Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

Abstract: Exemplary embodiments relate to techniques for applying media effects to a video stream. For example, media effects may be applied and/or altered based on input from viewers or participants in the video stream. Changes to the media effects may accumulate based on the inputs. In another example, viewership numbers or engagement with a user applying a media effect may alter the media effect. In a broadcast context, actions of the broadcast audience (e.g., as measured by polling) may affect the broadcast and hence the broadcaster. Object recognition and/or people recognition may be applied to cumulatively alter the media effects in an augmented reality context.

Abstract: Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place.

Abstract: A semiconductor package includes a leadframe, a first transistor chip connected to a first island of the leadframe in a drain-down configuration, and a second transistor chip connected to a second island of the leadframe in the same drain-down configuration as the first transistor chip. The first and the second islands of the leadframe are mutually electrically isolated from one another. The first island includes an extension which extends beyond a perimeter of the first transistor chip in a direction towards the second island and overlaps the second transistor chip. The first transistor chip and the second transistor chip are electrically interconnected with one another via the extension of the first island and a first electric connection element electrically connecting the extension to the second transistor chip to form a half bridge circuit.

Abstract: Certain exemplary embodiments relate to entertainment systems and, more particularly, to systems that incorporate digital downloading jukebox features and improved user interfaces. For instance, a smart search may be provided, e.g., where search results vary based on the popularity of songs within the venue, in dependence on songs being promoted, etc. As another example, a tile-based approach to organizing groupings of songs is provided. Groupings may involve self-populating collections of songs that combine centrally-promoted songs, songs in a given genre that are popular across an audiovisual distribution network, and songs that are locally popular and match up with the given genre (e.g., because of shared attributes such as same or similar genre, artist, etc.). Different tile visual presentations also are contemplated, as are different physical jukebox designs. In certain example embodiments, a sealed core unit with the “brains” of the jukebox is insertable into a docking station.

Abstract: A technological solution to the problem of meeting people solely through electronic communication is described. The technological solution includes receiving location data from a first user system a second user system of a potential encounter within a venue, and delivering a nudge from the first user system to the second user system. The nudge is a canned request to engage in an in-person communication for users associated with the first user system and the second user system. Upon confirmation of the nudge, and receiving confirmation of a human-to-human interaction, potential encounter contact information is provided to facilitate electronic communication between the first user system and the second user system.

Abstract: A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.

Abstract: The present disclosure provides a portable drug dispenser which includes one or more chambers for holding a plurality of separately contained drug products, a dispensing mechanism for accurately dispensing one or more of the plurality of separately contained drugs upon activation of the dispensing mechanism in a specified dose (e.g. specified volume/number of drops) at specified times, and a processor configured to determine the time, and potentially other information such as, e.g. location, patient variables, user data input of each activation of the dispensing mechanism, and an ability to transmit the determined time of activation to a computer located remote to the dispenser, optionally stored on the device as well for read out by a clinician managing the patient.

Abstract: A system for detecting an attack by a virtual or physical machine on one or more auto-generated websites is provided. The system includes a processor, a memory, and an application. The application is stored in the memory and includes instructions, which are executable by the processor. The instructions are configured to: access an index of a search engine server computer and determine uniform resource locators (URLs) of auto-generated websites, where the auto-generated websites include the one or more auto-generated websites; and access Internet protocol (IP) address-URL entries stored in a domain name system server computer.

Abstract: A method for loading an assembly for a CAx client includes determining referenced part IDs referenced by the assembly and for each referenced part ID, determining a latest applied command of saved checkpoints for each part file of a referenced part ID. The method further includes determining any unapplied commands for each referenced part ID, loading the part file for each referenced part ID with the latest applied command to the CAx client, and applying the unapplied commands sequentially by command number. A computer program product such as a computer readable medium and a computer system corresponding to the above method are also disclosed herein.

Abstract: This disclosure relates to a system and method for determining vehicle operator preparedness for vehicles that support both autonomous operation and manual operation. The system includes sensors configured to generate output signals conveying information related to vehicles and their operation. During autonomous vehicle operation, the system gauges the level of responsiveness of an individual vehicle operator through challenges and corresponding responses. Based on the level of responsiveness, a preparedness metric is determined for each vehicle operator individually.

