Abstract: The invention involves a device and method for acquiring bone marrow aspirate. The system includes an elongated cannulated fastener having a threaded end for attachment to a bone. The threaded portion includes a directional aperture sized to allow marrow to be drawn into the cannula. The directional aperture also allows the user to direct the aperture in a desired direction within the bone for acquisition of the marrow. The distal end of the cannulated fastener includes a connector which may be in the form of a Luer lock to allow vacuum to be applied to the cannula for drawing the marrow into a syringe or the like.

Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

Abstract: The present invention provides for a bone fixation device, an implantation instrument, and system which are useful in bone fixation surgeries. The bone fixation device of the instant invention allows the surgeon the ability to navigate the rod while being inserted into a pedicle screw assembly through a non-linear pathway by incrementally changing the direction of travel as desired.

Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

Abstract: The present invention provides an orthopedic surgical tool for moving an implant to a surgical sight and installing the implant. The tool allows the surgeon the ability to navigate the implant through a surgical tube, then rotate the implant after reaching the sight and effect installation of the implant, and then effect its release from the tool. The implant can be rotated at any time during its installation within the constraints of other surgical devices.

Abstract: The present invention relates to orthopedic implants. More specifically, the present invention is a series of orthopedic implants constructed from biocompatible material, each including a plurality of markers constructed from bioactive glass material, some of which are radio-opaque. In addition to providing recognizable markers for use by the surgeon implanting the device, the bioactive glass markers provide a lattice structure which allows for the in-growth of bone into portions of the implant. The in-growth provides enhanced structural integrity between the implant and the bone structure of the patient and may shorten healing time.

Abstract: The invention involves a device and method for acquiring bone marrow aspirate. The system includes an elongated cannulated fastener having a threaded end for attachment to a bone. The threaded portion includes a directional aperture sized to allow marrow to be drawn into the cannula. The directional aperture also allows the user to direct the aperture in a desired direction within the bone for acquisition of the marrow. The distal end of the cannulated fastener includes a connector which may be in the form of a Luer lock to allow vacuum to be applied to the cannula for drawing the marrow into a syringe or the like.

Abstract: The present invention relates to therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. In one particular embodiment, the pharmaceutical composition can have the structural moiety of formula (I) or a pharmaceutically-acceptable salt of said compound: wherein group A is selected from the formulae Group B is aryl, R1 is an optionally substituted aryl ring, an optionally substituted benzyl ring, CH3, or C2 to 6 alkyl, and R2 is hydrogen, an alkyl group, a halogen, or —(CH2)nN(CH3)2 where n is an integer from 1 to 3.

Abstract: The present invention relates to novel compounds of formula (I) suitable e.g. as therapeutic agents for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. The present invention also relates to processes for making said agents.

Abstract: The present invention provides for a bone fixation device, an implantation instrument, and system which are useful in bone fixation surgeries. The bone fixation device of the instant invention allows the surgeon the ability to navigate the rod while being inserted into a pedicle screw assembly through a non-linear pathway by incrementally changing the direction of travel as desired.

Abstract: The present invention provides an orthopedic surgical tool for moving an implant to a surgical sight and installing the implant. The tool allows the surgeon the ability to navigate the implant through a surgical tube, then rotate the implant after reaching the sight and effect installation of the implant, and then effect its release from the tool. The implant can be rotated at any time during its installation within the constraints of other surgical devices.

Abstract: The present invention provides for a bone fixation device, an implantation instrument, and system which are useful in bone fixation surgeries. The bone fixation device of the instant invention allows the surgeon the ability to navigate the rod while being inserted into a pedicle screw assembly through a non-linear pathway by incrementally changing the direction of travel as desired.

Abstract: The present invention provides an orthopedic surgical tool for moving an implant to a surgical sight and installing the implant. The tool allows the surgeon the ability to navigate the implant through a surgical tube, then rotate the implant after reaching the sight and effect installation of the implant, and then effect its release from the tool. The implant can be rotated at any time during its installation within the constraints of other surgical devices.

Abstract: A magnetic tracking tag for animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of a predator's gut. The degradation of the pH sensitive material causes a change in a detectable magnetic field of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: The present invention relates to novel therapeutic agents suitable for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes.

Abstract: A magnetic tracking tag for animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of a predator's gut. The degradation of the pH sensitive material causes a change in a detectable magnetic field of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: The present invention relates to novel compounds of formula (I) suitable e.g. as therapeutic agents for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. The present invention also relates to processes for making said agents.

Abstract: This disclosure includes methods utilizing lignin or modified lignin compositions to reduce undesirable effects of unwanted microbial growth in fermentation media or animal feed, including lignin or modified lignin compositions that may be used in or for such methods.

Abstract: A tracking tag for aquatic animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of an animal's gut. The degradation of the pH sensitive material causes a change in a detectable characteristic of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: The present invention provides an orthopedic surgical tool for moving an implant to a surgical sight and installing the implant. The tool allows the surgeon the ability to navigate the implant through a surgical tube, then rotate the implant after reaching the sight and effect installation of the implant, and then effect its release from the tool. The implant can be rotated at any time during its installation within the constraints of other surgical devices.