Abstract: Using the cobblestone area (CA) formation inhibitory activity of human leukemic stem cell-like cells as an indicator, a fraction having the activity has been extracted from the fat-soluble fraction of Porifera, then, a compound having the activity has been isolated and purified from the aforementioned fraction, and then, the structure thereof has been determined, so that a Stelliferin compound comprising a novel compound has been identified. Moreover, it has been found that the isolated and purified Stelliferin compound significantly suppresses the niche formation of leukemic stem cell-like cells derived from human chronic myelogenous leukemia (CML) having resistance to existing antitumor agents and enhances the effects of antitumor agents on the cells.

Abstract: A semiconductor device includes: a semiconductor base body where a second semiconductor layer is stacked on a first semiconductor layer, a trench is formed on a surface of the second semiconductor layer, and a third semiconductor layer which is formed of an epitaxial layer is formed in the inside of the trench; a first electrode; an interlayer insulation film which has a predetermined opening; and a second electrode, wherein metal is filled in the opening, the opening is disposed at a position avoiding a center portion of the third semiconductor layer, the second electrode is connected to the third semiconductor layer through the metal, and a surface of the center portion of the third semiconductor layer is covered by the interlayer insulation film.

Abstract: A power semiconductor device according to the present invention has a super junction structure, and includes a low-resistance semiconductor layer, an n?-type column region, p?-type column regions, a base region, trenches, gate insulation films, gate electrodes, source regions, interlayer insulation films, contact holes, metal plugs, p+-type diffusion regions, a source electrode and a gate pad electrode. An active element part includes an n?-type column region between a predetermined p?-type column region disposed closest to a gate pad part and a predetermined n?-type column region disposed closest to the gate pad part among the n?-type column regions which are in contact with the trenches. The present invention provides a power semiconductor device which can satisfy a demand for reduction in cost and downsizing of electronic equipment, can lower ON resistance while maintaining a high withstand voltage, and can possess a large breakdown resistance.

Abstract: An ion filter is used for a gas detector including a gas electron multiplier. The ion filter includes: an insulating substrate; a first patterned conductive layer on one main surface of the insulating substrate; and a second patterned conductive layer on another main surface of the insulating substrate. The ion filter has a plurality of through-holes formed along a thickness direction of the insulating substrate on which the first patterned conductive layer and the second patterned conductive layer are formed. The one main surface of the insulating substrate is disposed on an upstream side in a movement direction of electrons in the gas detector. The other main surface of the insulating substrate is disposed on a downstream side in the movement direction of the electrons in the gas detector. The first patterned conductive layer has a line width thicker than a line width of the second patterned conductive layer.

Abstract: A power semiconductor device of the present invention includes: a semiconductor base body which has a super junction structure formed of a plurality of first conductive-type columnar regions and a plurality of second conductive-type columnar regions; a plurality of trenches; gate insulation films; gate electrodes; an interlayer insulation film; contact holes formed such that two or more contact holes are formed between two trenches disposed adjacently to each other; metal plugs formed by filling the inside of the contact holes with metal; and an electrode, wherein a first conductive-type high concentration diffusion region is formed only between the trench and the metal plug disposed closest to the trench between each two trenches disposed adjacently to each other. According to the power semiconductor device of the present invention, it is possible to provide a power semiconductor device which satisfies a demand for reduction in cost and downsizing of electronic equipment, and has a large breakdown strength.

Abstract: An ion filter used for an electron multiplier includes an insulating substrate; a first conductive layer formed on one main surface of the substrate; and a second conductive layer formed on another main surface of the substrate. The ion filter has a plurality of through-holes formed along a thickness direction of the substrate. The one main surface of the substrate is disposed at a downstream side in a moving direction of electrons in a chamber of the electron multiplier and the other main surface of the substrate is disposed at an upstream side in the moving direction of electrons in the chamber of the electron multiplier. A first thickness of the first conductive layer formed on the one main surface of the substrate is thicker than a second thickness of the second conductive layer on the other main surface of the substrate.

Abstract: A regenerative current detection circuit includes a first power MOS transistor that is configured as a current mirror to a second power MOS transistor connected to drive a motor winding, a first feedback amplifier that compares a first regenerative current that flows in the first power MOS transistor with a second regenerative current that flows in the second power MOS transistor and outputs a comparison result, the first regenerative current being obtained by multiplying the second regenerative current by a current mirror ratio, and a current detection circuit that outputs a detection current based on the comparison result.

Abstract: An image forming apparatus includes an image forming device, a detector and a holding body. The image forming device is configured to perform an image formation to a sheet. The detector is configured to detect a position of a first image formed on a first surface of the sheet through the image formation of the image forming device. The holding body is configured to move while holding the sheet, by performing one of a rotation in a radial direction about a support shaft attached thereto in a direction perpendicular to an axial direction thereof and a lateral shift in a width direction of the sheet, operable to correct the position of the sheet based on a detection result obtained by the detector.

Abstract: An image formation apparatus includes a toner bottle, a sub hopper configured to temporarily store toner supplied from the toner bottle, a development apparatus configured to receive supply of the toner from the sub hopper, a first detector configured to detect a remaining amount of toner in the toner bottle, a second detector configured to detect an empty space for toner in the sub hopper, and a controller configured to have the toner supplied from the toner bottle to the sub hopper each time the empty space in the sub hopper exceeds a threshold value Th1. When the remaining amount of toner in the toner bottle is smaller than a threshold value ThA, the controller lowers the threshold value Th1 to a threshold value Th2.

