Patents by Inventor Curtis C. Harris

Curtis C. Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pot1 alternative splicing variants
    Publication number: 20090054361
    Abstract: The present invention provides methods an compositions for diagnosis and treatment of carcinomas with aberrant expression patterns of POT 1. The invention also provides methods of identifying compounds that may modulate the cellular expression of POT 1. The invention further provides methods for treating subjects suffering from or at risk of developing a colorectal carcinoma.
    Type: Application
    Filed: October 19, 2005
    Publication date: February 26, 2009
    Applicant: Government of the US, as represented by the Secretary Dept of Health & Human Services
    Inventors: Qin Yang, Curtis C. Harris
  • Microrna-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer
    Publication number: 20080306017
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provide methods of identifying anti-lung cancer agents.
    Type: Application
    Filed: January 3, 2007
    Publication date: December 11, 2008
    Applicants: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Nozomu Yanaihara, Curtis C. Harris
  • Method of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7438892
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: The United States of Americas as represented by the Secretary of the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jill D. Coursen, Qimin Zhan
  • Tumor suppressor gene, p28ING5
    Patent number: 7432349
    Abstract: This disclosure provides a novel tumor suppressor, referred to as p28ING5, nucleic acid molecules encoding this protein, and methods of making and using these molecules. Also provided are methods of ameliorating, treating, detecting, prognosing, and diagnosing diseases and conditions associated with abnormal p28ING5 expression, such as neoplasia. Kits are also provided.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: October 7, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Remy Pedeux, Makoto Nagashima, Masayuki Shiseki
  • Tumor supressor gene p33ING2
    Patent number: 7431926
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: October 7, 2008
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • SOCS-1 Gene Methylation in Cancer
    Publication number: 20080213782
    Abstract: Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods.
    Type: Application
    Filed: February 22, 2008
    Publication date: September 4, 2008
    Inventors: James. G. Herman, Hirohide Yoshikawa, Curtis C. Harris
  • TUMOR SUPPRESSOR GENE, P47ING3
    Publication number: 20080171854
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Application
    Filed: December 21, 2007
    Publication date: July 17, 2008
    Applicant: The Govt. of the USA as represented by the Secretary of the Dep. of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • SOCS-1 GENE METHYLATION IN CANCER
    Publication number: 20080076117
    Abstract: Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods.
    Type: Application
    Filed: April 15, 2002
    Publication date: March 27, 2008
    Inventors: James G. Herman, Hirohide Yoshikawa, Curtis C. Harris
  • SOCS-1 gene methylation in cancer
    Patent number: 7348139
    Abstract: Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: March 25, 2008
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: James G. Herman, Hirohide Yoshikawa, Curtis C. Harris
  • Screening assays for compounds that cause apoptosis
    Patent number: 7338807
    Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: March 4, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Xin Wei Wang, Jan H. J. Hoeijmakers
  • Tumor suppressor gene, p47Ing3
    Patent number: 7335749
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: February 26, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • Methods of identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 7125850
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: October 24, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Sevices
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Methods for identifying inhibitors of GADD45 polypeptide activity and inhibitors of such activity
    Patent number: 7005419
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: February 28, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Tumor supressor gene p33ING2
    Publication number: 20040235111
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 25, 2004
    Applicant: The U.S.A., as represented by the Secretary of the Dept. of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • Tumor suppressor gene p33ING2
    Patent number: 6790948
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: September 14, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Makoto Nagashima
  • Screening assays for compounds that cause apoptosis
    Publication number: 20040115747
    Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
    Type: Application
    Filed: August 4, 2003
    Publication date: June 17, 2004
    Applicant: The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
    Inventors: Curtis C. Harris, Xin Wei Wang, Jan H.J. Hoeijmakers
  • Tumor suppressor gene, p47Ing3
    Publication number: 20040058379
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
    Type: Application
    Filed: August 8, 2002
    Publication date: March 25, 2004
    Inventors: Curtis C. Harris, Makoto Natashima
  • Methods for identifying inhibitors of GADD45 polypeptide activity, and inhibitors of such activity
    Patent number: 6613318
    Abstract: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: September 2, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin Wei Wang, Curtis C. Harris, Albert J. Fornace, Jr., Jill D. Coursen, Qimin Zhan
  • Screening assays for compounds that cause apoptosis and related compounds
    Patent number: 6613883
    Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: September 2, 2003
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Curtis C. Harris, Xin Wei Wang, Jan H. J. Hoeijmakers
  • Screening assays for compounds that cause apoptosis
    Patent number: 6602979
    Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: August 5, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Xin Wei Wang, Jan H. J. Hoeijmakers