Abstract: Systems and methods are provided for predicting metastasis of a cancer in a subject. A plurality of data elements for the subject's cancer is obtained, including sequence features comprising relative abundance values for gene expression in a cancer biopsy of the subject, optional personal characteristics about the subject, and optional clinical features related to the stage, histopathological grade, diagnosis, symptom, comorbidity, and/or treatment of the cancer in the subject, and/or a temporal element associated therewith. One or more models are applied to the plurality of data elements, determining one or more indications of whether the cancer will metastasize. A clinical report comprising the one or more indications is generated.

Abstract: Systems, methods and apparatus for spectrum data management for a radio frequency (RF) environment are disclosed. An apparatus comprises at least one receiver, an automatic signal detection (ASD) module, and a learning and conflict detection engine. The apparatus is at the edge of a communication network. The at least one receiver processes RF energy received from the RF environment, thereby generating processed data. The ASD module is configured to extract meta data and detect anomaly based on the processed data. The learning and conflict detection engine is configured for conflict recognition and anomaly identification based on the processed data. The apparatus is operable to generate at least one report for the RF environment.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample.

Abstract: A child transport carrier includes a lower frame, an upper frame, a rear frame, and a first upper seat support. The lower frame includes a first end and a second end. The upper frame includes a first end and a second end. The rear frame extends from the second end of the lower frame to the second end of the upper frame. The first upper seat support includes a cross-member extending transversely across the first upper seat support and having a first end and a second end. The cross-member is configured to move the first upper seat support between a first seat position and a second seat position. The upper frame extends from an upper end of the rear frame and the lower frame extends from a lower end of the rear frame.

Abstract: A graphical classification method for classifying graphical structures, said graphical structures comprising nodes defined by feature vectors and having relations between the nodes. The method includes representing the feature vectors and relations as a first graphical representation. The method also includes mapping said first graphical representation into a second graphical representation wherein the mapping comprises using an attention mechanism, said attention mechanism establishes the importance of specific feature vectors dependent on their neighbourhood and the relations between the feature vectors, said mapping transforming the feature vectors of the first graphical representation to transformed feature vectors in the second graphical representation. The method also includes combining the transformed feature vectors to obtain a third combined representation said third combined representation being an indication of the classification of the graphical structure.

Abstract: A terminal includes a first connection section having a first connection central axis extending centrally though the first connection section along a longitudinal direction and a shoulder having a first surface extending normal to the longitudinal direction at an end of the first connection section. The shoulder has a width greater than the first connection section in a width direction perpendicular to the longitudinal direction and has a shoulder central axis extending centrally though the shoulder along the longitudinal direction. The shoulder central axis is offset from the first connection central axis in the width direction.

Abstract: The present disclosure describes a shoe that may be transformed from a high heel shoe to a low heel shoe. The shoe may include three parts: a removable stelo, a removable high heel attachment, and the corresponding attachment systems integrated into the base shoe sole. The removable high heel attachment may be a standard heel of any design, width and height that has a locking system comprising a threaded post located at the heel base. When the stelo and heel attachment are attached, the shoe may be a high heel shoe. When they are removed, the shoe may be a low heel shoe, or flat shoe.

Abstract: A system architecture for linking one or more derived objects to existing data objects in a data structure can be organized in a variety of forms. A method for establishing the architecture may include linking first and second data objects. The first data object may include a first plurality of properties, and the second data object may include a second plurality of properties. At least one of the second plurality of properties may be based on the first plurality of properties. The method may further include receiving, by a computer, a user limitation of a property type that is associated with the at least one of the second plurality of properties. The method may include deriving, based on the user limitation, a new object that includes a third plurality of properties. The third plurality of properties may include a subset of one or more of the first and second pluralities of properties. The new object may be linked to the first and second data objects.

Abstract: An exemplary method includes generating, by a trust computer system, script instructions to carry out a transaction involving one or more digital wallets held in a trust custody account so as to verify control of digital assets held in the one or more digital wallets, the trust computer system being operatively connected to a decentralized digital asset network that uses a decentralized electronic ledger in the form of a blockchain maintained by a plurality of computer systems to track asset ownership and/or transactions in a digital asset system, and generating script instructions includes accessing a statement associated with an event that occurred within a predetermined time frame, and generating, by the trust computer system, based on the script instructions, a transaction that involves a zero net payment from the account along with the statement, and payment of a transaction fee from a separate operating account.