Abstract: An ion filter used for an electron multiplier includes an insulating substrate; a first conductive layer formed on one main surface of the substrate; and a second conductive layer formed on another main surface of the substrate. The ion filter has a plurality of through-holes formed along a thickness direction of the substrate. The one main surface of the substrate is disposed at a downstream side in a moving direction of electrons in a chamber of the electron multiplier and the other main surface of the substrate is disposed at an upstream side in the moving direction of electrons in the chamber of the electron multiplier. A first thickness of the first conductive layer formed on the one main surface of the substrate is thicker than a second thickness of the second conductive layer on the other main surface of the substrate.

Abstract: An image formation apparatus includes a toner bottle, a sub hopper configured to temporarily store toner supplied from the toner bottle, a development apparatus configured to receive supply of the toner from the sub hopper, a first detector configured to detect a remaining amount of toner in the toner bottle, a second detector configured to detect an empty space for toner in the sub hopper, and a controller configured to have the toner supplied from the toner bottle to the sub hopper each time the empty space in the sub hopper exceeds a threshold value Th1. When the remaining amount of toner in the toner bottle is smaller than a threshold value ThA, the controller lowers the threshold value Th1 to a threshold value Th2.

Abstract: An image forming apparatus including an image forming unit configured to form an image on a recording medium; an edge detecting unit configured to detect edge positions at a plurality of portions along each side of the recording medium being conveyed; a shape detecting unit configured to detect a shape of the recording medium, based on an edge detection result obtained by the edge detecting unit; and an image correcting unit configured to correct the image to be formed on the recording medium, based on a change in the shape of the recording medium before and after image forming, the change being detected by the shape detecting unit.

Abstract: The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked ?-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.

Abstract: An image forming apparatus including an image forming unit configured to form an image on a recording medium; an edge detecting unit configured to detect edge positions at a plurality of portions along each side of the recording medium being conveyed; a shape detecting unit configured to detect a shape of the recording medium, based on an edge detection result obtained by the edge detecting unit; and an image correcting unit configured to correct the image to be formed on the recording medium, based on a change in the shape of the recording medium before and after image forming, the change being detected by the shape detecting unit.

Abstract: Techniques capable of improving the yield of IGBTs capable of reducing steady loss, turn-off time, and turn-off loss are provided. Upon formation of openings in an interlayer insulting film formed on a main surface of a substrate, etching of a laminated insulating film of a PSG film and an SOG film and a silicon oxide film is once stopped at a silicon nitride film. Then, the silicon nitride film and the silicon oxide film are sequentially etched to form the openings. As a result, the openings are prevented from penetrating through an n-type source layer and a p+-type emitter layer having a thickness of 20 to 100 nm and reaching the substrate.

Abstract: The invention provides a solid golf ball having a core and a cover. The core is formed of a rubber composition containing a base rubber, a co-crosslinking agent, a crosslinking initiator and a metal oxide. The base rubber contains polybutadiene, a styrene-butadiene rubber and, optionally, an isoprene rubber. The co-crosslinking agent is methacrylic acid, and the rubber composition includes a specific waste material in the form of a powder. The core deflection and the cover material are optimized. Utilizing a waste material in a solid golf ball conserves resources and thus is beneficial to the global environment. Even during prolonged use, the golf ball maintains its basic performance attributes (feel, flight, durability) at a high level.

Abstract: The invention provides a solid golf ball having a core and a cover. The core is formed of a rubber composition containing a base rubber, a co-crosslinking agent, a crosslinking initiator and a metal oxide. The co-crosslinking agent is methacrylic acid, and the rubber composition includes a specific waste material in the form of a powder. The core deflection and the cover material are optimized. Utilizing a waste material in a solid golf ball conserves resources and thus is beneficial to the global environment. Even during prolonged use, the golf ball maintains its basic performance attributes (feel, flight, durability) at a high level.

Abstract: The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked ?-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.

Abstract: A multi-piece solid golf ball composed of a solid core having an inner core layer and an outer core layer encased by a cover including at least an inner cover layer and an outer cover layer. The inner core layer has a JIS-C cross-sectional hardness of from 60 to 83 at any single point on a cross-section, and has a cross-sectional hardness difference between any two points on the cross-section of within ±5. The ball has specific relationships between the hardness of the inner core layer 1 mm inside a boundary between the inner core layer and the outer core layer, the hardness of the outer core layer 1 mm outside the boundary, and the surface hardness of the outer core layer. And, the outer cover layer has the specific thickness and Shore D hardness, which is higher than that of the inner cover layer.

Abstract: A multi-piece solid golf ball composed of a solid core having an inner core layer and an outer core layer encased by a cover including at least an inner cover layer and an outer cover layer. The inner core layer has a JIS-C cross-sectional hardness of from 60 to 83 at any single point on a cross-section, and has a cross-sectional hardness difference between any two points on the cross-section of within ±5. The ball has specific relationships between the hardness of the inner core layer 1 mm inside a boundary between the inner core layer and the outer core layer, the hardness of the outer core layer 1 mm outside the boundary, and the surface hardness of the outer core layer. And, the outer cover layer has the specific Shore D hardness, which is lower than that of the inner cover layer.