Abstract: The present invention relates to a compound according to formula I wherein X represents NH or 0; n is an integer selected from 1-3; Y represents a bond, —C(O)O—*, —C(O)OR3—* or —C(O)NHR3—*; W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: A motion activated illuminated bracelet includes a circular shaped main body having an inside diameter that is suitable for being worn about the wrist of a user. A plurality of illuminating charms is positioned equidistantly along the main body and include a power source, a switch and a light. A plurality of audible charms is positioned equidistantly along the main body and include a power source, a switch and a speaker. A plurality of decorative charms is positioned equidistantly along the main body and include a housing having any number of decorative elements, and a weight that is complementary to the weight of an audible charm or an illuminating charm. Each of the illuminating charms and the audible charms are selectively activated by a centrifugal force associated with the rotation of the bracelet, and some of the illuminated charms are connected to the main body via a resilient tether.

Abstract: The present invention relates to a compound according to formula I wherein R1 represents alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, —SO2Ra, —SO2NRbRc, —C(O)Rb, phenyl and 5- and 6-membered heteroaryl or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: A system that creates an inventory organization within an electronic business system is provided. The system receives a request to create the inventory organization. The system further displays an electronic template within a graphical user interface, the electronic template including inventory organization fields. The system further receives attributes of the inventory organization that are input within the inventory organization fields of the electronic template. The system further validates the attributes of the inventory organization. The system further generates inventory organization data based on the attributes of the inventory organization and rules, the inventory organization data including the attributes of the inventory organization. The system further populates the inventory organization data into a database of the electronic business system.

Abstract: A motion activated illuminated bracelet includes a circular shaped main body having an inside diameter that is suitable for being worn about the wrist of a user. A plurality of illuminating charms is positioned equidistantly along the main body and include a power source, a switch and a light. A plurality of audible charms is positioned equidistantly along the main body and include a power source, a switch and a speaker. A plurality of decorative charms is positioned equidistantly along the main body and include a housing having any number of decorative elements, and a weight that is complementary to the weight of an audible charm or an illuminating charm. Each of the illuminating charms and the audible charms are selectively activated by a centrifugal force associated with the rotation of the bracelet, and some of the illuminated charms are connected to the main body via a resilient tether.

Abstract: A mobile app generates and manages companion apps in a memory of the mobile computing device. The companion apps cooperate with one or more integrated tracker apps in a memory of a wearable device to provide a combined functionality to the wearable device. A companion app communicates with an integrated tracker app to provide at least extended capabilities for the integrated tracker app including adding connectivity to the Internet to access On-line services and gather data on behalf of the integrated tracker app via the integrated tracking app submitting a request to an application programming interface for the companion app. The mobile app coordinates activities between i) multiples instances of the companion app loaded in the memory of the mobile computing device and ii) the integrated tracker apps running in the memory of the wearable device.

Abstract: A system may be configured to manage at least one robotic device. The system may comprise one or more databases and one or more processors in communication with the one or more databases. The one or more processors may be configured to provide an operating system for the at least one robotic device, control motion of the at least one robotic device, configure at least one sensor removably coupled to the at least one robotic device, process data collected by the at least one sensor, and/or perform localization and/or area mapping for the at least one robotic device by comparing data collected by the at least one sensor with data in the one or more databases to generate localization and/or area mapping data.

Abstract: Protective cooling cover which comprises a hollow shell defining a generally semi-cylindrical cavity (15) that covers a portion of a cutting disc (2) at the top and that is delimited by two lateral walls (11, 12) and a curved perimeter wall (13), a cooling device including a tube connected to a cooling liquid supply and to a cooling liquid projecting nozzle (31), and a fastening device for fixing said cooling liquid projecting nozzle at different positions within the cavity (15) of the shell for projecting cooling liquid to different areas of the cutting disc, said fastening device including a plurality of first fasteners connected to the periphery of the cavity, and a second fastener connected to the cooling liquid projecting nozzle (31), said first and second fasteners providing a snap fit releasable connection.

Abstract: Fuel nozzle assemblies are flushed after ultrasonic cleaning. In one embodiment, a method includes: cleaning a fuel nozzle assembly by ultrasonic cleaning; and after the ultrasonic cleaning, flushing the fuel nozzle assembly using a solution, the fuel nozzle assembly comprising a valve located in an interior of the fuel nozzle assembly, the solution flowing through the interior of the fuel nozzle assembly, and the flowing of the solution controlled by the valve.

