Abstract: This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited to transcriptional silencing and controlled enzyme proteolysis. These microbial strains are utilized in a multi-stage bioprocess encompassing at least two stages, the first stage in which microorganisms are grown and metabolism can be optimized for microbial growth and at least one other stage in which growth can be slowed or stopped, and dynamic changes can be made to metabolism to improve the production of desired product, such as a chemical or fuel.

Abstract: A method is provided for detection of a ground fault in a high resistance network in a voltage source power conversion circuit comprising a power converter that converts incoming AC power to DC power applied to a DC bus and an inverter that converts DC power from the DC bus to output AC power. The method includes detecting a midpoint-to-ground voltage between a low side of the DC bus and a ground potential and detecting the presence of a ground fault in a high resistance network based upon the detected midpoint-to-ground voltage.

Abstract: Embodiments may relate to intuitive user-interface features for a head-mountable device (HMD), in the context of a hybrid human and computer-automated response system. An illustrative method may involve a head-mountable device (HMD) that comprises a touchpad: (a) sending a speech-segment message to a hybrid response system, wherein the speech-segment message is indicative of a speech segment that is detected in audio data captured at the HMD, and wherein the speech-segment is associated with a first user-account with the hybrid response system, (b) receiving a response message that includes a response to the speech-segment message and an indication of a next action corresponding to the response to the speech-segment message, (c) displaying a card interface that includes an indication of the response, and (d) while displaying the response, detecting a singular touch gesture and responsively initiating the at least one next action.

Abstract: Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that can silence the activity of a RNA-dependent DNA methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the construct comprises an exogenous nucleic acid sequence, wherein the construct renders the maternal plant defective for RNA-dependent DNA methylation.

Abstract: The invention relates to compounds of general formula (I) wherein A, R1, R2, R3, R4, R5, R9, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immunosuppression would be desirable for example in organ transplantation.

Abstract: A system that creates an inventory organization within an electronic business system is provided. The system receives a request to create the inventory organization. The system further displays an electronic template within a graphical user interface, the electronic template including inventory organization fields. The system further receives attributes of the inventory organization that are input within the inventory organization fields of the electronic template. The system further validates the attributes of the inventory organization. The system further generates inventory organization data based on the attributes of the inventory organization and rules, the inventory organization data including the attributes of the inventory organization. The system further populates the inventory organization data into a database of the electronic business system.

Abstract: The invention relates to compounds of general Formula (I), Wherein R1, R2, R3, R4, R5, m, n are defined herein, and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immunosuppression would be desirable for example in organ transplantation.

Abstract: A procedure applicable in a dental implant with at least one outer surface made of titanium or titanium alloy includes a prior preparation of the external surface of the implant, including at least one of the following operations: roughing, polishing, cleaning, decontamination and/or elimination of a layer of titanium oxide from said outer surface of the implant; and the deposit of particles of silver on an outer surface of the implant, made of titanium or titanium alloy, through a pulsed current electrochemical anodization process. The obtained dental implant with antibacterial protection is also disclosed.

Abstract: A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal rechargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system.

Abstract: A method is provided for detection of a ground fault in a high resistance network in a voltage source power conversion circuit comprising a power converter that converts incoming AC power to DC power applied to a DC bus and an inverter that converts DC power from the DC bus to output AC power. The method includes detecting a midpoint-to-ground voltage between a low side of the DC bus and a ground potential and detecting the presence of a ground fault in a high resistance network based upon the detected midpoint-to-ground voltage.

Abstract: A method is provided for detection of a ground fault in a high resistance network in a voltage source power conversion circuit comprising a power converter that converts incoming AC power to DC power applied to a DC bus and an inverter that converts DC power from the DC bus to output AC power. The method includes detecting a midpoint-to-ground voltage between a low side of the DC bus and a ground potential and detecting the presence of a ground fault in a high resistance network based upon the detected midpoint-to-ground voltage.

Abstract: This invention provides, among other things, a compact apparatus for transporting life support systems. In certain embodiments, the apparatus comprises a frame that is adapted to receive one or more components of a life-support system. Optionally, the frame may be configured such that it can be detachably secured to a transportable support member.

Abstract: Methods and systems for tracking an electronic signal corresponding to an operating frequency of an electronic component are provided. A method may include sampling the signal to determine previous and current time samples of the signal. A frequency of interest in the signal may also be pre-warped to decrease adverse warping effects resulting from processing signals having relatively higher operating frequencies. The previous and current time samples of the signals, along with the pre-warped frequency of interest, may be input into a digital tracking filter. The digital tracking filter may be configured to execute one or more algorithms on the previous and current time samples and the pre-warped frequency of interest to estimate a current operating frequency.

Abstract: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.

Abstract: Various embodiments are disclosed relating to a memory circuit architecture. In an example embodiment, which may accommodate a change to a new memory size or cell aspect ratio, while migrating between different process nodes or the same process generation, while retaining at least a portion of the periphery circuitry, a memory circuit architecture may be employed in which the memory array is divided into an upper half and a lower half, thereby splitting the cache Ways among the two halves. The wordline may be split among the two array halves, with each half driven by a half wordline driver. Also, in another embodiment, two sets of bitlines may be provided for each column, including a contacted set of bitlines and a feed-through set of bitlines.

Abstract: The invention relates to compounds of general formula (I) wherein A, R1, R2, R3, R4, R5, R9, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immunosuppression would be desirable for example in organ transplantation.

Abstract: A method is provided for detection of a ground fault in a high resistance network in a voltage source power conversion circuit comprising a power converter that converts incoming AC power to DC power applied to a DC bus and an inverter that converts DC power from the DC bus to output AC power. The method includes detecting a midpoint-to-ground voltage between a low side of the DC bus and a ground potential and detecting the presence of a ground fault in a high resistance network based upon the detected midpoint-to-ground voltage.

Abstract: A method of fabricating a two-layer phase mask comprises subjecting a photoresist material to two overlapping laser beams that create light and dark fringes in the overlapping beam regions. The photoresist can comprise a liquid crystal and a photo-sensitive material, including, for example, a photo-sensitive monomer and/or polymer. The two laser beams can be first directed towards one side of the photoresist. In the areas subjected to lighter fringes, the polymer molecules can link together and force the liquid crystal into the areas subjected to the darker fringes. This can leave an alternating pattern of linear strips of polymer-rich and liquid crystal-rich regions. The exposure time can be limited so that the strips are formed only partially through the thickness of the photoresist. The photoresist can be then rotated 90 degrees and the overlapping laser beams directed towards the opposite side of the photoresist.

Abstract: Methods and systems for synchronizing an electric grid having unbalanced voltages are provided. Voltage vectors may be synchronized in a phase-locked-loop configured to maintain synchronous operation of the grid even when the voltages are unbalanced. For example, a phase-locked-loop may be coupled to one or more tracking filters designed to estimate a disturbance in an error signal of the voltages. The estimated disturbance(s) may be removed from the error signal before the phase lock loop determines an estimate of the grid frequency. Thus, adverse affects of voltage unbalance, such as abnormal current behavior, may be mitigated.

Abstract: Methods and systems for tracking an electronic signal corresponding to an operating frequency of an electronic component are provided. A method may include sampling the signal to determine previous and current time samples of the signal. A frequency of interest in the signal may also be pre-warped to decrease adverse warping effects resulting from processing signals having relatively higher operating frequencies. The previous and current time samples of the signals, along with the pre-warped frequency of interest, may be input into a digital tracking filter. The digital tracking filter may be configured to execute one or more algorithms on the previous and current time samples and the pre-warped frequency of interest to estimate a current operating frequency.