Patents by Inventor Daniel-Henri Caignard

Daniel-Henri Caignard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6759406
    Abstract: Compounds of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R1, R2 and R3 represent an alkyl group, or R1, R2 and R3, together with the nitrogen atom carrying them, form a heterocycle, X represents a (C1-C6)alkylene chain in which one or more —CH2— groups are optionally replaced by a sulphur atom, an oxygen atom, or an —NR—, —CO—, —CO—NH—, —CO2—, —SO— or —SO2— group, n represents 0 or 1, Hal represents a halogen atom, or, R4 represents an alkyl group, Hal represents a halogen atom, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or i
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: July 6, 2004
    Assignees: Les Laboratoires Servier, INSERM
    Inventors: Jean-Claude Madelmont, Isabelle Giraud, Colette Nicolas, Jean-Claude Maurizis, Maryse Rapp, Monique Ollier, Pierre Renard, Daniel-Henri Caignard
  • Patent number: 6734196
    Abstract: The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen, a nitrogen-containing heterocycle or a group of formula (II): R6 represents hydrogen or linear or branched (C1-C6)alkyl. and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: May 11, 2004
    Assignee: Les Laboratoires Servier
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cécile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20040087638
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: October 20, 2003
    Publication date: May 6, 2004
    Inventors: Sylvain Rault, Marina Kopp, Jean-Charles Lancelot, Stephane Lemaitre, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
  • Publication number: 20040063696
    Abstract: 1 wherein: represents a single or double bond, R1 represents a hydrogen atom or a hydroxy, alkoxy, acyloxy, alkylsulphonyloxy, arylsulphonyloxy or arylalkoxy group, R2 represents a hydrogen atom or an alkyl group, R3 and R4, which may be identical or different, each represent a hydrogen atom, a halogen atom or an alkyl, hydroxy or alkoxy group, Ak represents an alkylene chain, R5, R6 and R7, which may be identical or different, each represent an alkyl group, or R5, R6 and R7, taken together with the nitrogen atom carrying them, form a saturated or unsaturated nitrogen-containing heterocycle,
    Type: Application
    Filed: June 20, 2003
    Publication date: April 1, 2004
    Inventors: Jean-Claude Madelmont, Isabelle Giraud, Aurelien Vidal, Emmanuelle Mounetou, Maryse Rapp, Jean-Claude Maurizis, Pierre Renard, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard
  • Patent number: 6686378
    Abstract: Compound of formula (I): wherein: Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl, A represents a bond or linear or branched (C1-C6)alkylene, its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: February 3, 2004
    Assignee: Les Laboratoires Servier
    Inventors: Muriel Duflos, Jean-Michel Robert, Marie-Renée Nourrisson, Guillaume Le Baut, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
  • Patent number: 6638946
    Abstract: The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen, a nitrogen-containing heterocycle or a group of formula (II): R6 represents hydrogen or linear or branched (C1-C6)alkyl. and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: October 28, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cécile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20030181484
    Abstract: The invention relates to a compound of formula (I): 1
    Type: Application
    Filed: March 3, 2003
    Publication date: September 25, 2003
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cecile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20030139408
    Abstract: The invention relates to a compound of formula (I): 1
    Type: Application
    Filed: November 27, 2002
    Publication date: July 24, 2003
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cecile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 6511992
    Abstract: The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen, a nitrogen-containing heterocycle or a group of formula (II) R6 represents hydrogen or linear or branched (C1-C6)alkyl; and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: January 28, 2003
    Assignee: les Laboratories Servier
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cécile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20030013742
    Abstract: Compound of formula (I): 1
    Type: Application
    Filed: June 21, 2002
    Publication date: January 16, 2003
    Inventors: Muriel Duflos, Jean-Michel Robert, Marie-Renee Nourrisson, Guillaume Le Baut, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, Pierre Renard
  • Publication number: 20020040036
    Abstract: The invention relates to a compound of formula (I): 1
    Type: Application
    Filed: September 25, 2001
    Publication date: April 4, 2002
    Applicant: ADIR ET COMPAGNIE
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cecile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20020035123
    Abstract: The invention relates to a compound of formula (I): 1
    Type: Application
    Filed: September 25, 2001
    Publication date: March 21, 2002
    Applicant: ADIR ET COMPAGNIE
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cecile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 6323220