Abstract: Fuel nozzle assemblies are flushed after ultrasonic cleaning. In one embodiment, a method includes: cleaning a fuel nozzle assembly by ultrasonic cleaning; and after the ultrasonic cleaning, flushing the fuel nozzle assembly using a solution, the fuel nozzle assembly comprising a valve located in an interior of the fuel nozzle assembly, the solution flowing through the interior of the fuel nozzle assembly, and the flowing of the solution controlled by the valve.

Abstract: A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal rechargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system.

Abstract: A mobile app generates and manages companion apps in a memory of the mobile computing device. The companion apps cooperate with one or more integrated tracker apps in a memory of a wearable device to provide a combined functionality to the wearable device. A companion app communicates with an integrated tracker app to provide at least extended capabilities for the integrated tracker app including adding connectivity to the Internet to access On-line services and gather data on behalf of the integrated tracker app via the integrated tracking app submitting a request to an application programming interface for the companion app. The mobile app coordinates activities between i) multiples instances of the companion app loaded in the memory of the mobile computing device and ii) the integrated tracker apps running in the memory of the wearable device.

Abstract: Embodiments may relate to intuitive user-interface features for a head-mountable device (HMD), in the context of a hybrid human and computer-automated response system. An illustrative method may involve a head-mountable device (HMD) that comprises a touchpad: (a) sending a speech-segment message to a hybrid response system, wherein the speech-segment message is indicative of a speech segment that is detected in audio data captured at the HMD, and wherein the speech-segment is associated with a first user-account with the hybrid response system, (b) receiving a response message that includes a response to the speech-segment message and an indication of a next action corresponding to the response to the speech-segment message, (c) displaying a screen interface that includes an indication of the response, and (d) while displaying the response, detecting a singular touch gesture and responsively initiating the at least one next action.

Abstract: Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that may silence the activity of a RNA-dependent DNA methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the construct comprises an exogenous nucleic acid sequence, wherein the construct renders the maternal plant defective for RNA-dependent DNA methylation.

Abstract: A system may be configured to manage at least one robotic device. The system may comprise one or more databases and one or more processors in communication with the one or more databases. The one or more processors may be configured to provide an operating system for the at least one robotic device, control motion of the at least one robotic device, configure at least one sensor removably coupled to the at least one robotic device, process data collected by the at least one sensor, and/or perform localization and/or area mapping for the at least one robotic device by comparing data collected by the at least one sensor with data in the one or more databases to generate localization and/or area mapping data.

Abstract: Protective cover with cooling for cutter discs; which comprises a generally semi-cylindrical cavity (15) that covers a portion of the cutting disc (2) at the top and that is delimited by two lateral walls (11, 12) and a curved perimeter wall (13). Said cavity (15) internally comprises, in its periphery, fastening means (16, 17) for a tube (3) and a cooling liquid supply nozzle (31) for the disc (2) in at least one upper position (P1) in which the nozzle (31) pours the liquid on the upper end of the disc (2), and one lower position (P5) in which the nozzle (31) sprays the liquid directly against the edge of the disc (2).

Abstract: Methods are described herein related to providing a workspace that is associated with a voice-request account workspace and that is capable of establishing a session for a user-account. An example method may involve: (a) providing, by a computing system, a workspace on a virtual machine, where the workspace is associated with a voice-request account, where the workspace is accessible to one or more guide computing systems, (b) receiving, at the computing system, authentication information for a user-account, (c) receiving, at the computing system, a request to establish a session for the user-account in the workspace associated with the voice-request account and responsively establishing the session, and (d) providing, by the computing system, the one or more guide accounts with access via the workspace to the session for the user-account.

Abstract: A pressure sensor module configured for implant at a desired site at which a pressure is to be measured. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. The pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.

Abstract: Embodiments may relate to intuitive user-interface features for a head-mountable device (HMD), in the context of a hybrid human and computer-automated response system. An illustrative method may involve a head-mountable device (HMD) that comprises a touchpad: (a) sending a speech-segment message to a hybrid response system, wherein the speech-segment message is indicative of a speech segment that is detected in audio data captured at the HMD, and wherein the speech-segment is associated with a first user-account with the hybrid response system, (b) receiving a response message that includes a response to the speech-segment message and an indication of a next action corresponding to the response to the speech-segment message, (c) displaying a screen interface that includes an indication of the response, and (d) while displaying the response, detecting a singular touch gesture and responsively initiating the at least one next action.