Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.

Abstract: A gas spring-powered fastener driver includes a cylinder, a moveable piston positioned within the cylinder, a driver blade attached to the piston and movable therewith between a ready position and a driven position, a lifter to move the driver blade from the driven position to the ready position, and a transmission including an output shaft operatively coupled to the lifter to provide torque to the lifter. The fastener driver also includes an input to provide torque to the transmission and a clutch positioned downstream of the input and operably coupled to the output shaft to limit an amount of torque transferred to the output shaft and the lifter. In response to an application of a reaction torque to the output shaft above a predetermined threshold, torque from the input is diverted from the output shaft via the clutch.

Abstract: An information preservation and conveyance system for providing information and effects to intelligent creatures in the future. The system provides durable containers with components secured inside and durable structure components, such as building bricks for example, mountable to a durable building, pyramid, or other structure, with at least one structure component having external surface information readable by a human. Higher density durable information providing components may be secured inside a durable container by resilient devices to absorb impact forces. Durable optical magnifier pictographic instructions and an optical magnifier or projector may be secured by durable containers, which can have a container opener durably mounted to exposed sections on the durable containers. The durable containers can contain audio generation apparatus, which optionally may teach a language, and any of a wide variety of types of information and articles of possible interest and value to a discoverer in the future.

Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Abstract: To substantially eliminate torsional freeplay in a robotic tool changer having a ball-lock coupling mechanism, scallop-like features in the form of cross-contact recesses are formed in at least one of, and preferably both of, a bearing race in a tool assembly at the points of contact of rolling members, and in the opposing inner surfaces of bores containing the rolling members in a master assembly. The cross-contact recesses are sized and shaped to receive a rolling member, but have a central void, or channel, perpendicular to the rolling member's motion in torsional freeplay, which does not contact the rolling member. The cross-contact recess contacts the rolling member at contact areas on either side of the central void.

Abstract: An exhaust discharge system is disclosed. The exhaust discharge system comprises an exhaust stack including a first conduit and a second conduit. The first conduit defines a first flow passageway and arranged around a first longitudinal axis. The first conduit including a skirt portion and a body portion disposed downstream of the skirt portion, and the skirt portion is oriented to slope outward from the body portion. The second conduit is disposed downstream of the first conduit. The second conduit defines a second flow passageway and is arranged around a second longitudinal axis, the second conduit includes a sidewall and an exit port, the exit port having an exit-port cross-section, wherein the exit-port cross-section is oblong in shape. The second longitudinal axis is disposed at an intersection angle to the first longitudinal axis, the intersection angle in a range of 125° to 150°. The exhaust stack is configured to convey treated exhaust from the skirt portion to the exit port.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: An exhaust discharge system and method of assembling is disclosed. The exhaust discharge system may comprises an ejector tube and an exhaust stack. The ejector tube includes an outlet having an outlet cross-section. The ejector tube is configured to convey treated exhaust to the outlet. The outlet cross-section is oriented at an outlet angle to a first horizontal plane. The exhaust stack includes a first conduit and a second conduit. The second conduit includes an exit port. The exit-port cross-section is oblong in shape.

Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.

Abstract: The invention relates to a computer implemented system and method for identification of comparables. The method may comprise: receiving input data from a plurality of data sources for a comparable, generating labeled training data for a function classifier by labeling historical search results for comparables, generating probabilistic training data for the primary product and service classifiers, training the primary product and service classifiers using the labeled training data and the probabilistic training data, determining the functions, products, services, and risks of the comparable using the corresponding classifiers, receiving attributes of a tested party, applying a scoring algorithm to calculate a similarity score for the comparable, generating a recommendation to accept the comparable, reject the comparable, or give additional scrutiny to determine acceptability, and automatically providing a written justification for the decision to accept or to reject the comparable.

