Abstract: Single-domain monoclonal antibodies that specifically bind B7H3 (also known as CD276) are described. The single-domain antibodies include camel VHH and rabbit VH domain nanobodies selected from phage display libraries. Chimeric antigen receptors (CARs) and other antibody conjugates targeted to B7H3 are also described. The single-domain antibodies and conjugates thereof can be used for the diagnosis and treatment of B7H3 expressing solid tumors.

Abstract: A method implemented to provide a virtual network to tenants requiring bandwidth in a cloud computing environment is disclosed. The method starts with receiving a request for a task at a network device, the request including a first parameter indicating VMs required, a second parameter indicating bandwidths the required VMs need, a third parameter indicating a duration of the task, and a fourth parameter indicating a deadline of the task. The network device then selects a starting time and a bandwidth allocation of the task, where the bandwidth allocation is shrank to be smaller than the second parameter indicating, and where the selection aims at minimizing a measurement of cloud resource utilization considering consumptions of both VMs and bandwidth. Then the network device allocates VMs for the request at the starting time with the bandwidth allocated at a particular location in the cloud computing environment.

Abstract: Provided are human antibodies that specifically bind to HBV Pre-S1 domain ligand and inhibit HBV or HDV infection, antibodies binding to a set of amino acid residues that are critical for viral receptor engagement, and uses of these antibodies to prevent, or treat or diagnose HBV or HDV infection.

Abstract: The present disclosure discloses an optical module including: a circuit board; a housing assembly divided by a separation board into a first portion and a second portion that are stacked one above the other, wherein a light-emitting cavity is formed in the second portion, and a partition wall is provided in the first portion to separate the first portion into a light-receiving cavity and a slot, and is provided with a plurality of light-passing holes via which the light-receiving cavity is in communication with the slot; an optical fiber adapter disposed in the housing assembly and in communication with the light-receiving cavity; a light-emitting assembly arranged in the light emitting cavity and electrically connected to the circuit board, wherein heat generated by the light-emitting assembly is conducted to a surface of the housing assembly via the partition wall; and a light-receiving assembly.

Abstract: A system includes an input voltage node configured to provide an input voltage. The system also includes a load and a switching converter coupled between the input voltage node and the load. The switching converter is configured to provide an output voltage to the load based on the input voltage. The switching converter includes gate driver circuitry and a comparator coupled to the gate driver circuitry. The switching converter also includes a constant ripple injection circuit coupled to the comparator. The constant ripple injection circuit is configured to provide a positive current sense signal and a negative current sense signal to the comparator based on the input voltage and the output voltage.

Abstract: Provided is a display module. The display module includes a first display panel including a first edge sealing region; a second display panel including a second edge sealing region, wherein the second display panel and the first display panel are disposed in a same layer and spliced with each other, and the second edge sealing region is abutted against the first edge sealing region; and a third display panel disposed on backlight sides of the first display panel and the second display panel, wherein both an orthographic projection of the first edge sealing region onto the third display panel and an orthographic projection of the second edge sealing region onto the third display panel fall within a display region of the third display panel; wherein the first display panel, the second display panel and the third display panel are all liquid-crystal display panels.

Abstract: A voltage command estimator is configured to estimate a minimum required variable DC bus voltage based on the first direct-axis current/voltage command, the first quadrature-axis current/voltage command, the second direct-axis current/voltage command, and the second quadrature-axis current/voltage command for a respective time interval. The voltage command estimator is configured to provide the estimated minimum required variable DC bus voltage to a voltage regulator to adjust the observed voltage level of the variable DC voltage bus to the estimated minimum required variable DC bus voltage to maintain the operation, as commanded by the voltage/current commands, of the first electric machine under the first variable load and the second electric machine under the second variable load at the time interval.

Abstract: The present application provides an image sensor, a global shutter control method and a computer storage medium. The image sensor includes a pixel array, where the pixel array includes a plurality of columns of pixels, or the pixel array includes a plurality of groups of sub-pixel arrays, each group of sub-pixel arrays including a plurality of columns/rows of pixels; and a processor module which triggers the pixel array on the basis of an instruction. According to the control method, consistency of an average delay of the columns/rows or groups in the pixel array is achieved by dynamic averaging. In addition, the consistency cannot be affected by external conditions such as a process, a power supply or the temperature. A high instantaneous current caused by using a global shutter manner is avoided, and at the same time, there is no need for a digital processor to perform column-by-column or row-by-row correction at a back end after exposure is not required, so as to reduce hardware cost and test cost.

Abstract: Various embodiments include a method for labeling a data point comprising executing a labeling operation on a target data set, wherein the target data set comprises a plurality of data points, each data point representing a service instance. The labeling operation comprises dividing the target data into subsets. For each subset, then: receiving input designating a mark for a first data point, illustrating the situation of the service instance represented by the data point; determining whether the similarity between the mark and a mark previously designated for a second data point in the target data set satisfies a preset condition; if the condition is not satisfied, taking the first subset as a target data set to re-execute the labeling operation; and if the condition is satisfied, setting, for each data point, a mark associated with the mark previously designated for a data point in the target data set.

Abstract: Provided are human antibodies that specifically bind to HBV Pre-S1 domain ligand and inhibit HBV or HDV infection, antibodies binding to a set of amino acid residues that are critical for viral receptor engagement, and uses of these antibodies to prevent, or treat or diagnose HBV or HDV infection.