Abstract: An inhalant material container for electronic smoking device is a tube-like storage container with an open top and an open bottom. The container is made of quartz, glass, or other like materials. The container has a frangible seal covering the open top and open bottom and may have exterior channels to promote air flow around the container. The container is removably inserted into the heating chamber of an electronic smoking device. The container is easily removed and replaced for on demand use. The container can be used in conjunction with modular electronic cigarettes and vaporizer and their various components and connectors.

Abstract: An apparatus according to one embodiment includes a door closer having a pinion adapted to be operably coupled to a door and rotate in a first direction in response to opening the door and to rotate in a second direction in response to closing the door, and a power boost module operably coupled to the pinion. The power boost module includes a motor adapted to generate electrical energy via rotational movement of the pinion and supply a boost force to the pinion to assist closing the door, a gearing operably coupled to the pinion and the motor and structured to back drive the motor to generate the electrical energy in response to rotation of the pinion, and an energy storage device adapted to store the electrical energy generated by the motor and supply stored electrical energy to the motor for the boost force.

Abstract: An apparatus is described which introduces cryogenic particles received from a source of particles, having a first pressure, into a moving transport fluid, having a second pressure, for ultimate delivery to a workpiece or target as particles entrained in a transport fluid flow which seals between the source of particles and the transport fluid flow.

Abstract: Surgical devices and methods are described. The surgical devices can generally include a housing having one or more actuators such as a closure actuator. An elongate shaft can extend distally from the housing and an end effector can be selectively coupled to a distal end of the shaft. The surgical device can include various features that prevent a user from actuating the device when the end effector is not properly coupled to the shaft. More specifically, the housing can include a locking member that can be pivoted or otherwise move relative the housing to cause various internal features of the housing to move to a ready-to-load position. With the locking member and actuator so positioned, an end effector can be loaded onto the shaft and the locking member can be moved from the ready-to-load position to the ready-to-actuate position, thus allowing the closure actuator to be in a ready-to-actuate position.

Abstract: In accordance with an embodiment, a radio frequency (RF) amplifier circuit includes a switchable capacitance circuit having a first terminal configured to be coupled to an input matching inductor. The switchable capacitance circuit is configured to provide a short circuit between the first and second terminals in a first state, and provide a first capacitive impedance between the first and second terminals in a second state. The RF amplifier also includes a low noise amplifier (LNA) having an input terminal coupled to the second terminal of the switchable capacitance circuit; and a bypass switch coupled to an output of the LNA, the second terminal of the switchable capacitance circuit, and an output of the RF amplifier circuit. The bypass switch is configured to select the output of LNA in the first state, and select the second terminal of the switchable capacitance circuit in the second state.

Abstract: Systems and methods for controlling supply of electrical energy from power source(s) through a plurality of electrical conductors adjacent to a common electrolyte solution are disclosed. The power source(s) are controlled to apply potential difference waveform(s) between pairs of electrical conductors formed from the plurality of electrical conductors such that the potential difference waveform(s) have a magnitude that exceeds a threshold overpotential for the pairs of electrical conductors in the electrolyte solution while sums of an absolute value of a potential difference across a double layer associated with the first electrical conductor in a pair and an absolute value of a potential difference across a double layer associated with a second electrical conductor in the pair is maintained below the threshold overpotential. Some or all electrical conductor(s) can be coupled to the power source(s) using respective capacitor(s).

Abstract: A solenoid actuator is provided that includes a casing. A coil is positioned within the casing. A flux tube and axially separated pole piece are encircled by the coil. An armature is slidably mounted within bores of the flux tube and pole piece. The flux tube and pole piece are separated by a flux choke. A core shunt juxtaposes the pole piece from the flux choke. The core shunt, on major cross-sectional tubular thickness and a minor cross-sectional tubular thickness has an outer diameter of a curved shunt to provide enhanced performance stability.

Abstract: Systems, methods, apparatuses, and software for measuring and determining physiological parameters of a patient are presented. In one example, a physiological measurement system includes an optical system configured to emit one or more optical signals into tissue of a patient, and detect the one or more optical signals after propagation through the tissue. The physiological measurement system includes a capacitance system configured to apply one or more electric field signals to a single side of the tissue to determine a capacitance signal based at least on changes in the one or more electric field signals, and a processing system configured to process at least the one or more detected optical signals and the capacitance signal to determine a physiological parameter of the patient.