Abstract: There is disclosed a receptacle mould defining a cavity in which a receptacle is mouldable. The receptacle mould comprises a guide channel for guiding, into the cavity, an expandable member that is usable to help mould the receptacle in the cavity. The guide channel has a first end and a second end, the second end opening into the cavity, and the expandable member is guidable through the guide channel from the first end to the second end and into the cavity. The guide channel has a first cross-sectional width at the first end and a second cross-sectional width at the second end, the second cross-sectional width being less than the first cross-sectional width.

Abstract: Method and system for method for communicating between a device and a server, the method comprising the steps of the server initiating device wake-up. Obtaining generic bootstrapping architecture, GBA, push information, GPI, including security credentials or information used to derive the security credentials. Sending a device wake-up message to the device, wherein the device a wake-up message includes the GPI. Authenticating the security credentials within the GPI to obtain a key.

Abstract: There is disclosed a method of forming a moulded receptacle, comprising: applying a fibre suspension onto a mould cavity wall of a receptacle mould, the fibre suspension at least partially coating the mould cavity wall. The method further comprises supplying a fluid into direct contact with the fibre suspension on the mould cavity wall at a pressure of between about 3.5 bar and about 10 bar for a period of less than about 60 seconds, such that the fluid presses the fibre suspension against the mould cavity wall so that liquid is removed from the fibre suspension and passes through apertures formed in the mould cavity wall to form the moulded receptacle on the mould cavity wall.

Abstract: Compositions including a sintered porous ultra-high-molecular-weight polypropylene material having a viscosity average molecular weight over 500,000, an average porc size ranging from 10 ?m to 200 ?m, and a porosity ranging from 20% to 60%. Devices and methods including such compositions.

Abstract: Vehicle platforms, and systems, subsystems, and components thereof are described. A self-contained vehicle platform or chassis incorporating substantially all of the functional systems, subsystems and components (e.g., mechanical, electrical, structural, etc.) necessary for an operative vehicle. Functional components may include at least energy storage/conversion, propulsion, suspension and wheels, steering, crash protection, and braking systems. Functional components are standardized such that vehicle platforms may be interconnected with a variety of vehicle body designs (also referred to in the art as “top hats”) with minimal or no modification to the functional linkages (e.g., mechanical, structural, electrical, etc.) therebetween. Configurations of functional components are incorporated within the vehicle platform such that there is minimal or no physical overlap between the functional components and the area defined by the vehicle body.

Abstract: Vehicle platforms, and systems, subsystems, and components thereof are described. A self-contained vehicle platform or chassis incorporating substantially all of the functional systems, subsystems and components (e.g., mechanical, electrical, structural, etc.) necessary for an operative vehicle. Functional components may include at least energy storage/conversion, propulsion, suspension and wheels, steering, crash protection, and braking systems. Functional components are standardized such that vehicle platforms may be interconnected with a variety of vehicle body designs (also referred to in the art as “top hats”) with minimal or no modification to the functional linkages (e.g., mechanical, structural, electrical, etc.) therebetween. Configurations of functional components are incorporated within the vehicle platform such that there is minimal or no physical overlap between the functional components and the area defined by the vehicle body.

Abstract: Methods, systems, and computer-readable media for analysis of role reachability with transitive tags are disclosed. An access control analyzer determines a graph including nodes and edges. The nodes represent roles in a provider network hosting resources. The roles are associated with access control policies granting or denying access to individual resources. One or more of the access control policies grant or deny access based (at least in part) on key-value attributes. The access control analyzer determines, based (at least in part) on a role reachability analysis of the graph, whether a first role can assume a second role using role assumption steps for a particular state of the attributes. The attributes may include transitive attributes that persist during the role assumption steps.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Abstract: Apparatus and methods for manufacturing compostable, biodegradable drink straws from polyhydroxyalkanoate (PHA) material are disclosed herein. Such apparatus may include a hopper that contains raw PHA material, an extruder that receives the raw PHA material from the hopper and produces extruded PHA material, one or more waters baths that cool the extruded PHA material, a puller that pulls a tubular stream of PHA material through the system, and a cutter that is configured to cut the stream of PHA material into finished straws. A vision system may be provided to monitor a diameter and material thickness of the cooled PHA material. The finished straws may be soil- and marine-biodegradable, as well as home- and industrial-compostable.

Abstract: Apparatus and methods for manufacturing compostable, biodegradable drink straws from polyhydroxyalkanoate (PHA) material are disclosed herein. Such apparatus may include a hopper that contains raw PHA material, an extruder that receives the raw PHA material from the hopper and produces extruded PHA material, one or more waters baths that cool the extruded PHA material, a puller that pulls a tubular stream of PHA material through the system, and a cutter that is configured to cut the stream of PHA material into finished straws. The finished straws may be soil-and marine-biodegradable, as well as home-and industrial-compostable.