Abstract: This application discloses a face anti-spoofing recognition method and apparatus, a device, and a storage medium, and relates to the field of artificial intelligence (AI) technologies. The method is performed by a computer device, including: acquiring face video data including a to-be-detected face; detecting eye contours of the to-be-detected face from image frames of the face video data, and generating an eye contour sequence; performing eye movement probability prediction based on the eye contour sequence, and generating an eye movement state sequence; acquiring a first dataset and a second dataset in the eye movement state sequence; determining a probability of existence of an abnormal blink behavior of the to-be-detected face according to the first dataset and the second dataset; and determining that the to-be-detected face is a real face in a case that the probability is less than a predetermined threshold.

Abstract: The present disclosure provides a cross-linking enhanced meta-aramid and a preparation method therefor. In the method, an isocyanate is used as a cross-linking agent, treatment is performed for a period of time at a certain temperature after a catalyst is added, and then water washing, drying, and heat setting are performed to prepare a high-strength meta-aramid. With the present disclosure, a cross-linked meta-aramid is prepared and has an improved binding force between fibers and has excellent mechanical properties and high temperature resistance.

Abstract: A voltage command estimator is configured to estimate a minimum required variable DC bus voltage based on the first direct-axis current/voltage command, the first quadrature-axis current/voltage command, the second direct-axis current/voltage command, and the second quadrature-axis current/voltage command for a respective time interval. The voltage command estimator is configured to provide the estimated minimum required variable DC bus voltage to a voltage regulator to adjust the observed voltage level of the variable DC voltage bus to the estimated minimum required variable DC bus voltage to maintain the operation, as commanded by the voltage/current commands, of the first electric machine under the first variable load and the second electric machine under the second variable load at the time interval.

Abstract: A device includes an operational amplifier having a first input, a second input and an output, the operational amplifier configured to generate a first signal at the output. The device includes a reference resistor divider having a first and second resistor, a first terminal of the first resistor coupled to the second input of the operational amplifier. A second terminal of the first resistor is coupled to a first terminal of the second resistor and a second terminal of the second resistor coupled to an electrically neutral terminal. The device includes a voltage to current (V2I) converter having an input and an output, the input coupled to the output of the operational amplifier, and the V2I converter configured to generate a second signal at the output of the V2I converter. The device includes a switch coupled to the output of the V2I converter and to the reference resistor divider.

Abstract: An optical module includes a circuit board and a light emitting assembly. The circuit board includes a first circuit board ground line, a second circuit board ground line and a circuit board signal line. The light emitting assembly is connected to the circuit board, and the light emitting assembly includes a spacer and a laser chip. The spacer includes a first spacer ground line, a second spacer ground line and a spacer signal line. The first spacer ground line is connected to the second spacer ground line through a fourth connection line; or the first spacer ground line is connected to the second circuit board ground line through a fifth connection line; or the second spacer ground line is connected to the first circuit board ground line through a sixth connection line; or the first circuit board ground line is connected to the second circuit board ground line through a seventh connection line.

Abstract: A converter system includes a first switch, a sample-and-hold unit configured to provide a comparison signal based on a feedback signal when the first switch is switched off, and hold the comparison signal independent from the feedback signal when the first switch is switched on, and a pulse-width-modulation (PWM) generator, coupled between the sample-and-hold unit and first switch, configured to generate a PWM signal based on the comparison signal, wherein the first switch is configured to be switched on and off based on the PWM signal.

Abstract: The present invention belongs to the field of genetic engineering, and particularly relates to a genetically engineered dual-targeting chimeric antigen receptor. The present invention provides a genetically engineered dual-targeting chimeric antigen receptor and a host cell thereof in response to up-regulated expression of PD-L1 in tumor cells and immune cells after these cells are exposed to malignant serosal cavity effusion. The dual-targeting chimeric antigen receptor provided by the present invention competitively binds to PD-L1 to transform an inhibition signal of PD-L1 into an activation signal and to enhance the killing activity of T cells; meanwhile, 4-1BB introduced downstream thereof can promote proliferation and survival of T cells. In addition, the present invention also discloses a host cell expressing the above dual-targeting antigen receptor and a use thereof in preventing or treating solid tumors.

Abstract: Provided are methods of diagnosing lung cancer in a human, comprising the steps of: (a) isolating genomic DNA from a bronchial washing sample or bronchial brush from a human, detecting the methylation status of a plurality of genes consisting of HOXA9, SHOX2, SCT and HOXA7 are present in said genomic DNA, wherein each of said gene comprises at least one CpG island which may be methylated, wherein the presence of a hypermethylation status of at least two of the genes is indicative of the presence of lung cancer in said human.

Abstract: The disclosure relates to a method, device, apparatus, and storage medium. The method includes recognizing voice data inputted by a user; obtaining a voice text corresponding to the voice data; obtaining, based on the voice text, a text to-be-input corresponding to the voice data, wherein the text to-be-input includes a plurality of words constituting a phrase or a sentence; and displaying the text to-be-input in an input textbox of an input interface.

Abstract: The present invention relates to use of a quaternary ammonium salt-type anthraquinone-based active material, and a salt cavern organic aqueous redox flow battery. The quaternary ammonium salt-type anthraquinone-based active material is used as a negative active material in a salt cavern battery, and a quaternary ammonium salt group is introduced, which can improve the solubility of anthraquinone in a neutral sodium chloride solution, thereby increasing the energy density of the battery. Also, the material has a relatively good stability, without the need for charging and discharging under the protection of an inert gas environment.