Abstract: Disclosed herein are systems and methods for insertion tools for implanting electrode leads. In one embodiment, an insertion tool comprises a shaft having an outer cannula and an inner cannula. An actuator may be configured to transition the insertion tool between at least three configurations. In a first configuration, the inner cannula and the outer cannula are configured to receive the lead in the shaft. In a second configuration, the inner cannula and the outer cannula are configured to secure the lead in the shaft. In a third configuration, the inner cannula and the outer cannula are configured to cause the lead to separate from the insertion tool and implant in adjacent tissue.

Abstract: An exhaust discharge system and method of assembling is disclosed. The exhaust discharge system may comprises an ejector tube and an exhaust stack. The ejector tube includes an outlet having an outlet cross-section. The ejector tube is configured to convey treated exhaust to the outlet. The outlet cross-section is oriented at an outlet angle to a first horizontal plane. The exhaust stack includes a first conduit and a second conduit. The second conduit includes an exit port. The exit-port cross-section is oblong in shape.

Abstract: A robotic tool changer includes master and tool assemblies. When the master and tool assemblies are coupled, rolling members project from the master assembly and contact opposed sloped surfaces of a plurality of cutouts formed in a bearing race in the tool assembly. By contacting opposed sloped surfaces of a plurality of cutouts with the rolling members, torsional freeplay between the master and tool assemblies is eliminated or minimized.

Abstract: A system and method for collection and interpretation of data for determining impairment by intoxicant(s) in a subject at the point of collection utilizes of multiple sensors which may comprise both a live-cell assay in a disposable cartridge for determining the presence of intoxicant(s) and an eye scanner for determining vital signs and neurological state of the subject. The cartridge may be equipped to intake a sample, process it, and/or interact it with one or more eukaryotic cell-based biosensors. A cartridge may function as an optical interface to relay signals from the biosensors to a detector. The eye scanner may be equipped with optical sensors for the detecting both vital signs and neurological state. Each optical sensor may be spectrally filtered to identify a biomarker or set of biomarkers. Another method utilizes the eye scanner to train a model to identify additional biomarkers within the live-cell assay on a cartridge to increase the specificity for impairment by the primary analyte.

Abstract: Provided herein are methods and compositions using extracellular vesicles derived from fresh, frozen, or lyophilized platelets.

Abstract: The disclosed systems can regulate access to an online mode for a dynamic transportation matching system. For example, based on a provider efficiency parameter associated with the dynamic transportation matching system, the disclosed systems can prevent a transportation provider device from switching to the online mode within a geographic area. In addition, the disclosed systems can detect a pattern of behavior and, based on a comparison between the pattern of behavior and a behavioral threshold, cause a transportation provider device to switch from the online mode to an offline mode. Further, the disclosed systems can provide a map interface that indicates where a transportation provider device can switch from the offline mode to the online mode. Additionally, the disclosed systems can determine priorities associated with transportation provider devices and, based on the prioritization, selectively allow the transportation provider devices to switch from the offline mode to the online mode.

Abstract: Disclosed herein are systems and methods for sensor systems. In one embodiment, a system may include an implantable component and an external component. The implantable component may comprise a housing and an electrode array configured to receive a plurality of biopotential signals. The housing may comprise a wireless power receiver and a wireless data transmitter to transmit representations of the biopotential signals. The external component may comprise a wireless data receiver configured to receive the plurality of digital representations of the biopotential signals and a wireless power transmitter configured to provide power to the internal component. A shielding component may separate the wireless power transmitter from the wireless data receiver. An interface may be configured to communicate with a prosthesis and configured to cause the prosthesis to implement a voluntary motion based on the plurality of digital presentations of the biopotential signals.

Abstract: A method may include serially joining different video clips from videos of different historical competitions to form a composite video competition, the different video clips comprising an indeterminate subset of clips drawn from a larger pool of clips, wherein each clip from a historical competition has an associated partial result contribution to a final result of the historical competition further include presenting a result during the composite video competition, the result comprising a linked combination of the partial result contributions from the different video clips.