Abstract: The disclosure provides an isolated canine antibody or antigen-binding portion thereof which binds to an epitope of the extracellular domain of canine PD-1, compositions comprising the same and methods of their use.

Abstract: Apparatus and methods for manufacturing compostable, biodegradable drink straws from polyhydroxyalkanoate (PHA) material are disclosed herein. Such apparatus may include a hopper that contains raw PHA material, an extruder that receives the raw PHA material from the hopper and produces extruded PHA material, one or more waters baths that cool the extruded PHA material, a puller that pulls a tubular stream of PHA material through the system, and a cutter that is configured to cut the stream of PHA material into finished straws. The finished straws may be soil- and marine-biodegradable, as well as home- and industrial-compostable.

Abstract: An access door may include a core, first and second stiles defined along opposites sides of the core such that the core between the first and second stiles defines a recessed pocket with each of the first and second stiles defining a channel therein extending longitudinally along an inwardly-facing edge thereof, bottom and top elongated panels each defining tongue members at opposite sides thereof and configured to be received transversely in the recessed pocket with the tongue members received within the channels defined along the inwardly-facing edges of the first and second stiles, wherein, with the top and bottom elongated panels received in the recessed pocket, exterior faces of the first and second stiles, exterior faces of the top and bottom elongated panels, and an exposed surface of the recessed pocket between the top and bottom elongated panels define an exterior surface of one side of the door.

Abstract: An output-amplifier-based reciprocal quantum logic (RQL) bias-level sensor is used to measure and/or calibrate bias parameters of AC and/or DC bias signals provided to RQL circuitry. The bias signals can include an output amplifier output bias current. The bias-level sensor includes a stack of DC SQUIDs that are supplied their inputs from outputs of respective Josephson transmission lines (JTLs) to which the SQUIDs are transformer-coupled. Staging relative strengths of the bias taps of the JTLs, or the critical currents of the Josephson junctions in the DC SQUIDs, allows an output voltage signal of the bias-level sensor to be indicative of whether a provided bias value is an improvement or optimization of the bias value when varied over a range. The outputs of two such bias-level sensors driven by I and Q clocks can be compared to adjust AC bias amplitudes of the clocks. Relative clock phase can be similarly adjusted.

Abstract: A vehicle imaging station for imaging a vehicle including a structured light source having a first panel portion and a second panel portion. The first panel portion is spaced from the second panel portion to define a structured lighting space between them. The structured lighting space has a central axis and being sized to enable a vehicle to be driven along the central axis through the structured lighting space from an entry plane to an exit plane. The first panel portion and the second panel portion each face the structured lighting space to project a structured light pattern into the structured lighting space. The station has a first camera mounted adjacent to a side of the first panel portion closest to the entry plane on a first side of the central axis and being orientated to face the exit plane on a second side of the central axis.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR expression and methods of using these splice-switching oligonucleotides to treat cancer, specifically castrate resistant prostate cancer.

Abstract: Methods, systems, and computer-readable media for analysis of role reachability with transitive tags are disclosed. An access control analyzer determines a graph including nodes and edges. The nodes represent roles in a provider network hosting resources. The roles are associated with access control policies granting or denying access to individual resources. One or more of the access control policies grant or deny access based (at least in part) on key-value attributes. The access control analyzer determines, based (at least in part) on a role reachability analysis of the graph, whether a first role can assume a second role using role assumption steps for a particular state of the attributes. The attributes may include transitive attributes that persist during the role assumption steps.

Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore: (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

Abstract: A downhole optical communications system provided at a downhole location in use, the downhole communications system being for communicating between the downhole location and an uphole location, such as a surface location. The downhole optical communications system comprises a downhole optical transmitter configured to emit an optical signal for transmission over an optical transmission channel between the uphole location and the downhole optical transmitter; wherein the downhole optical transmitter is configured so as to produce a response to an optical signal received from the optical transmission channel and the downhole optical communications system is configured to determine data represented by the received optical signal from the response produced by the downhole optical transmitter.

Abstract: A rotor blade retention assembly includes a central hub, a rotor blade including an upper outer surface, a lower outer surface, a blade hole, and a proximal end coupled to the central hub, a strap member extending along a portion of the rotor blade such that a distal end receiving portion extends into the blade hole, and a retainer assembly disposed within the blade hole and coupled to the strap member. The retainer assembly includes an upper bushing and a lower bushing slidably disposed within the blade hole. The upper bushing includes a counterbored portion. The retainer assembly also includes an outboard blade pin disposed within the distal end receiving portion and includes a blade pin inner cavity.