Abstract: A syringe and a reconstitution syringe are provided for the delivery of controlled doses of any of numerous different sterile substances, such as vaccines, medicaments, pharmaceutical preparations, cosmetics, and food products. A plunger of the syringe defines a resealable stopper frictionally and slidably received within a hollow syringe body for dispensing the medicament or other substance through a dispensing tip of the syringe upon movement of the plunger. The resealable stopper defines a heat-sealable portion to allow the stopper to be penetrated by a needle or other filling device to fill the syringe with a medicament or other substance, and in turn allow the hole remaining upon withdrawal of the needle to be heat sealed by transmission of laser energy thereon.

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol.

Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser, without requiring the use of preservatives. The one-way actuation mechanism enables the user to load and dispense a uniform quantity of medicament with a uniform actuation force and speed via a single continuous motion of the actuation mechanism. The rigid vial/expandable-pouch combination facilitates improved long term use, as well as uniformity of dosage independent of the pump orientation.

Abstract: A contact lens applicator has an elongated housing defining an interior chamber for storing contact lenses, first and second triggers mounted on the housing, a depressor for depressing each eyelid where the depressor is drivingly coupled to the triggers, a pair of opposing wing-shaped members projecting outwardly from opposite sides of the rollers for providing a support surface for facilitating locating the apparatus over the eye, and a pusher assembly slidably mounted within the interior chamber for engaging a contact lens holder and applying a contact lens thereon to the eye when the triggers are actuated. The contact lens is stored in a cartridge within the elongated housing. The lens holder is movable within the cartridge upon actuating the pusher, and includes a predetermined amount of saline or other solution for defining appropriate conditions for storing the lens.

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

Abstract: A resealable cap for a medicament vial has a base portion formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion overlying the base portion. The resealable portion is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member for dispensing medicament into the vial. Prior to filling, the cap is assembled to the vial and the cap/vial assembly is sterilized. Then, a needle is inserted through the cap and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle, the penetrated region of the cap is fused by laser or direct heat sealing to hermetically seal the needle hole in the cap.

Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The nasal screen aligns the dispenser nozzle with the nasal passage and also allows the user to discreetly hide the nasal area from public view. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser regardless of the environment surrounding the dispenser, without requiring the use of preservatives.

Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The nasal screen aligns the dispenser nozzle with the nasal passage and also allows the user to discreetly hide the nasal area from public view. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser regardless of the environment surrounding the dispenser, without requiring the use of preservatives.

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.

Abstract: A nozzle mechanism for generating an aerosol-type liquid discharge is provided, which nozzle mechanism ensures one-way movement of liquid during discharge and also has a substantially zero "dead volume" at the tip of the nozzle. The nozzle mechanism includes a flexible nozzle portion with an outlet and a fluid channel, a rigid shaft received within the flexible nozzle portion, and a rigid housing surrounding the flexible nozzle portion and exposing the outlet. The rigid shaft interfaces the outlet to form a first normally-closed, one-way valve, as well as to define a swirling chamber for collecting the liquid which has been channeled from the liquid reservoir, prior to being discharged via the outlet. The outlet has a tubular wall with thickness that decreases along the elongated axis of symmetry for the outlet toward the tip of the outlet. The fluid channel is circumferentially positioned within the flexible nozzle portion to create swirling action of the liquid delivered to said swirling chamber.

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament.

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract: A double-dispenser system for dispensing medicinal liquids has two jet-trigger pumps housed in an outer casing having at least one front opening and one rear opening. Each jet-trigger pump is provided with a dosing mechanism for dispensing a predetermined dose of medicinal liquid. Dispensation from the two pumps may be triggered simultaneously by a trigger device common to the two pumps and accessible from the outside of the casing. The pumps incorporated in the double-dispenser system may be of the type having a pump body and a piston housed in an elastic bottle. For each pump, relative movements between the piston and the pump body causes changes in the relative-displacement between the piston and the pump body such that medicinal liquid is initially loaded into a medicine-holding cavity within the pump and subsequently dispensed.

Abstract: A nozzle mechanism for generating an aerosol-type liquid discharge is provided, which nozzle mechanism ensures one-way movement of liquid during discharge and also has a substantially zero "dead volume" at the tip of the nozzle. The nozzle mechanism includes a flexible nozzle portion with an outlet and a fluid channel, a rigid shaft received within the flexible nozzle portion, and a rigid housing surrounding the flexible nozzle portion and exposing the outlet. The rigid shaft interfaces the outlet to form a first normally-closed, one-way valve, as well as to define a swirling chamber for collecting the liquid which has been channeled from the liquid reservoir, prior to being discharged via the outlet. The outlet has a tubular wall with thickness that decreases along the elongated axis of symmetry for the outlet toward the tip of the outlet. The fluid channel is circumferentially positioned within the flexible nozzle portion to create swirling action of the liquid delivered to the swirling chamber.

Abstract: Method of transferring articles (1) contained in a closed transfer pocket (4) into an enclosure, wherein a part S of the wall of the closed transfer pocket (4) is stuck onto a part of the enclosure, there is cut out in the said part S, and from the inside of the enclosure, an opening of sufficient area to allow the passage of the said articles (1), the periphery of the opening of the transfer pocket (4) remaining stuck to the enclosure, and a corresponding opening (13) is made in the enclosure and the said articles (1) are then transferred into the enclosure through the said openings, pocket and enclosure for sterile transfer in particular.

Abstract: A pump for delivering a fluid contained in an elastic phial includes a pump body and a movable piston fitted inside the pump body. The front end of the pump body is located on a fluid-outlet side, and the front end includes an outlet orifice (11) sealed off by an elastic membrane (24). The outlet orifice is connected to a pump duct (18) inside the pump body, and the pump duct 18 is in turn connected to a fluid-inlet orifice (15). An end (2) of the movable piston is hermetically fitted within the pump duct (18) with slight friction, and the displacement of the end (2) of the piston relative to the portion of the pump body between the inlet orifice (15) and the a stop position (16) near the outlet orifice (11) determines the quantity of fluid expelled from the pump body. The inlet orifice allows a predetermined quantity of fluid to be trapped at the end of the pump duct (18) before being expelled through the outlet orifice (11).

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract: An automated process for filling a sealed receptacle (1) with a fluid under aseptic conditions is disclosed. The sealed receptacle has at least one part (2B) made of a material capable of being pierced by a hollow needle (8R) and sufficiently flexible to close itself up again after removal of the hollow needle. In the automated process, the part (2B) of the sealed receptacle is pierced using a hollow filling needle (8R) which is in contact with the fluid to be channeled into the receptacle (1). During the process of filling the receptacle (1), the perforating end of the hollow filling needle (8R) is maintained under aseptic conditions by means of laminar gas flow.

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A tight interface is defined between the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The interface opens in response to the flow of medicament of sufficient pressure into it to permit the passage of medicament through the nozzle for release into the eye.

Abstract: A cartridge for actuating a piston-like or accordion-like dispenser-vial for applying medicament to an eye. The cartridge includes a housing for holding the dispenser-vial and a telescoping cylinder for compressing the dispenser-vial in the longitudinal direction to actuate the vial. The cartridge includes a locking mechanism for locking the telescoping cylinder to restrict its movement and a trigger mechanism for releasing the cylinder from the locked position so that a drop is released from the dispenser. The housing includes a finger for engaging the lower eyelid and exposing the conjunctival cul de sac.