Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Techniques and apparatuses for view-selection feedback for a visual experience are described. These techniques and apparatuses enable writers, directors, and other story creators to create or alter visual experiences based on feedback provided by view selections made during visual experiences. This feedback can be analyzed to determine portions of a visual experience that users focused on, wanted to see more of, were not interested in, found difficult to understand, and so forth. With this feedback, visual experiences, such as live-action movies and animated shorts, can be created or improved.

Abstract: The present invention relates to novel compounds of formula (I) (I) that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.

Abstract: A toilet, wherein: the toilet has an aperture (110), which, in use, would be located in an upper part of the toilet; the toilet comprising or adapted to receive a dispensing means arranged beneath the aperture for dispensing a tube (12) of collection bag material in a downward direction; wherein the toilet is adapted such that, in operation, while the tube is moved downward, the toilet creates a divide in the tube by pressing the sides of the tube together.

Abstract: The present invention describes a pigment dispersion and a printing ink and coating employing the pigment dispersion. The pigment dispersion includes a pigment, binder and solvent. The pigment dispersion has a mean particle size less than about 120 nm. The printing ink or coating includes the pigment dispersion in addition to a solvent. The printing ink or coating has a solid binder to pigment ratio greater than about 1.5.

Abstract: A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in the treatment of inflammatory or obstructive airways diseases or mucosal hydration, including, for example cystic fibrosis. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: This document describes techniques and apparatuses for small-screen movie-watching using a viewport. These techniques enable viewers to experience movies and other media programs using a small screen as a viewport to the movie rather than dramatically compressing or cropping the movie to fit the small screen. A viewer may select whatever portion of the movie imagery he or she desires to experience through the small screen at a size sufficient to perceive details of plot elements and an environment in which the plot elements interact. Thus, the viewer may follow plot elements central to the plot while also exploring the environment that provides context for these plot elements.

Abstract: This document describes techniques and apparatuses enabling view-driven consumption of frameless media. These techniques and apparatuses provide frameless media and enable a user to engage with the frameless media by orienting a viewing device within the world created by that frameless media. This orienting by the user drives what the user sees in this world and when the user sees it.

Abstract: Techniques and apparatuses for visual storytelling on a mobile media-consumption device are described. These techniques and apparatuses enable a user to view events central to the story while also viewing context for the story. By so doing, a user may enjoy the story as the story's author intended without sacrificing a user's ability to engage with the story's context.

Abstract: A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in the treatment of inflammatory or obstructive airways diseases or mucosal hydration, including, for example cystic fibrosis. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: An electrical plug safety device (10) comprising a body (16) having apertures for receiving pins (14) of an electrical plug (12). A securing member 32 is provided within the body (16) to engage with a side of at least one of said pins (14) when the pins (14) are received in the apertures such that engagement between the securing member (32) and the side of the pin (14) restricts removal of the plug (12) from the body (16). When sufficient force is applied to the body (16) in a direction away from the plug (12), the securing member (32) is disengaged from the pin (14) and moves such that the securing member (32) will not re-engage with a pin (14) inserted into the body (16).

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.