Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Abstract: A reusable decorative canister apparatus includes a housing, an access element, and a separator element. The access element and the housing form a hollow interior space configured to receive a disposable wipe insert containing multiple disposable wipes. The access element includes a sidewall extending between a bottom edge and a top edge. The sidewall includes an elevated portion, a secondary portion opposite the elevated portion, and a height from the bottom edge to the top edge that decreases from the elevated portion towards the secondary portion. The separator element is coupled to an inside perimeter of the top edge adjacent to the elevated portion and is configured to receive one of the disposable wipes therethrough.

Abstract: Provided herein are imaging agent-loaded cryopreserved platelets and platelet derivatives, such as MRI agent-loaded platelets and platelet derivatives, and methods of preparing and using the same. In some embodiments, methods of loading MRI agents into platelets include contacting platelets with an MRI agent and a cell penetrating peptide. In some embodiments, methods of preparing MRI agent-loaded cryopreserved platelets or platelet derivatives in a dried powder, wherein the MRI agent-loaded cryopreserved platelets or the MRI agent-loaded platelet derivatives comprise an MRI agent complex covalently bonded to the surface of the cryopreserved platelets or the platelet derivatives.

Abstract: Provided are computer-implemented methods for determining a care provider based on a care request which may include receiving data associated with a care request, the data associated with the care request transmitted by a device associated with a care recipient; determining one or more values corresponding to one or more parameters of the care request; determining one or more weighted scores corresponding to one or more care providers based on the one or more values corresponding to the one or more parameters of the care request; and selecting a care provider from among the one or more care providers based on the one or more weighted scores. In some non-limiting embodiments or aspects, methods may include generating a care request for the care provider selected from among the one or more care providers. Systems and computer program products are also provided.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: An intermittent catheter assembly that has a catheter having a proximal end for insertion into the body and a distal end; and a fluid collection bag arranged to receive fluid from the distal end of the catheter, wherein the fluid collection bag comprises a hand strap. The hand strap may comprise two ends, each end being attached to the fluid collection bag at substantially the same position on the fluid collection bag.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from H3 influenza virus that are immunogenic and are capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 virus following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, vaccines, virus-like particles (VLPs) and compositions comprising the immunogens and vaccines. Methods of generating an immune response in a subject by administering the immunogens, vaccines, VLPs, or compositions thereof are provided. In particular, the immunogens comprise the hemagglutinin (HA) protein of H3 influenza virus strains.

Abstract: A method may include serially joining different video clips from videos of different historical competitions to form a composite video competition, the different video clips comprising an indeterminate subset of clips drawn from a larger pool of clips, wherein each clip from a historical competition has an associated partial result contribution to a final result of the historical competition further include presenting a result during the composite video competition, the result comprising a linked combination of the partial result contributions from the different video clips.

Abstract: An exhaust discharge system is disclosed. The exhaust discharge system comprises an exhaust stack including a first conduit and a second conduit. The first conduit defines a first flow passageway and arranged around a first longitudinal axis. The first conduit including a skirt portion and a body portion disposed downstream of the skirt portion, and the skirt portion is oriented to slope outward from the body portion. The second conduit is disposed downstream of the first conduit. The second conduit defines a second flow passageway and is arranged around a second longitudinal axis, the second conduit includes a sidewall and an exit port, the exit port having an exit-port cross-section, wherein the exit-port cross-section is oblong in shape. The second longitudinal axis is disposed at an intersection angle to the first longitudinal axis, the intersection angle in a range of 125° to 150°. The exhaust stack is configured to convey treated exhaust from the skirt portion to the exit port.

Abstract: Provided herein are MRI agent-loaded platelets, methods of preparing MRI agent-loaded platelets, and methods of using MRI agent-loaded platelets. In some embodiments, methods of loading MRI agents into platelets include contacting platelets with an MRI agent, a cell penetrating peptide, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Abstract: An actively Q-switched laser induced breakdown spectroscopy (LIBS) probe, utilizing an optical fiber, a pump beam transmitted through the optical fiber, a coupler, and a lens for collimating the pump beam. The actively Q-switched laser, coupled to a sensor which provides information to a computer that controls a high voltage pulser providing a pulse to a Pockels cell located within the laser which can selectively cause the laser to pulse, resulting in high energy pulses and a second lens for focusing the output pulse such that it creates a plasma or spark. The light from the spark is captured and directed back through an optical system to remote equipment for elemental and/or molecular analysis.

Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Abstract: To substantially eliminate torsional freeplay in a robotic tool changer having a ball-lock coupling mechanism, scallop-like features in the form of cross-contact recesses are formed in at least one of, and preferably both of, a bearing race in a tool assembly at the points of contact of rolling members, and in the opposing inner surfaces of bores containing the rolling members in a master assembly. The cross-contact recesses are sized and shaped to receive a rolling member, but have a central void, or channel, perpendicular to the rolling member's motion in torsional freeplay, which does not contact the rolling member. The cross-contact recess contacts the rolling member at contact areas on either side of the central void.

Abstract: An exhaust discharge system is disclosed. The exhaust discharge system comprises an exhaust stack including a first conduit and a second conduit. The first conduit defines a first flow passageway and arranged around a first longitudinal axis. The first conduit including a skirt portion and a body portion disposed downstream of the skirt portion, and the skirt portion is oriented to slope outward from the body portion. The second conduit is disposed downstream of the first conduit. The second conduit defines a second flow passageway and is arranged around a second longitudinal axis, the second conduit includes a sidewall and an exit port, the exit port having an exit-port cross-section, wherein the exit-port cross-section is oblong in shape. The second longitudinal axis is disposed at an intersection angle to the first longitudinal axis, the intersection angle in a range of 125° to 150°. The exhaust stack is configured to convey treated exhaust from the skirt portion to the exit port.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.