient (mud weight or density) to a view using pressure relative to the pressure that would be supplied by the mud weight that is in the well at a static condition (the baseline). This analysis/visualization has many advantages. It is easy to integrate Managed Pressure Drilling Operations, Horizontal wells, information from logging while drilling tools and in a real-time environment allows for the impact of operational fluctuations to be readily assessed and modeled. It is also envisaged that this analysis/visualization will enable regulatory authorities to better assess the safety of well operations reinforcing their ability to influence safe and effective drilling.

Abstract: The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.

Abstract: A light bar for illuminating a surface that is substantially perpendicular to the light bar includes an elongated housing extending along an edge of the surface to be illuminated. The housing has a wall adjacent the surface to be illuminated, and at least portions of that wall are transparent. A series of light emitting diodes (LEDs) are mounted within the housing and spaced along the length of the housing for illuminating the surface, and a connector couples the LEDs to an electrical power source for energizing the LEDs to produce light that illuminates the surface.

Abstract: A vapor hood for a proppant blending system, with a proppant entrance port to receive proppant, the proppant entrance port having a one way valve to allow the flow of proppant but prevent the backflow of vapor when the proppant is not entering the vapor hood.

Abstract: A flow heater is provided including a heating element, a channel heated by said heating element for heating liquid flowing therethrough, and temperature sensing means in thermal communication with both the heating element and the channel so as to be sensitive to the temperature of the liquid in the channel and the temperature of the heating element.

Abstract: There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.

Abstract: There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.

Abstract: An apparatus for dispensing a predetermined volume of a warm liquid includes a heater, a pump and a temperature sensor sensitive to the temperature of the liquid upstream of the heater. A controller is arranged to receive upstream temperature data from the temperature sensor, calculate the amount of energy required to reach a desired final temperature, energize the heater for a calculated period of ON time, and dispense liquid for a calculated period of time that is at least partly contemporaneous with the calculated period of ON time. After the heater has been de-energized, the dispensed liquid removes residual heat so that the average temperature after dispensing the predetermined volume is the desired final temperature.

Abstract: A vapor hood for a proppant blending system, with a proppant entrance port to receive proppant, the proppant entrance port having a one way valve to allow the flow of proppant but prevent the backflow of vapor when the proppant is not entering the vapor hood.

Abstract: A wearable poncho for allowing a user exposed to an extreme temperature, whether extreme heat or extreme cold, to selectably cover their body or a body part so as to allow the user to obtain protection from said extreme temperature. The wearable poncho comprises a modified poncho base having a watertight outer nylon layer, an insulation layer disposed inside said nylon layer, and a gel layer disposed inside said insulation layer, wherein the poncho base includes a receiving opening adapted to receive a head, a head covering hood disposed near said receiving opening, and an elongated sealable closure. This structure allows the wearable poncho to provide portable protection from not just precipitation and cold, but from extreme cold and extreme heat, without having to be preheated or pre-cooled by some external means.

Abstract: A flow heater is provided including a heating element, a channel heated by said heating element for heating liquid flowing therethrough, and temperature sensing means in thermal communication with both the heating element and the channel so as to be sensitive to the temperature of the liquid in the channel and the temperature of the heating element.

Abstract: An method and corresponding apparatus for detecting a change in an aspect of performance of a data processing system and for adjusting operation of a system so as to counter the detected change. The method generating a value representative of an aspect of performance of a data processing system relative to operation of the system in a first sub-period of each in a plurality of first time periods; in which each first sub-period is located with the same degree of offset within the respective first time period. The generated value may represent a norm or typical value for the aspect of behaviour in the sub-period.

Abstract: A light bar for illuminating a surface that is substantially perpendicular to the light bar includes an elongated housing extending along an edge of the surface to be illuminated. The housing has a wall adjacent the surface to be illuminated, and at least portions of that wall are transparent. A series of light emitting diodes (LEDs) are mounted within the housing and spaced along the length of the housing for illuminating the surface, and a connector couples the LEDs to an electrical power source for energizing the LEDs to produce light that illuminates the surface.

Abstract: A medium, system, and method are disclosed for implementing an in-memory inode cache. The cache stores inodes that include respective file metadata. The system includes a replacement module that prioritizes the inodes for replacement according to retention priorities for the inodes. The system also includes a prioritization module that is configured to increase the retention priority of a given inode in the cache in response to detecting a cache hit on the given inode and that the given inode meets one or more longevity criteria.

Abstract: A medium, system, and method are disclosed for implementing an in-memory inode cache. The cache stores inodes that include respective file metadata. The system includes a replacement module that prioritizes the inodes for replacement according to retention priorities for the inodes. The system also includes a prioritization module that is configured to respond to a file close operation by determining whether the file is unlikely to be reopened. If so, the prioritization module responds by decreasing the respective retention priority of one of the inodes, where the one inode stores file metadata for the closed file.

Abstract: The present disclosure provides an apparatus and method for removing particulates from a gas stream. The apparatus includes a ceramic filter, at least one electrode, and at least one conductor. The electrode is located at an end of the filter and produces an atmospheric glow discharge in order to oxidize carbon deposits trapped in the filter. The conductor extends at least partially into the filter and acts as a counter electrode. Through various arrangements of the electrodes and conductors, the present disclosure provides closer connection between the trapped carbon deposits and the electrodes. This improves the regeneration of the filter without increasing the size and/or weight of the apparatus.