Abstract: The present application relates to an antigen-binding polypeptide that specifically binds to B7H3, comprising at least one complementarity-determining region (CDR) of an antibody heavy chain variable region (VH), wherein the VH comprises an amino acid sequence set forth in SEQ ID NO: 25. The present application further relates to a chimeric antigen receptor comprising the antigen-binding polypeptide and a universal CAR-T cell comprising the chimeric antigen receptor. The CAR-T cell recognizes a surface antigen of a tumor cell and knocks out TCR and HLA-A genes expressed by the cell at the same time, so that the immune rejection caused by an allogeneic CAR-T therapy is reduced, the survival time of the cell is prolonged, and the anti-tumor effect is improved.

Abstract: Various embodiments of the teachings herein include methods for presenting data integrity of a transformer. An example method includes: acquiring a data set of each of multiple transformers within a predetermined time period; generating a first chart of the multiple transformers, the first chart containing a first feature corresponding to each data point in each data set and adapted to present the data integrity of said each data point; and presenting the first chart.

Abstract: A machine learning (ML) controller and method for systems that can learn to stabilize them based on measurements of an unstable system. This allows for training on a system not yet controlled and for continuous learning as the stabilizer operates. The controller has improved performance on unstable systems compared to similar technologies, especially complex ones with many inputs and outputs. Furthermore, there is no need for modelling the physics, and the controller can adapt to un-analyzed or partially analyzed systems.

Abstract: The present disclosure provides a shift register unit, a gate driver circuit, and a display device, belonging to the field of display technology, which can solve the problem of unstable threshold voltage and current leakage of thin film transistors in existing shift register units. The shift register unit in the present disclosure includes: an input subcircuit, an output subcircuit, a pull-down control subcircuit, a pull-down subcircuit, a first noise reduction subcircuit, a first auxiliary control subcircuit, and a second auxiliary control subcircuit. The first auxiliary control subcircuit is configured to write the third reference level signal to the pull-down control node when the pull-down node is the first reference level signal, and control the pull-down subcircuit to be closed to control the first noise reduction subcircuit to be open.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; an actuator mechanism configured to position one or more heads proximate to a corresponding disk surface of the one or more disks; and one or more processing devices. The one or more processing devices are configured to apply a pre-bias current to the assistive energy emitter at a first value while the selected head is positioned proximate to one or more spiral patterns on the corresponding disk surface. The one or more processing devices are further configured to apply the pre-bias current to the assistive energy emitter at a boosted value while the selected head is not positioned proximate to the one or more spiral patterns, wherein the boosted value is greater than the first value.

Abstract: Various illustrative aspects are directed to a data storage device including one or more disks, an actuator mechanism configured to position a selected head among one or more heads proximate to a corresponding disk surface among the one or more disks, the selected head comprising a write element and an assistive energy emitter, and one or more processing devices configured to, individually or in combination: apply an assistive energy current to the assistive energy emitter while refraining from applying a write current to the write element, and vary a level of the assistive energy current over time while refraining from applying the write current to the write element.

Abstract: Aspects of the disclosure relate to methods for expressing one or more Ganglioside GM3 synthase (GM3S) isoforms in a cell or subject. In some aspects, the disclosure relates to methods for treating GM3 synthase deficiency in a subject in need thereof by administering an rAAV expressing one or more Ganglioside GM3 synthase (GM3S) isoforms via intracerebroventricular (ICV) administration.

Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional BCKDHA protein, which is the E1-alpha subunit of the branched-chain alpha-keto acid (BCAA) dehydrogenase complex, and/or BCKDHB, which is the E1-beta subunit of the branched-chain alpha-keto acid (BCAA) dehydrogenase complex in a subject. In some embodiments, the disclosure provides methods of treating a subject having Maple Syrup Urine Disease (MSUD).

Abstract: A light-emitting substrate includes a substrate, a plurality of sub-pixels, a first light extraction layer and a second light extraction layer. Each sub-pixel includes a light-emitting element and a light conversion pattern disposed on a light-exit side of the light-emitting element. The plurality of sub-pixels include at least one first sub-pixel. The first light extraction layer is disposed on a side of the first sub-pixel away from the light-emitting element, and at least located in a region where the at least one first sub-pixel is located. The first light extraction layer includes first transparent substrate(s) and optically active substances added in each first transparent substrate. The second light extraction layer is disposed on a side of the first light extraction layer away from the light-emitting element. A refractive index of the second light extraction layer is smaller than a refractive index of the first light extraction layer.

Abstract: A matrix compression/decompression accelerator (MCA) system/method that coordinates lossless data compression (LDC) and lossless data decompression (LDD) transfers between an external data memory (EDM) and a local data memory (LDM) is disclosed. The system implements LDC using a 2D-to-1D transformation of 2D uncompressed data blocks (2DU) within LDM to generate 1D uncompressed data blocks (1DU). The 1DU is then compressed to generate a 1D compressed superblock (CSB) in LDM. This LDM CSB may then be written to EDM with a reduced number of EDM bus cycles. The system implements LDD using decompression of CSB data retrieved from EDM to generate a 1D decompressed data block (1DD) in LDM. A 1D-to-2D transformation is then applied to the LDM 1DD to generate a 2D decompressed data block (2DD) in LDM. This 2DD may then be operated on by a matrix compute engine (MCE) using a variety of function operators.