    Abstract: The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen, a nitrogen-containing heterocycle or a group of R6 represents hydrogen or linear or branched (C1-C6)alkyl. and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: November 27, 2001
    Assignee: Adir et Compagnie
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cécile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 6271247
    Abstract: Compounds of formula (I): R—NH—A—CO—NH—NH—(W)n—Z   (I) wherein: n is 0 or 1, W represents —CO— or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substituted, R represents a grouping selected from: Z1—T—CO—, Z1—O—T—CO—, Z1—T—O—CO—, Z1—T—S(O)q— wherein Z1, T and q are as defined in the description, A represents alkylene, alkenylene or alkynylene each having from 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene a grouping wherein B1 is as defined in the description, or A forms with the adjacent nitrogen atom a grouping as defined in the description. Medicinal products containing the same are useful as Neuropeptide Y receptors ligands.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: August 7, 2001
    Assignee: Adir et Compagnie
    Inventors: Antonio Monge Vega, Ignacio Aldana Moraza, Daniel-Henri Caignard, Jacques Duhault, Jean Boutin, Odile Dellazuana
  • Patent number: 6172108
    Abstract: Compounds of formula (I): R—NH—A—CO—NH—NH—(W)n—Z  (I) wherein: n is 0 or 1, W represents —CO— or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substituted, R represents a grouping selected from: Z1—T—CO—, Z1—O—T—CO—, Z1—T—O—CO—, Z1—T—S(O)q— wherein Z1, T and q are as defined in the description, A represents alkylene, alkenylene or alkynylene each having from 3 to 8 carbon atoms, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene a grouping wherein B1 is as defined in the description, or A forms with the adjacent nitrogen atom a grouping as defined in the description, and medicinal products containing the same which are useful as Neuropeptide Y receptor
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: January 9, 2001
    Assignee: Adir et Compagnie
    Inventors: Antonio Monge Vega, Ignacio Aldana Moraza, Daniel-Henri Caignard, Jacques Duhault, Jean Boutin, Odile Dellazuana
  • Patent number: 6071945
    Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,R.sub.2 represents optionally substituted aryl or heteroaryl,R.sub.3 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,their isomers and addition pharmaceutically-acceptable acid or base salts thereof and medicinal products containing the same are useful in the treatment of cancer.
    Type: Grant
    Filed: July 26, 1999
    Date of Patent: June 6, 2000
    Assignee: Adir et Compagnie
    Inventors: Sylvain Rault, Cecile Enguehard, Jean-Charles Lancelot, Max Robba, Ghanem Atassi, Alain Pierre, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 6063816
    Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle,R.sub.2 represents alkylene,R.sub.3 represents X or Y as defined in the description,R.sub.4 represents--either alkyl, cycloalkyl, aryl, arylalkyl, cycloalkylalkyl, heterocycloalkylene, or heterocycle when R.sub.3 represents Y,or biaryl, arylheteroaryl or heteroarylaryl, when R.sub.3 represents X or Y,their isomers and also pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as metalloprotease inhibitors in the treatment of cancers.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: May 16, 2000
    Assignee: Adir et Compagnie
    Inventors: Stephen Hanessian, Ghanem Atassi, Gordon Tucker, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 5925665
    Abstract: Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: July 20, 1999
    Assignee: Adir Et Compagnie
    Inventors: Marc Payard, Saadia Danoun, Genevieve Baziard-Mouysset, Maria Anastassiadou, Daniel-Henri Caignard, Pierre Renard, Dominique Manechez, Elizabeth Scalbert, Marie-Claire Rettori
  • Patent number: 5919784
    Abstract: A compound of general formula (I): ##STR1## where A, X, R.sub.1, Y, n and Ar are defined in the description. Medicinal products containing the same are useful as D.sub.4 receptor Ligands.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: July 6, 1999
    Assignee: Adir Et Compagnie
    Inventors: Daniel Lesieur, Pascal Carato, Jean-Paul Bonte, Patrick Depreux, Daniel-Henri Caignard, Mark Millan, Adrian Newman-Tancredi, Pierre Renard, Marie-Claire Rettori
  • Patent number: 5889045
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents alkyl,R.sub.2, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen or alkyl,R.sub.3 represents any one of the groups as defined in the description,X represents carbonyl or methylene,Y represents hydrogen or alkyl or aryl,A represents single bond or alkylphenyl,R.sub.6 represents any one of the groups as defined in the description, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal productes containing the same are useful in the treatment of diabetes and complications of diabetic disease.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 30, 1999
    Assignee: Adir et Compagnie
    Inventors: Timothee Muller, Claudie Moulin, Muriel Duflos, Sylvie Robert-Piessard, Guillaume Le Baut, Alain Tonnerre, Daniel-Henri Caignard, Dominique Manechez, Pierre Renard