Abstract: A medical system incorporating fluid delivery and lead delivery lumens dispense fluid into a volume of tissue. The fluid comprises or contains a pharmacologic, genetic, or biologic agent. The fluid may be dispensed initially during implantation or later using a minimally invasive medical procedure. A hollow tissue-piercing tip portion provides fluid delivery to the volume of tissue at one or more targeted sites. A medical electrical lead may be chronically implanted at the treated tissue site. The system includes a guide catheter having a fluid delivery lumen in communication with an active fixation, fluid dispensing member and a lead delivery lumen for deploying a medical lead. The system includes a medical lead having an active or passive fixation member and a central lumen through which a tip portion is deployed. The system may be used with implantable pulse generators, drug delivery pumps and the like.