Abstract: The present disclosure provides an ECS information processing method, an ECS information processing device and a communication device. The ECS information processing method includes determining, by an SMF, first ECS configuration information in accordance with at least one of position information about a UE, a service range of an ECS or a selection priority level of the ECS. The first ECS configuration information includes at least one of an address of the ECS, the service range of the ECS, the selection priority level of the ECS or attribute information about the ECS.

Abstract: A radar system includes a set of transmitters and a processor coupled to the set of transmitters, which includes first, second, third and fourth transmitters. In operation, the processor generates a first chirp of a set of chirps, in which outputs of the first and second transmitters are modulated by a first phase and outputs of the third and fourth transmitters are modulated by a second phase; and generate a second chirp of the set of chirps, in which outputs of the first and fourth transmitters are modulated by the first phase and outputs of the second and third transmitters are modulated by the second phase.

Abstract: A computer-implemented method includes: receiving an inquiry request message identifying a first payment transaction having a plurality of transaction parameters and a risk score, where the risk score is generated by a machine-learning model based on the plurality of transaction parameters; for each transaction parameter of the plurality of transaction parameters, perturbing a value of the transaction parameter and re-analyzing the first payment transaction with the machine-learning model to generate a perturbed risk score based on the perturbed transaction parameter; determining at least one impact parameter from the plurality of transaction parameters by comparing the perturbed risk scores generated for each of the plurality of transaction parameters; and generating an inquiry response message based on the at least one impact parameter.

Abstract: In accordance with described examples, a method determines if a velocity of an object detected by a radar is greater than a maximum velocity by receiving on a plurality of receivers at least one frame of chirps transmitted by at least two transmitters and reflected off of the object. A velocity induced phase shift (?d) in a virtual array vector S of signals received by each receiver corresponding to a sequence of chirps (frame) transmitted by each transmitter is estimated. Phases of each element of virtual array vector S are corrected using ?d to generate a corrected virtual array vector Sc. A first Fourier transform is performed on the corrected virtual array vector Sc to generate a corrected virtual array spectrum to detect a signature that indicates that the object has an absolute velocity greater than a maximum velocity.

Abstract: The present disclosure provides a method for interactions between traffic and transportation systems based on a sustainable development goal SDG framework. The method includes: step 1: extending and perfecting, through a Delphi method, sustainable transport indicators under an SDG framework; step 2: drawing first-order gaming and synergistic effect between traffic SDGs and synergy through a typological cross-impact matrix and in combination with a panel vector autoregressive model; step 3: parsing a multi-goal second-order interaction mechanism after probability coefficients are introduced, to determine a leverage point of a multi-goal system with maximum synergistic effect; and step 4: determining stability of the leverage point of the multi-goal system based on sensitivity analysis and sectoral analysis.

Abstract: The present invention relates to the technical field of functional materials, and in particular to an amorphous metal oxide hollow multi-shell material and a preparation method therefor and an application thereof. The method includes the following steps: 1) performing a heating reaction on a carbon source aqueous solution, filtering, washing, and drying to obtain a carbon sphere template; 2) dispersing the carbon sphere template obtained in step 1) in a first metal salt solution, heating, adsorbing, and drying to obtain a first solid precursor; 3) dispersing the solid precursor obtained in step 2) in a second metal salt solution again, adsorbing, and drying to obtain a second solid precursor; and 4) calcinating the second solid precursor obtained in step 3) to obtain the amorphous metal oxide hollow multi-shell material.

Abstract: A modified immune effector cell may be one in which the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHCI, MHCII) in the modified immune effector cell are inhibited in a T cell. Such a modified immune effector cell may include a chimeric antigen receptor (CAR) targeting GD2. Such a modified immune effector cell may knock out TCR and HLA-A genes expressed by the cell while recognizing surface antigens of tumor cells, so that multiple effects of improving the anti-tumor effect of CAR-T cells, prolonging the survival time of the cells, and reducing the immune rejection response caused by allogeneic cell therapy may be reduced.

Abstract: Described are a system, method, and computer program product for state compression in stateful machine learning models. The method includes receiving a transaction authorization request for a transaction and loading at least one encoded state of a recurrent neural network (RNN) model from a memory. The method further includes decoding the at least one encoded state by passing each encoded state through a decoder network to provide at least one decoded state. The method further includes generating at least one updated state and an output for the transaction by inputting at least a portion of the transaction authorization request and the at least one decoded state into the RNN model. The method further includes encoding the at least one updated state by passing each updated state through an encoder network to provide at least one encoded updated state, and storing the at least one encoded updated state in the memory.

Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.