Abstract: A toilet, wherein: the toilet has an aperture (110), which, in use, would be located in an upper part of the toilet; the toilet comprising or adapted to receive a dispensing means arranged beneath the aperture for dispensing a tube (12) of collection bag material in a downward direction; wherein the toilet is adapted such that, in operation, while the tube is moved downward, the toilet creates a divide in the tube by pressing the sides of the tube together.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: An electrical plug safety device (10) comprising a body (16) having apertures for receiving pins (14) of an electrical plug (12). A securing member 32 is provided within the body (16) to engage with a side of at least one of said pins (14) when the pins (14) are received in the apertures such that engagement between the securing member (32) and the side of the pin (14) restricts removal of the plug (12) from the body (16). When sufficient force is applied to the body (16) in a direction away from the plug (12), the securing member (32) is disengaged from the pin (14) and moves such that the securing member (32) will not re-engage with a pin (14) inserted into the body (16).

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The invention describes novel pharmaceutically acceptable salt forms of camostat, processes for lyophilisation, taste-masked formulations, nebulised formulations and the use of each of the fore-going in the treatment of respiratory diseases, particularly cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Abstract: An apparatus, system, and method for an inline display of related blog postings. The apparatus, system, and method include searching a first blog for material common to the first blog and to a second blog and adding a link to the common material in the second blog. The link includes an interactive indicator in the second blog that displays a posting from the first blog that contains the common material in response to selection of the indicator. The apparatus, system, and method include marking each posting in the first blog that contains the common material and that has been displayed in the second blog as having been read.

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: An audio broadcast creation client applies the concept of style sheets to audio data intended for audio broadcasts. The creation client associates style sheet elements to sections of the audio broadcast. An audio broadcast rendering engine applies the style sheet elements at runtime to alter or enhance sections of the audio broadcast. Different style sheets may be applied to the same raw audio broadcast data to alter the end result. A template is provided for generating audio broadcasts. The user may record the appropriate audio files and refer to these audio files in fields of the audio broadcast template.

Abstract: The present invention concerns a compound of formula Ia wherein: Ra* is hydrogen or C1-C4-alkyl; Rb* is —(C1-C4-alkylene)-Y—C1-C4-haloalkyl or —(C1-C4-alkylene)-Y—C1-C4-hydroxyalkyl; Y represents —CONH— or a five membered heteroaryl group.

Abstract: Compounds of Formula I: in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: Compounds of Formula I: in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Abstract: A blast movement monitor for measuring the movement of material within a body of material as a result of a blasting operation, the monitor including: a housing having an interior chamber defining an inner surface; and an internal communication device that is received immediately within the interior chamber of the housing, the internal communication device including: a body portion; an electric coil wound around the body portion; a circuit board electrically connected to the coil; a battery electrically connected to the circuit board; an end portion associated with one end of the body portion; and a cap associated with an opposing end of the body portion that encapsulates the body portion and sealingly houses the body portion; wherein the internal communication device is biased to facilitate self-righting of the internal communication device to a desired orientation within the interior chamber independent of the orientation of the monitor.

Abstract: A system for information capture for use in an environment is provided. Each node in a knowledge network associated with a first piece of expertise information that communicates with at least one other node associated with the first piece of expertise information is aggregated to form a first expertise network. Each node in the first expertise network associated with a second piece of expertise information that communicates with at least one other node associated with the second piece of expertise information is aggregated to form a second expertise network. Visual representations of the knowledge network, the first expertise network, and the second expertise network are generated. Trends and patterns are determined using the visualization of the knowledge network, the visualization of the first expertise network, and the visualization of the second expertise network.

Abstract: An apparatus for managing outputs of a first application and a second application is provided. Each application is operable to execute on a data processing system and output of the first application is executed on the data processing system. The apparatus comprises a classifier for associating the first application and the second application with classification data, wherein the classification data is stored in a classification data structure; a comparator for comparing the classification data associated with the first application and the second application with the classification data structure to determine a priority; and a generator, responsive to determination of the priority, for generating metadata associated with at least one of: the output of the first application and the output of the second application.

Abstract: A dry colorant composition is disclosed and contains (a) pigment; (b) inert carrier; and (c) rheological additive having the structure: P—(U—Y)s wherein P is the residue of an organic colorant, Y is a polyalkylene oxide or polyalkylene moiety, U is a linking moiety covalently bonding Y to P, and s is an integer from 1 to 3.

Abstract: A light emitting device (100) comprises a light source (114) mounted in a housing (112), a lens (122) through which light from the source (114) is emitted from the housing (112), and a filter (126) arranged between the light source (114) and the lens (122) to filter the emitted light, the filter (126) being of dichroic type and the lens (122) being asymmetric. The light emitting device (100) may comprise a plurality of light sources (114) and/or the filter (126) may be adapted to transmit perpendicularly incident light and to at least partially reflect obliquely incident light.