Patents by Inventor Daniel C. Sigg
Daniel C. Sigg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240016540Abstract: Methods of and systems for ablating cardiac tissue is disclosed. One example method includes monitoring an electrical signal of a heart of a patient. The electrical signal represents the heart beating. The method further includes determining, with an electronic processor and based on the electrical signal, an end-diastolic time period at an end of a diastolic time period during which diastole of the heart has occurred during a previous cardiac cycle. The method further includes determining, with the electronic processor and based on the electrical signal, that another cardiac cycle has begun. The method further includes causing, with the electronic processor, an electrode to deliver pulsed field ablation (PFA) energy to the heart during at least a portion of a time in which the end-diastolic time period of the another cardiac cycle is expected to occur.Type: ApplicationFiled: June 20, 2023Publication date: January 18, 2024Inventors: Daniel C. Sigg, Lars M. Mattison, Damijan Miklavcic
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Publication number: 20230255684Abstract: Evaluating a cardiac lesion formed by an ablation procedure, by receiving, by processing circuitry and following conclusion of delivery of ablation energy, a bioelectrical signal from an electrode proximate to a target location of cardiac tissue for the cardiac lesion; determining, by the processing circuitry, one or more characteristics of the received bioelectrical signal in a frequency band of the received bioelectrical signal; and estimating, by the processing circuitry, an efficacy of the cardiac lesion based on a comparison of the determined amplitude of the bioelectrical signal and a threshold amplitude.Type: ApplicationFiled: January 26, 2023Publication date: August 17, 2023Inventors: Megan M. Schmidt, Daniel C. Sigg, Lars M. Mattison, Tomaz Jarm, Jernej Stublar, Damijan Miklavcic, Nicolas Coulombe
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Patent number: 9943633Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.Type: GrantFiled: June 23, 2016Date of Patent: April 17, 2018Assignee: Medtronic Inc.Inventors: Daniel C. Sigg, Sarah Anne Audet, Tommy D. Bennett, Dwight H. Warkentin
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Publication number: 20160331884Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.Type: ApplicationFiled: June 23, 2016Publication date: November 17, 2016Inventors: Daniel C. SIGG, Sarah Anne AUDET, Tommy D. BENNETT, Dwight H. WARKENTIN
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Publication number: 20160325058Abstract: Example techniques and systems include managing delivery of a substance into an inhaled stream of air from a patient. For example, a system may include a housing configured to accept a medication canister containing a medication, the housing comprising a dispensing portion, a sensor configured to sense air flow within the dispensing portion, and a processor configured to transmit a signal indicative of the sensed air flow, wherein information associated with use of the pulmonary medication dosing device is generated by the computing device and based on the transmitted signal.Type: ApplicationFiled: July 15, 2016Publication date: November 10, 2016Inventors: Serafin Samson, Daniel C. Sigg, David Dieken, Seth Iverson, Jacob Blank, Paul Hattan
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Patent number: 9399091Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.Type: GrantFiled: September 30, 2009Date of Patent: July 26, 2016Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, Sarah Anne Audet, Tommy D. Bennett, Dwight H. Warkentin
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Publication number: 20150073288Abstract: Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.Type: ApplicationFiled: November 12, 2014Publication date: March 12, 2015Inventors: Michael R. Ujhelyi, Daniel C. Sigg
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Patent number: 8892197Abstract: Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.Type: GrantFiled: July 29, 2005Date of Patent: November 18, 2014Assignee: Medtronic, Inc.Inventors: Michael R. Ujhelyi, Daniel C. Sigg
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Patent number: 8852173Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.Type: GrantFiled: October 14, 2011Date of Patent: October 7, 2014Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, Michael R. Ujhelyi, Mary M. Morris
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Patent number: 8790295Abstract: A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.Type: GrantFiled: January 4, 2010Date of Patent: July 29, 2014Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, Prasanga Hiniduma-Lokuge, Mary Morris, Mike Ujhelyi
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Patent number: 8672917Abstract: A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.Type: GrantFiled: April 26, 2010Date of Patent: March 18, 2014Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, Prasanga D. Hiniduma-Lokuge, Mary M. Morris
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Patent number: 8565898Abstract: A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.Type: GrantFiled: April 28, 2005Date of Patent: October 22, 2013Assignee: Medtronic, Inc.Inventors: Vinod Sharma, Daniel C. Sigg
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Patent number: 8348884Abstract: A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g.Type: GrantFiled: May 28, 2008Date of Patent: January 8, 2013Assignee: Medtronic, Inc.Inventors: Keith R. Hildebrand, Michael R. Ujhelyi, Xiaohong Zhou, Daniel C. Sigg, Linda M. Page
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Patent number: 8332051Abstract: Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.Type: GrantFiled: May 18, 2010Date of Patent: December 11, 2012Assignee: Medtronic, Inc.Inventors: John L. Sommer, Daniel C. Sigg, James A. Coles, Jr.
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Publication number: 20120130303Abstract: A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.Type: ApplicationFiled: January 27, 2012Publication date: May 24, 2012Applicant: Medtronic, Inc.Inventors: Vinod Sharma, Daniel C. Sigg
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Patent number: 8126549Abstract: A cardiac ischemic protection system and method for conditioning a patient's heart is provided. The method can include detecting acute myocardial infarction, angina pectoris, silent ischemia, or stunning and providing closed-loop dyssynchronous pacing to the patient's heart to precondition and/or postcondition the patient's heart in order to reduce ischemic damage.Type: GrantFiled: July 15, 2008Date of Patent: February 28, 2012Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, James A. Coles, Jr., Dwight H. Warkentin, Deborah Ann Jaye
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Publication number: 20120035587Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.Type: ApplicationFiled: October 14, 2011Publication date: February 9, 2012Inventors: Daniel C. Sigg, Michael R. Ujhelyi, Mary M. Morris
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Patent number: 8076305Abstract: A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify Ih when compared with wild-type HCN. Methods for implementing each of the biologocal pacemakers include implanting each of biologocal pacemakers into cardiac tissue.Type: GrantFiled: November 30, 2006Date of Patent: December 13, 2011Assignee: Medtronic, Inc.Inventors: Daniel C. Sigg, Vinod Sharma, Yong-Fu Xiao
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Publication number: 20110123593Abstract: A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.Type: ApplicationFiled: January 18, 2011Publication date: May 26, 2011Applicant: Medtronic, Inc.Inventors: Daniel C. Sigg, Prasanga D. Hiniduma-Lokuge, Vinod Sharma, John L. Sommer
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Publication number: 20110077574Abstract: A medical device system including a physiological sensor and ultrafiltration unit senses a physiological signal in a patient and computes a fluid status measurement of the patient using the physiological signal. Ultrafiltration therapy is delivered to the patient according to a therapy delivery control parameter established in response to the fluid status measurement.Type: ApplicationFiled: September 30, 2009Publication date: March 31, 2011Applicant: Medtronic, Inc.Inventors: Daniel C. Sigg, Sarah Anne Audet, Tommy D. Bennett, Dwight H. Warkentin