Abstract: A DC-DC converter includes a bridge circuit, a resonant tank circuit coupled to an output of the bridge circuit; a rectifier circuit having an input coupled to the resonant tank circuit and an output, and an output filter coupled to the output of the rectifier circuit. A controller is coupled to the bridge circuit, the resonant tank circuit and the output of the DC-DC converter. The controller is configured to control a switching frequency of the bridge circuit to operate the DC-DC converter as a boost converter and a buck converter. When the DC-DC converter is operating as a buck converter, the controller controls the rectifier circuit to selectively block energy transfer from the rectifier circuit to the converter output based upon an output current of the DC-DC converter being greater than current demand thereof, thereby reducing output current of the DC-DC converter and extending an operating range thereof.

Abstract: A DC-DC converter includes a bridge circuit, a resonant tank circuit coupled to an output of the bridge circuit; a rectifier circuit having an input coupled to the resonant tank circuit and an output, and an output filter coupled to the output of the rectifier circuit. A controller is coupled to the bridge circuit, the resonant tank circuit and the output of the DC-DC converter. The controller is configured to control a switching frequency of the bridge circuit to operate the DC-DC converter as a boost converter and a buck converter. When the DC-DC converter is operating as a buck converter, the controller controls the rectifier circuit to selectively block energy transfer from the rectifier circuit to the converter output based upon an output current of the DC-DC converter being greater than current demand thereof, thereby reducing output current of the DC-DC converter and extending an operating range thereof.

Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.

Abstract: This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

Abstract: A system and method by which energy from ocean waves is converted into hydrogen, and that hydrogen is used to manifest electrical and mechanical energies by an energy consuming device. A portion of the generated electrical power is communicated to water electrolyzers which produce oxygen and hydrogen from water as gases. At least a portion of the generated hydrogen gas is transferred to a transportation ship via a hose-carrying, remotely operated (or otherwise unmanned) vehicle, and subsequently transferred to an energy-consuming module or infrastructur, where a portion of the hydrogen is consumed in order to manifest a generation of electrical energy, a mechanical motion, and/or a chemical reaction.

Abstract: A system and method by which energy from ocean waves is converted into hydrogen, and that hydrogen is used to manifest electrical and mechanical energies by an energy consuming device. A portion of the generated electrical power is communicated to water electrolyzers which produce oxygen and hydrogen from water as gases. At least a portion of the generated hydrogen gas is transferred to a transportation ship via a hose-carrying, remotely operated (or otherwise unmanned) vehicle, and subsequently transferred to an energy-consuming module or infrastructur, where a portion of the hydrogen is consumed in order to manifest a generation of electrical energy, a mechanical motion, and/or a chemical reaction.

Abstract: Servers and method for use in creating a random reward are disclosed. One exemplary method includes receiving a request for a random reward from an organizer, establishing a random reward in response to the request, transmitting a credential associated with the random reward to a player, and crediting gaming activity associated with the credential to the random reward. Access to the random reward is limited to players presenting the credential.

Abstract: A headphone may employ an ear pad mounted to a housing. Affixing a soft sticky or tacky non-adhesive polymer base to the underside of a headphone ear pad allows easy attachment of ear pads to a headphone with the ability to frequently and non-destructively swap pads, without the weight, bulk and fragility of other pad attachment mechanisms.

Abstract: Features are disclosed for managing routing rules stored by a routing device and used to manage network traffic in a network. A computing device can receive multiple routing rules corresponding to multiple routing devices in the network. The computing device can use a formal specification and a snapshot to generate a model of the network. The computing device may use the model in order to statically determine the set of possible paths without causing the transmission of data between a routing device and a destination. the computing device may compare the identified routing rules and the possible paths in order to determine excess routing rules. The computing device may remove the excess routing rules from the routing rules for each routing device such that each routing device routes subsequent network traffic based on the updated routing rules.

Abstract: Embodiments are directed to managing data models. A data source that includes records may be provided. Source fields may be determined based on the records and the source fields may be displayed in a source panel. A data model that includes a source data object may be displayed. Relationships between the source fields may be determined based on values in the records. In response to providing a relationship between the source fields, a data object that includes a key field and one or more data fields that correspond to the relationship may be generated. The data model may be modified to include the data object and to remove the source fields that correspond to the data fields.