Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.

Abstract: New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Abstract: New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Abstract: New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

Abstract: Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein

Abstract: New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Abstract: A medically implantable electrical connector includes a housing having a bore with an internal V-groove or a flat bottom groove therein along with radial garter spring disposed in the V-groove or an axial garter spring disposed in the flat bottom groove. A pin is provided and sized for insertion in the housing bore. The housing, spring and pin are formed from a combination of medically implantable materials in order to control electrical resistivity between the housing, the garter spring and the pin.

Abstract: A medically implantable electrical connector includes a housing having a bore with an internal V-groove or a flat bottom groove therein along with radial garter spring disposed in the V-groove or an axial garter spring disposed in the flat bottom groove. A pin is provided and sized for insertion in the housing bore. The housing, spring and pin are formed from a combination of medically implantable materials in order to control electrical resistivity between the housing, the garter spring and the pin.

Abstract: A spring energized connector includes an axial spring ring disposed within a housing having a bore with an internal groove for retaining the spring. A piston is provided having an external groove for receiving a portion of this spring and a chamfer is provided for radially expanding the spring as the piston is inserted into the bore in a connect direction with a selected connect force. A contact retaining wall, defining an internal groove sidewall, is disposed at an angle from a normal to a bore centerline for causing axial compression of the spring as the piston is moved in a disconnect direction, opposite the connect direction, causing a disconnect force, in the disconnect direction, greater than a connected force.