Abstract: The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use. In some embodiments, a multimeric coding nucleic acid (MCNA) comprises two or more encoding polynucleotides linked via 3? ends such that the multimeric coding nucleic acid compound comprises two or more 5? ends.

Abstract: A quantum processor comprises a first set of qubits comprising a first plurality of substantially parallel qubits; a second set of qubits comprising N successive groups of a plurality of qubits (1, 2, . . . , N), wherein N is greater than or equal to two; wherein each group of qubits comprises a plurality of substantially parallel qubits; wherein each qubit of the first plurality of substantially parallel qubits of the first set of qubits crosses substantially perpendicularly a portion of the plurality of substantially parallel qubits of a first group of the second set of qubits; wherein each qubit of any given group of the second set of qubits crosses substantially perpendicularly a portion of the plurality of substantially parallel qubits of a successive group of the second set of qubits and a plurality of couplers, each coupler for providing a communicative coupling at a crossing of two qubits.

Abstract: The present invention provides methods for large-scale production of a composition enriched for full-length mRNA molecules using an SP6 RNA polymerase and compositions produced using such methods and uses thereof.

Abstract: The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, a step of centrifuging an mRNA suspension in a centrifuge comprising a porous substrate at a speed sufficient to remove process contaminants and to precipitate purified mRNA composition onto the porous substrate.

Abstract: The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, steps of forming an mRNA slurry, stirring the slurry, and vacuum or pressure filtering the slurry.

Abstract: A method for estimating a thermodynamic property of a quantum Ising model with transverse field is disclosed.

Abstract: Described embodiments are directed toward prosthetic heart valve leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic heart valve comprises a leaflet frame having a generally tubular shape with attached film. The leaflet frame defines a plurality of leaflet windows. The film defines at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame has substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides diverge from the leaflet base, wherein the leaflet base is substantially flat.

Abstract: A method and system are disclosed for improving a policy for a stochastic control problem, the stochastic control problem being characterized by a set of actions, a set of states, a reward structure as a function of states and actions, and a plurality of decision epochs, the method comprising using a sampling device obtaining data representative of sample configurations of a Boltzmann machine, obtaining initialization data and an initial policy for the stochastic control problem; assigning data representative of an initial weight and a bias of respectively each coupler and each node and the transverse field strength of the Boltzmann machine to the sampling device; until a stopping criterion is met generating a present-epoch state-action pair, amending data representative of none or at least one coupler and at least one bias, performing a sampling corresponding to the present-epoch state-action pair to obtain first sampling empirical means, obtaining an approximation of a value of a Q-function at the present-e

Abstract: The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use. In some embodiments, a multimeric coding nucleic acid (MCNA) comprises two or more encoding polynucleotides linked via 3? ends such that the multimeric coding nucleic acid compound comprises two or more 5? ends.

Abstract: A quantum processor comprises a first set of qubits comprising a first plurality of substantially parallel qubits; a second set of qubits comprising N successive groups of a plurality of qubits (1, 2, . . . , N), wherein N is greater than or equal to two; wherein each group of qubits comprises a plurality of substantially parallel qubits; wherein each qubit of the first plurality of substantially parallel qubits of the first set of qubits crosses substantially perpendicularly a portion of the plurality of substantially parallel qubits of a first group of the second set of qubits; wherein each qubit of any given group of the second set of qubits crosses substantially perpendicularly a portion of the plurality of substantially parallel qubits of a successive group of the second set of qubits and a plurality of couplers, each coupler for providing a communicative coupling at a crossing of two qubits.

Abstract: Described embodiments are directed toward prosthetic heart valve leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic heart valve comprises a leaflet frame having a generally tubular shape with attached film. The leaflet frame defines a plurality of leaflet windows. The film defines at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame has substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides diverge from the leaflet base, wherein the leaflet base is substantially flat.

Abstract: A valve assembly for attaching to a live gas line at the shut off, so as to insert a camera cable into the open line through the valve assembly, while the live line is sealed off.

Abstract: In various embodiments, the medical device delivery system described herein can be configured to position and deliver a medical device in a body lumen. The medical device delivery system can comprise an elongate member, a medical device and a leash. During deployment, the medical device can be tethered to the catheter by the leash, to stabilize and prevent unwanted shifting of the medical device as it deploys at the treatment site.

Abstract: Described embodiments are directed toward prosthetic heart valve leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic heart valve comprises a leaflet frame having a generally tubular shape with attached film. The leaflet frame defines a plurality of leaflet windows. The film defines at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame has substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides diverge from the leaflet base, wherein the leaflet base is substantially flat.

Abstract: An embodiment of the invention is an actuator controller for use in an actuator assembly. The actuator controller includes a processor for controlling an actuator associated with the actuator controller. A communication device is in communication with the processor. The communication device receives control commands from a master controller and is capable of communicating in multiple languages. A memory is accessible by the processor and the processor determines the language of the control commands and retrieves a control program from the memory corresponding to the language.

Abstract: A method of monitoring faults in a vehicle bulb circuit including bulb and a fuse. The method includes detecting acceleration of the vehicle and comparing the acceleration of the vehicle to a limit. Based on the relationship of the acceleration to the limit, it is determined whether a fault exists in the bulb circuit. An indicator is activated in response to detecting a fault in the bulb circuit. A system for implementing the method is also disclosed.

Abstract: A method for automatically calibrating a vehicle speed sensor signal input to an electronic control system includes operating a vehicle at a reference speed. A speed signal pulse period, generated by a vehicle speed sensor operatively coupled to the vehicle, is measured. The measured speed signal pulse period is then compared to a stored set of pulse period scalings within the electronic control system. A corresponding pulse period scaling is stored in memory if the measured speed signal pulse period matches one of the stored set of pulse period scalings.

Abstract: An embodiment of the invention is an actuator controller for use in an actuator assembly. The actuator controller includes a processor for controlling an actuator associated with the actuator controller. A communication device is in communication with the processor. The communication device receives control commands from a master controller and is capable of communicating in multiple languages. A memory is accessible by the processor and the processor determines the language of the control commands and retrieves a control program from the memory corresponding to the language.

Abstract: An exemplary embodiment of the invention is an actuator assembly having a controller integrated into the actuator assembly. The controller includes a memory for storing test cycle data and a processor in communication with the memory. The processor accesses the test cycle data. A communication port is in communication with the processor and in communication with an actuator and a sensor. During a test mode, the processor provides position commands to the actuator and receives a sensor signal from the sensor. The processor detects the presence of faults in response to the sensor signal and stores the faults in the memory.

Abstract: An embodiment of the invention is a printed wiring board mounting structure for use in a brushless motor commutation controller. The printed wiring board includes interconnects for receiving Hall-effect sensors. The interconnects include a first set of interconnects dedicated to a first Hall-effect sensor group having a first plurality of Hall-effect sensors having a first Hall-effect sensor package. The interconnects also include a second set of interconnects dedicated to a second Hall-effect sensor group having a second plurality of Hall-effect sensors having a second Hall-effect sensor package.